scholarly journals The impact of ABCDE bundle implementation on patient outcomes: A nationwide cohort study

2022 ◽  
Author(s):  
María Jesús Frade‐Mera ◽  
Susana Arias‐Rivera ◽  
Ignacio Zaragoza‐García ◽  
Joan Daniel Martí ◽  
Elisabet Gallart ◽  
...  
Keyword(s):  
Cohort Study ◽  
Patient Outcomes ◽  
Abcde Bundle ◽  
The Impact

scholarly journals Comparing the impact of Hydroxychloroquine based regimens and standard treatment on COVID-19 patient outcomes: A retrospective cohort study

2020 ◽  
Vol 28 (12) ◽  
pp. 1877-1882 ◽  
Author(s):  
Saja H. Almazrou ◽  
Ziyad S. Almalki ◽  
Abdullah S. Alanazi ◽  
Abdulhadi M. Alqahtani ◽  
Saleh M. Alghamd
Keyword(s):  
Cohort Study ◽  
Patient Outcomes ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Standard Treatment ◽  
The Impact

SP7.1.7 The impact of surgical subspecialisation on patient outcomes in those admitted with gallstone disease in the North of England: a retrospective cohort study

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Julia McGovern ◽  
John Young ◽  
Leo Brown ◽  
Ross McLean
Keyword(s):  
Cohort Study ◽  
Length Of Stay ◽  
Patient Outcomes ◽  
Conservative Management ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Gallstone Disease ◽  
Mortality Data ◽  
The North ◽  
The Impact

Abstract The management of gallstone disease has evolved over time and includes laparoscopic and open cholecystectomy, interventional radiology, endoscopic intervention and conservative management. Subspecialisation within general surgery is commonplace, allowing development of specialist skillsets. The aim of this study is to assess the impact of consultant subspecialisation on patient outcomes in those admitted with gallstone disease. A retrospective cohort study - data was collected on patients admitted with gallstone disease in the North of England between 2002 and 2016. Subspecialisation was categorised as Upper GI or other general subspecialties. The primary outcome of interest was overall 30-day mortality; secondary outcomes included surgical approach and length of stay. A total of 62,286 patients were admitted with gallstone disease. Overall 30-day mortality was 2.1%. The UGI specialists had a higher operative rate - 21.5% vs 10.7% (<0.001) than their colleagues including performing more laparoscopic cholecystectomies– 15.6% vs 6.4% (<0.001), and on-table cholangiogram (OTC) – 3.5% vs 1.5% (p < 0.001). 22,071 patients were diagnosed with acute cholecystitis. Non-UGI Consultants preferred conservative management (76.5% vs 59.0% - p < 0.001) which did not significantly affect 30-day mortality. Data was analysed using IBM SPSS Statistics. Categorical data were compared with chi-square test, and continuous data with t-test or ANOVA. Statistical significance was defined as a p value of ≤ 0.05. UGI consultants performed significantly more “hot gallbladders” than their non-UGI counterparts. UGI consultants choose to operate laparoscopically and perform significantly more OTCs, likely reducing need for pre-operative MRCP but not significantly reducing overall 30-day mortality or length of stay.

scholarly journals Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e052842
Author(s):  
Jennifer Taher ◽  
Chloe Mighton ◽  
Sunakshi Chowdhary ◽  
Selina Casalino ◽  
Erika Frangione ◽  
...  
Keyword(s):  
Immune Response ◽  
Cohort Study ◽  
Antibody Response ◽  
Patient Outcomes ◽  
Patient Reported Outcomes ◽  
Sequence Information ◽  
Management Protocol ◽  
Patient Reported ◽  
The Impact ◽  
Viral Lineage

IntroductionThere is considerable variability in symptoms and severity of COVID-19 among patients infected by the SARS-CoV-2 virus. Linking host and virus genome sequence information to antibody response and biological information may identify patient or viral characteristics associated with poor and favourable outcomes. This study aims to (1) identify characteristics of the antibody response that result in maintained immune response and better outcomes, (2) determine the impact of genetic differences on infection severity and immune response, (3) determine the impact of viral lineage on antibody response and patient outcomes and (4) evaluate patient-reported outcomes of receiving host genome, antibody and viral lineage results.Methods and analysisA prospective, observational cohort study is being conducted among adult patients with COVID-19 in the Greater Toronto Area. Blood samples are collected at baseline (during infection) and 1, 6 and 12 months after diagnosis. Serial antibody titres, isotype, antigen target and viral neutralisation will be assessed. Clinical data will be collected from chart reviews and patient surveys. Host genomes and T-cell and B-cell receptors will be sequenced. Viral genomes will be sequenced to identify viral lineage. Regression models will be used to test associations between antibody response, physiological response, genetic markers and patient outcomes. Pathogenic genomic variants related to disease severity, or negative outcomes will be identified and genome wide association will be conducted. Immune repertoire diversity during infection will be correlated with severity of COVID-19 symptoms and human leucocyte antigen-type associated with SARS-CoV-2 infection. Participants can learn their genome sequencing, antibody and viral sequencing results; patient-reported outcomes of receiving this information will be assessed through surveys and qualitative interviews.Ethics and disseminationThis study was approved by Clinical Trials Ontario Streamlined Ethics Review System (CTO Project ID: 3302) and the research ethics boards at participating hospitals. Study findings will be disseminated through peer-reviewed publications, conference presentations and end-users.

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