Characteristics and risk factors for mortality of invasive non‐
            Aspergillus
            mould infections in patients with haematologic diseases: A single‐centre 7‐year cohort study

Abstract Background Chemoradiation with capecitabine followed by surgery is standard care for locally advanced rectal cancer (LARC). Severe diarrhea is considered a dose-limiting toxicity of adding capecitabine to radiation therapy. The aim of this study was to describe the risk factors and the impact of body composition on severe diarrhea in patients with LARC during preoperative chemoradiation with capecitabine. Methods A single centre retrospective cohort study was conducted in a tertiary referral centre. All patients treated with preoperative chemoradiation with capecitabine for LARC from 2009 to 2015 were included. Patients with locally recurrent rectal cancer who received chemoradiation for the first time were included as well. Logistic regression analyses were performed to identify risk factors for severe diarrhea. Results A total of 746 patients were included. Median age was 64 years (interquartile range 57–71) and 477 patients (64%) were male. All patients received a radiation dosage of 25 × 2 Gy during a period of five weeks with either concomitant capecitabine administered on radiation days or continuously during radiotherapy. In this cohort 70 patients (9%) developed severe diarrhea. In multivariable logistic regression analyses female sex (OR: 4.42, 95% CI 2.54–7.91) and age ≥ 65 (OR: 3.25, 95% CI 1.85–5.87) were the only risk factors for severe diarrhea. Conclusions Female patients and patients aged sixty-five or older had an increased risk of developing severe diarrhea during preoperative chemoradiation therapy with capecitabine. No relation was found between body composition and severe diarrhea.

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Risk factors for treatment failure in patients receiving β-lactam/β-lactamase inhibitor combinations for Enterobacteriaceae bloodstream infection: A retrospective, single-centre, cohort study

International Journal of Antimicrobial Agents ◽

10.1016/j.ijantimicag.2019.01.005 ◽

2019 ◽

Vol 53 (5) ◽

pp. 574-581 ◽

Cited By ~ 1

Author(s):

Maddalena Giannella ◽

Renato Pascale ◽

Giuseppe Ferraro ◽

Alice Toschi ◽

Livia Pancaldi ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Treatment Failure ◽

Bloodstream Infection ◽

Single Centre ◽

Lactamase Inhibitor

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Complications rate of and risk factors for the unplanned reoperation of degenerative lumbar spondylolisthesis in elderly patients: a retrospective single-Centre cohort study of 33 patients

BMC Geriatrics ◽

10.1186/s12877-020-01717-2 ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Weiyang Zhong ◽

Xinjie Liang ◽

Xiaoji Luo ◽

Tianji Huang ◽

Zhengxue Quan

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Elderly Patients ◽

Single Centre ◽

Degenerative Lumbar Spondylolisthesis ◽

Lumbar Spondylolisthesis ◽

Complications Rate

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Prevalence and risk factors of pre-diabetes after renal transplantation: a single-centre cohort study in 200 consecutive patients

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfs020 ◽

2012 ◽

Vol 27 (8) ◽

pp. 3330-3337 ◽

Cited By ~ 8

Author(s):

F.-P. Tillmann ◽

I. Quack ◽

A. Schenk ◽

B. Grabensee ◽

L. C. Rump ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Renal Transplantation ◽

Single Centre

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Risk factors associated with surgical site infections after thoracic or lumbar surgery: a 6-year single centre prospective cohort study

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02418-1 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Vera Spatenkova ◽

Ondrej Bradac ◽

Zdenek Jindrisek ◽

Jan Hradil ◽

Daniela Fackova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Cohort Study ◽

Logistic Regression Analysis ◽

Multivariate Logistic Regression Analysis ◽

Wound Complications ◽

Multivariate Logistic Regression ◽

Single Centre

Abstract Background Surgical site infection (SSI) is a risk in every operation. Infections negatively impact patient morbidity and mortality and increase financial demands. The aim of this study was to analyse SSI and its risk factors in patients after thoracic or lumbar spine surgery. Methods A six-year single-centre prospective observational cohort study monitored the incidence of SSI in 274 patients who received planned thoracic or lumbar spinal surgery for degenerative disease, trauma, or tumour. They were monitored for up to 30 days postoperatively and again after 1 year. All patients received short antibiotic prophylaxis and stayed in the eight-bed neurointensive care unit (NICU) during the immediate postoperative period. Risk factors for SSI were sought using multivariate logistic regression analysis. Results We recorded 22 incidences of SSI (8.03%; superficial 5.84%, deep 1.82%, and organ 0.36%). Comparing patients with and without SSI, there were no differences in age (p=0.374), gender (p=0.545), body mass index (p=0.878), spine diagnosis (p=0.745), number of vertebrae (p=0.786), spine localization (p=0.808), implant use (p=0.428), American Society of Anesthesiologists (ASA) Score (p=0.752), urine catheterization (p=0.423), drainage (p=0.498), corticosteroid use (p=0.409), transfusion (p=0.262), ulcer prophylaxis (p=0.409) and diabetes mellitus (p=0.811). The SSI group had longer NICU stays (p=0.043) and more non-infectious hospital wound complications (p<0.001). SSI risk factors according to our multivariate logistic regression analysis were hospital wound complications (OR 20.40, 95% CI 7.32–56.85, p<0.001) and warm season (OR 2.92, 95% CI 1.03–8.27, p=0.044). Conclusions Contrary to the prevailing literature, our study did not identify corticosteroids, diabetes mellitus, or transfusions as risk factors for the development of SSI. Only wound complications and warm seasons were significantly associated with SSI development according to our multivariate regression analysis.

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