scholarly journals Evaluation of hydrogen peroxide efficacy against AZD1222 chimpanzee adenovirus strain in the recombinant COVID‐19 vaccine for application in cleaning validation in a pharmaceutical manufacturing industry

2021 ◽  
Author(s):  
Ana Carolina Ferreira Ballestê Ajorio ◽  
Vinícius Pessanha Rhodes ◽  
Anderson Peclat Rodrigues ◽  
Vanessa Alvaro Diniz ◽  
Josiane Machado Vieira Mattoso ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Manufacturing Industry ◽  
Pharmaceutical Manufacturing ◽  
Cleaning Validation

scholarly journals A Review of the Applications of OCT for Analysing Pharmaceutical Film Coatings

2018 ◽  
Vol 8 (12) ◽  
pp. 2700 ◽  
Author(s):  
Hungyen Lin ◽  
Zijian Zhang ◽  
Daniel Markl ◽  
J. Zeitler ◽  
Yaochun Shen
Keyword(s):  
Thin Film ◽  
Optical Coherence Tomography ◽  
Manufacturing Industry ◽  
Dosage Forms ◽  
Pharmaceutical Manufacturing ◽  
Pharmaceutical Dosage Forms ◽  
Film Coatings ◽  
Thin Film Coatings ◽  
Topical Review ◽  
Non Destructive

Optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical manufacturing industry as a fast, contactless and non-destructive modality for quantifying thin film coatings on pharmaceutical dosage forms, which cannot be resolved easily with other techniques. In this topical review, we present an overview of the research that has been performed to date, highlighting key differences between systems and outlining major challenges ahead.

Deterrents to knowledge-sharing in the pharmaceutical industry: a case study

2015 ◽  
Vol 19 (2) ◽  
pp. 296-314 ◽  
Author(s):  
Athar Mahmood Ahmed Qureshi ◽  
Nina Evans
Keyword(s):  
Pharmaceutical Industry ◽  
Knowledge Sharing ◽  
Pharmaceutical Company ◽  
Manufacturing Industry ◽  
Current Knowledge ◽  
Pharmaceutical Manufacturing ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Content Type

Purpose – This study aims to explore deterrents to knowledge-sharing in pharmaceutical manufacturing. Effective knowledge-sharing is fundamental to stimulation of the process of knowledge absorption. The limited proximal communication between the employees in the pharmaceutical industry stifles their knowledge-sharing behaviour significantly. Design/methodology/approach – A cross-sectional case study, consisting of semi-structured interviews with managers and scientists, was conducted in a multinational pharmaceutical company in Australia. Respondents were asked to answer questions regarding their current knowledge-sharing practices and to identify organisational deterrents to knowledge-sharing. The data were condensed into themes according to the thematic analysis method. Findings – The pharmaceutical industry is extensively regulated and its excessive competitiveness is cultivating organisational reticence towards the development of a knowledge-sharing culture. Nine categories of deterrents to intra- (within) and inter-organisational (between organisations) knowledge-sharing have been identified. These categories include high cost of sharing knowledge, information technology limitations, knowledge-hiding, lack of socialisation, lack of trust culture, non-educational mindset, organisational politics, poor leadership and time pressure. Research limitations/implications – The population of this study consists of managers and practitioners working for a pharmaceutical company. Hence, the generalisability of the findings to other health-care settings is unknown. Practical implications – The findings have implications for leaders and managers who should be aware of these professional diversities, instigators as well as the ripple effects of limited knowledge-sharing to guide the organisation towards developing an optimal knowledge-sharing culture. Originality/value – A focussed investigation of knowledge-sharing behaviour within the pharmaceutical industry in Australia, considering the pressure applied to this industry over the past decade. This case study specifically focusses on the diversity of deterrents to knowledge-sharing in the pharmaceutical manufacturing industry.

Determination of Residues of Acetaminophen, Caffeine, and Drotaverine Hydrochloride on Swabs Collected from Pharmaceutical Manufacturing Equipment Using HPLC in Support of Cleaning Validation

2014 ◽  
Vol 97 (5) ◽  
pp. 1439-1445 ◽  
Author(s):  
Mohamed E M Hassouna ◽  
Yousry M Issa ◽  
Ashraf G Zayed
Keyword(s):  
Mobile Phase ◽  
Hplc Method ◽  
Pharmaceutical Manufacturing ◽  
Manufacturing Equipment ◽  
Cleaning Validation ◽  
Accuracy And Precision ◽  
Drotaverine Hydrochloride ◽  
Time Required ◽  
Isocratic Mode

Abstract An HPLC method was developed for the simultaneous determination of residues of acetaminophen (paracetamol, PA), caffeine (CA), and drotaverine HCl (DH) on swabs collected from pharmaceutical manufacturing equipment surfaces. The challenge in cleaning validation is to develop analytical methods that are sensitive enough to detect traces of the active compounds remaining on the surface of pharmaceutical manufacturing equipment after cleaning. Chromatography was performed in the isocratic mode on a Hypersil C18 BDS column using the mobile phase 0.02 M tetrabutylammonium bisulfate–methanol (100 + 45, v/v) at 50°C with UV detection at 210 nm. The method was tested for specificity, linearity, LOD, LOQ, accuracy, and precision for determination of traces of the above-mentioned drugs. The time required for a single analysis was 12 min. The response was linear in the ranges of 6.900–52.100, 1.040–7.800, and 0.694–5.210 μg/mL for PA, CA, and DH, respectively.

scholarly journals How Technological Innovation Affect China’s Pharmaceutical Smart Manufacturing Industrial Upgrading

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Su Wang ◽  
Yuwen Chen
Keyword(s):  
Technological Innovation ◽  
Manufacturing Industry ◽  
New Technologies ◽  
Digital Transformation ◽  
Pharmaceutical Manufacturing ◽  
Smart Manufacturing ◽  
Manufacturing Companies ◽  
Industrial Upgrading ◽  
Depth Analysis ◽  
Innovative Resources

In recent years, a new generation of information technology has provided sufficient technical support for the smart manufacturing industry. In order to promote the upgrading of China’s pharmaceutical smart manufacturing industry, the direction of industrial upgrading and transformation will be discussed from the perspective of technological innovation. According to the input and output data of technological innovation in China’s pharmaceutical manufacturing industry from 2007 to 2019, the DEA method is used to analyze the allocation of innovative resources in China’s pharmaceutical manufacturing industry in recent years. The study found that the efficiency of technological innovation in China’s pharmaceutical manufacturing industry fluctuated greatly from 2007 to 2019, with a low overall level and varying degrees of wasted resources. On this basis, an in-depth analysis of the system architecture of the pharmaceutical smart manufacturing industry under the Industry 4.0 environment was performed. Finally, four paths for the digital transformation of China’s pharmaceutical manufacturing industry are proposed. Chinese pharmaceutical manufacturing companies need to use new technologies to carry out comprehensive intelligent upgrading and digital transformation to improve innovation efficiency.

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