LncRNA Fendrr inhibits hypoxia/reoxygenation‐induced cardiomyocyte apoptosis by downregulating p53 expression

2020 ◽  
Vol 72 (9) ◽  
pp. 1211-1220
Author(s):  
Xiang Li ◽  
Liangchun Ni ◽  
Weixin Wang ◽  
Liang Zong ◽  
Bi Yao
Keyword(s):  
Cardiomyocyte Apoptosis ◽  
P53 Expression ◽  
Hypoxia Reoxygenation

lncRNA NRON knockdown alleviates hypoxia/reoxygenation (H/R)-induced cardiomyocyte apoptosis by upregulating HIF-1α expression

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xiaofeng Deng ◽  
Yongqing Liu ◽  
Zesheng Xu ◽  
Zichao Wang
Keyword(s):  
Cardiomyocyte Apoptosis ◽  
Hypoxia Reoxygenation

scholarly journals miR-19a protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis via PTEN/PI3K/p-Akt pathway

2017 ◽  
Vol 37 (6) ◽  
Author(s):  
Guochao Sun ◽  
Ying Lu ◽  
Yingxia Li ◽  
Jun Mao ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Ischemic Injury ◽  
Cardiomyocyte Apoptosis ◽  
Luciferase Reporter ◽  
H9c2 Cells ◽  
Rat Cardiomyocytes ◽  
Protein Levels ◽  
Myocardial Ischemic Injury ◽  
Hypoxia Reoxygenation

miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. The present study was to investigate the effect of miR-19a on myocardial ischemic injury and identified the potential molecular mechanisms involved. Using the H/R model of rat cardiomyocytes H9C2 in vitro, we found that miR-19a was in low expression in H9C2 cells after H/R treatment and H/R dramatically decreased cardiomyocyte viability, and increased lactate dehydrogenase (LDH) release and cardiomyocyte apoptosis, which were attenuated by co-transfection with miR-19a mimic. Dual-luciferase reporter assay and Western blotting assay revealed that PTEN was a direct target gene of miR-19a, and miR-19a suppressed the expression of PTEN via binding to its 3′-UTR. We further identified that overexpression of miR-19a inhibited the expression of PTEN at the mRNA and protein levels. Moreover, PTEN was highly expressed in H/R H9C2 cells and the apoptosis induced by H/R was associated with the increase in PTEN expression. Importantly, miR-19a mimic significantly increased p-Akt levels under H/R. In conclusion, our findings indicate that miR-19a could protect against H/R-induced cardiomyocyte apoptosis by inhibiting PTEN /PI3K/p-Akt signaling pathway.

scholarly journals Clematichinenoside (AR) Attenuates Hypoxia/Reoxygenation-Induced H9c2 Cardiomyocyte Apoptosis via a Mitochondria-Mediated Signaling Pathway

Molecules ◽  
2016 ◽  
Vol 21 (6) ◽  
pp. 683 ◽  
Author(s):  
Haiyan Ding ◽  
Rong Han ◽  
Xueshan Chen ◽  
Weirong Fang ◽  
Meng Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cardiomyocyte Apoptosis ◽  
Hypoxia Reoxygenation

Inhibitory Effect of p53 Upregulated Modulator of Apoptosis Targeting siRNA on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis in Rats

Cardiology ◽  
2012 ◽  
Vol 122 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Shuo Tu ◽  
Zhuo-Qi Liu ◽  
Jing-Jing Fu ◽  
Wei-Feng Zhu ◽  
Da-Ya Luo ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Cardiomyocyte Apoptosis ◽  
Hypoxia Reoxygenation

Long non-coding RNA ROR sponges miR-138 to aggravate hypoxia/reoxygenation-induced cardiomyocyte apoptosis via upregulating Mst1

2020 ◽  
Vol 114 ◽  
pp. 104430 ◽  
Author(s):  
Yan-Hui Hu ◽  
Jing Sun ◽  
Jing Zhang ◽  
Fu-Zhou Hua ◽  
Qin Liu ◽  
...  
Keyword(s):  
Cardiomyocyte Apoptosis ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Hypoxia Reoxygenation
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