Global burden of oral diseases: emerging concepts, management and interplay with systemic health

The human oral cavity harbors approximately 1,000 microbial species, and dysbiosis of the microflora and imbalanced microbiota-host interactions drive many oral diseases, such as dental caries and periodontal disease. Oral microbiota homeostasis is critical for systemic health. Over the last two decades, bacterial protein phosphorylation systems have been extensively studied, providing mounting evidence of the pivotal role of tyrosine and serine/threonine phosphorylation in oral bacterial dysbiosis and bacteria-host interactions. Ongoing investigations aim to discover novel kinases and phosphatases and to understand the mechanism by which these phosphorylation events regulate the pathogenicity of oral bacteria. Here, we summarize the structures of bacterial tyrosine and serine/threonine kinases and phosphatases and discuss the roles of tyrosine and serine/threonine phosphorylation systems in Porphyromonas gingivalis and Streptococcus mutans, emphasizing their involvement in bacterial metabolism and virulence, community development, and bacteria-host interactions.

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Prevention of tooth loss and dental pain for reducing the global burden of oral diseases

International Dental Journal ◽

10.1111/idj.12328 ◽

2017 ◽

Vol 67 ◽

pp. 19-25 ◽

Cited By ~ 15

Author(s):

Susan Hyde ◽

Veronique Dupuis ◽

Boipelo P. Mariri ◽

Sophie Dartevelle

Keyword(s):

Tooth Loss ◽

Dental Pain ◽

Global Burden ◽

Oral Diseases

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The role of the oral microbiota in chronic non-communicable disease and its relevance to the Indigenous health gap in Australia

BMC Oral Health ◽

10.1186/s12903-020-01308-y ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Matilda Handsley-Davis ◽

Lisa Jamieson ◽

Kostas Kapellas ◽

Joanne Hedges ◽

Laura S. Weyrich

Keyword(s):

Oral Health ◽

Indigenous Health ◽

Communicable Disease ◽

Indigenous Communities ◽

Indigenous Australians ◽

Oral Microbiota ◽

Oral Diseases ◽

Emotional Wellbeing ◽

Health Gap ◽

Systemic Health

Abstract Background Aboriginal Australians and Torres Strait Islanders (hereafter respectfully referred to as Indigenous Australians) experience disproportionately poor health and low life expectancy compared to non-Indigenous Australians. Poor oral health is a critical, but understudied, contributor to this health gap. A considerable body of evidence links poor oral health to increased risks of other chronic non-communicable conditions, such as diabetes, cardiovascular disease, chronic kidney disease, and poor emotional wellbeing. Main The oral microbiota is indisputably associated with several oral diseases that disproportionately affect Indigenous Australians. Furthermore, a growing literature suggests direct and indirect links between the oral microbiota and systemic chronic non-communicable diseases that underpin much of the Indigenous health gap in Australia. Recent research indicates that oral microbial communities are shaped by a combination of cultural and lifestyle factors and are inherited from caregivers to children. Systematic differences in oral microbiota diversity and composition have been identified between Indigenous and non-Indigenous individuals in Australia and elsewhere, suggesting that microbiota-related diseases may be distinct in Indigenous Australians. Conclusion Oral microbiota research involving Indigenous Australians is a promising new area that could benefit Indigenous communities in numerous ways. These potential benefits include: (1) ensuring equity and access for Indigenous Australians in microbiota-related therapies; (2) opportunities for knowledge-sharing and collaborative research between scientists and Indigenous communities; and (3) using knowledge about the oral microbiota and chronic disease to help close the gaps in Indigenous oral and systemic health.

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The Neglected Global Burden of Chronic Oral Diseases

Journal of Dental Research ◽

10.1177/154405910608500501 ◽

2006 ◽

Vol 85 (5) ◽

pp. 390-391 ◽

Cited By ~ 15

Author(s):

M.D. Mignogna ◽

S. Fedele

Keyword(s):

Global Burden ◽

Oral Diseases

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The Effects of Menopause on Periodontal Tissue

International Dental Research ◽

10.5577/intdentres.2011.vol1.no3.2 ◽

2011 ◽

Vol 1 (3) ◽

pp. 81

Author(s):

Tuba Talo Yıldırım ◽

Filiz Acun Kaya

Keyword(s):

Older Women ◽

Native Speakers ◽

Epidemiologic Studies ◽

Risk Indicators ◽

Periodontal Tissue ◽

Oral Diseases ◽

Systemic Factors ◽

Native Speakers Of English ◽

Systemic Health ◽

Periodontal Attachment Loss

Periodontitis and gingivitis, a prevalent oral diseases, have been connected to several systemic health changes. The aim of this investigation was to review the effects of menopause on periodontal tissue. Epidemiologic studies have identified a number of risk factors and risk indicators for periodontal attachment loss, including demographic, socioeconomic, behavioral, genetic, and systemic factors. Menopause has also been associated with destructive periodontal disease in older women. The homeostasis of the periodontium involves complex multifactorial relationships. Oestrogen and progesterone are responsible for physiological changes in women at specific phases of their life. Menopause is associated with significant adverse changes in the orofacial complex. How to cite this article: Talo Yıldırım T, Acun Kaya F. The Effects of Menopause on Periodontal Tissue. Int Dent Res 2011;3:81-86. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Evaluation of effect of auditory - aid in improving oral hygiene among visually impaired individuals - Original Study

Clinical Dentistry ◽

10.33882/clinicaldent.13.25201 ◽

2019 ◽

Author(s):

Nagarjuna Tadiboina ◽

Yamuna Marella ◽

Pasupuleti R.N.L. Kiranmayi ◽

Deepika Vasudevan ◽

Gudipati Kameswari

Keyword(s):

Visual Impairment ◽

Oral Hygiene ◽

Visually Impaired ◽

Oral Diseases ◽

Normal Children ◽

Care Givers ◽

Normal Individuals ◽

Challenging Situation ◽

Systemic Health ◽

Oral Hygiene Instructions

Background: Oral health is an integral part of systemic health, which affects the quality of life of an individual. Physically disadvantaged individuals also start their life as normal children but, due to lack of awareness, poor motor skills, negligence of parents and care givers put them at high risk for oral diseases. So, the aim of the present study is toevaluate the effect of auditory aid in improving the oral hygiene among visually impaired children. Materials and Methods: Fifty one (51) Visually impaired individuals of age 8-25 years were included from Kala Bharathi residential school for the blind, Guntur. Oral hygiene index-simplified (OHI-S), gingival index (GI)were recorded at baselineand oral hygiene instructions were given by using Auditory-aid for 3 months. The OHI-S and GI were recorded again after 3 months to evaluate the effect of Auditory –aid. Results: At baseline, oral hygiene of the individuals was moderate to poor and mean OHI-S, GIat baseline were 2.45 and 1.75 respectively. There was improvement in the OHI-S and GI which were found to be 1.17 and 0.95 respectively after 3 months of intervention. Conclusion: Visual impairment is the most challenging situation to the individuals as the prevalence of systemic and oral diseases are more in these individuals when compared to normal individuals. However, if educated and motivated properly with the help of auditory aid these can be made to maintain good oral hygiene. Key Words: Auditory aid, Visual impairment, Oral hygiene

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Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

Disease Markers ◽

10.1155/2018/6141845 ◽

2018 ◽

Vol 2018 ◽

pp. 1-22 ◽

Cited By ~ 13

Author(s):

Alejandro I. Lorenzo-Pouso ◽

Mario Pérez-Sayáns ◽

Susana B. Bravo ◽

Pía López-Jornet ◽

María García-Vence ◽

...

Keyword(s):

Dental Caries ◽

Molecular Biology ◽

Periodontal Disease ◽

Global Burden ◽

Oral Diseases ◽

Biological Matrix ◽

Severe Periodontal Disease ◽

Novel Biomarkers ◽

Proteins And Peptides ◽

Untreated Dental Caries

The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.

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