scholarly journals Chromosome arm-specific patterns of polymorphism associated with chromosomal inversions in the major African malaria vector,Anopheles funestus

2017 ◽  
Vol 26 (20) ◽  
pp. 5552-5566 ◽  
Author(s):  
Colince Kamdem ◽  
Caroline Fouet ◽  
Bradley J. White
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus ◽  
Chromosomal Inversions ◽  
Chromosome Arm

scholarly journals Chromosomal Inversions, Natural Selection and Adaptation in the Malaria Vector Anopheles funestus

2010 ◽  
Vol 28 (1) ◽  
pp. 745-758 ◽  
Author(s):  
D. Ayala ◽  
M. C. Fontaine ◽  
A. Cohuet ◽  
D. Fontenille ◽  
R. Vitalis ◽  
...  
Keyword(s):  
Natural Selection ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
Chromosomal Inversions

scholarly journals Chromosome arm specific patterns of polymorphism associated with chromosomal inversions in the major African malaria vector, Anopheles funestus

2016 ◽  
Author(s):  
Colince Kamdem ◽  
Caroline Fouet ◽  
Bradley J. White
Keyword(s):  
Chromosomal Rearrangements ◽  
Anopheles Funestus ◽  
Sequence Divergence ◽  
Sub Saharan Africa ◽  
Chromosomal Inversions ◽  
Genomic Analyses ◽  
Chromosome Arm ◽  
Sub Saharan ◽  
Moisture Conditions ◽  
Two Populations

AbstractChromosomal inversions facilitate local adaptation of beneficial mutations and modulate genetic polymorphism, but the extent of their effects within the genome is still insufficiently understood. The genome of Anopheles funestus, a malaria mosquito endemic to sub-Saharan Africa, contains an impressive number of paracentric polymorphic inversions, which are unevenly distributed among chromosomes and provide an excellent framework for investigating the genomic impacts of chromosomal rearrangements. Here we present results of a fine-scale analysis of genetic variation within the genome of two weakly differentiated populations of Anopheles funestus inhabiting contrasting moisture conditions in Cameroon. Using population genomic analyses, we found that genetic divergence between the two populations is centered on regions of the genome corresponding to three inversions, which are characterized by high values of FST, absolute sequence divergence and fixed differences. Importantly, in contrast to the 2L chromosome arm, which is collinear, nucleotide diversity is significantly reduced along the entire length of three autosome arms bearing multiple overlapping chromosomal rearrangements. These findings support the idea that interactions between reduced recombination and natural selection within inversions contribute to sculpt nucleotide polymorphism across chromosomes in An. funestus.

scholarly journals Towards understanding transfluthrin efficacy in a pyrethroid-resistant strain of the malaria vector Anopheles funestus with special reference to cytochrome P450-mediated detoxification

2021 ◽  
pp. 100041
Author(s):  
Melanie Nolden ◽  
Andreas Brockmann ◽  
Ulrich Ebbinghaus-Kintscher ◽  
Kai-Uwe Brueggen ◽  
Sebastian Horstmann ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Special Reference ◽  
Malaria Vector ◽  
Resistant Strain ◽  
Anopheles Funestus

scholarly journals Thermal limits of wild and laboratory strains of two African malaria vector species, Anopheles arabiensis and Anopheles funestus

2012 ◽  
Vol 11 (1) ◽  
Author(s):  
Candice L Lyons ◽  
Maureen Coetzee ◽  
John S Terblanche ◽  
Steven L Chown
Keyword(s):  
Malaria Vector ◽  
Anopheles Arabiensis ◽  
Anopheles Funestus ◽  
Vector Species ◽  
Thermal Limits

scholarly journals Evidence of a multiple insecticide resistance in the malaria vector Anopheles funestus in South West Nigeria

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Rousseau J. Djouaka ◽  
Seun M. Atoyebi ◽  
Genevieve M. Tchigossou ◽  
Jacob M. Riveron ◽  
Helen Irving ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
South West

scholarly journals A chromosome-scale assembly of the major African malaria vector Anopheles funestus

GigaScience ◽  
2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Jay Ghurye ◽  
Sergey Koren ◽  
Scott T Small ◽  
Seth Redmond ◽  
Paul Howell ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus

scholarly journals Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213949 ◽  
Author(s):  
Ange Tchakounte ◽  
Magellan Tchouakui ◽  
Chiang Mu-Chun ◽  
Williams Tchapga ◽  
Edmond Kopia ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus

scholarly journals A marker of glutathione S-transferase-mediated resistance to insecticides is associated with higher Plasmodium infection in the African malaria vector Anopheles funestus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Magellan Tchouakui ◽  
Mu-Chun Chiang ◽  
Cyrille Ndo ◽  
Carine K. Kuicheu ◽  
Nathalie Amvongo-Adjia ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus ◽  
Plasmodium Infection ◽  
Glutathione S Transferase

Isolation of polymorphic microsatellite loci from the malaria vector Anopheles funestus

2000 ◽  
Vol 9 (4) ◽  
pp. 490-492 ◽  
Author(s):  
S. P. Sinkins ◽  
B. J. Hackett ◽  
C. Costantini ◽  
J. Vulule ◽  
Y-Y. Ling ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Microsatellite Loci ◽  
Anopheles Funestus ◽  
Polymorphic Microsatellite

scholarly journals Chromosome and Genome Divergence between the Cryptic Eurasian Malaria Vector-Species Anopheles messeae and Anopheles daciae

Genes ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 165 ◽  
Author(s):  
Anastasia N. Naumenko ◽  
Dmitriy A. Karagodin ◽  
Andrey A. Yurchenko ◽  
Anton V. Moskaev ◽  
Olga I. Martin ◽  
...  
Keyword(s):  
X Chromosome ◽  
Malaria Vector ◽  
Its2 Region ◽  
Nucleotide Substitutions ◽  
Closely Related Species ◽  
Chromosomal Inversions ◽  
Chromosome Inversions ◽  
Genome Wide ◽  
Genome Divergence ◽  
Incomplete Reproductive Isolation

Chromosomal inversions are important drivers of genome evolution. The Eurasian malaria vector Anopheles messeae has five polymorphic inversions. A cryptic species, An. daciae, has been discriminated from An. messeae based on five fixed nucleotide substitutions in the internal transcribed spacer 2 (ITS2) of ribosomal DNA. However, the inversion polymorphism in An. daciae and the genome divergence between these species remain unexplored. In this study, we sequenced the ITS2 region and analyzed the inversion frequencies of 289 Anopheles larvae specimens collected from three locations in the Moscow region. Five individual genomes for each of the two species were sequenced. We determined that An. messeae and An. daciae differ from each other by the frequency of polymorphic inversions. Inversion X1 was fixed in An. messeae but polymorphic in An. daciae populations. The genome sequence comparison demonstrated genome-wide divergence between the species, especially pronounced on the inversion-rich X chromosome (mean Fst = 0.331). The frequency of polymorphic autosomal inversions was higher in An. messeae than in An. daciae. We conclude that the X chromosome inversions play an important role in the genomic differentiation between the species. Our study determined that An. messeae and An. daciae are closely related species with incomplete reproductive isolation.

Sign in / Sign up

Export Citation Format

Share Document