Protein Tyrosine and Serine/Threonine Phosphorylation in Oral Bacterial Dysbiosis and Bacteria-Host Interaction

The human oral cavity harbors approximately 1,000 microbial species, and dysbiosis of the microflora and imbalanced microbiota-host interactions drive many oral diseases, such as dental caries and periodontal disease. Oral microbiota homeostasis is critical for systemic health. Over the last two decades, bacterial protein phosphorylation systems have been extensively studied, providing mounting evidence of the pivotal role of tyrosine and serine/threonine phosphorylation in oral bacterial dysbiosis and bacteria-host interactions. Ongoing investigations aim to discover novel kinases and phosphatases and to understand the mechanism by which these phosphorylation events regulate the pathogenicity of oral bacteria. Here, we summarize the structures of bacterial tyrosine and serine/threonine kinases and phosphatases and discuss the roles of tyrosine and serine/threonine phosphorylation systems in Porphyromonas gingivalis and Streptococcus mutans, emphasizing their involvement in bacterial metabolism and virulence, community development, and bacteria-host interactions.

PENDAMPINGAN PENERAPAN DIGITAL MARKETING SEBAGAI STRATEGI MARKETING PADA UMKM BAKPAO IJO LUMER

The development of technology today has been increasingly advanced and developed, especially social media that greatly impact and affect people's lives. The development of technology also has an impact on marketing, especially in the process of buying and selling, Digital Marketing is one of the marketing strategies that can reach the wider community from the top to the bottom. Research in this training uses the ABCD method or this training using the ABCD approach that is Asset Based Community Development, which prioritizes the utilization of assets and potential that exist around and owned by the community. Marketing planning in this study aims to develop MSMEs Bakpao Ijo Lumer in Milangasri District Panekan which due to pandemic vovid-19 began to decrease sales, the problems faced by bakpao ijo sellers one of them is in marketing or marketing, With this research bakpao ijo sellers can better know the benefits of technology, especially digital marketing to advertise or sell their bakpao ijo lumer food products, so that with this digital marketing sales turnover and public interest to buy bakpao ijo lumer increases, besides that sellers also get a lot of useful knowledge about digital marketing technology to be able to compete with the market and compete with other bakpao ijo products or other food products that are similar or different. Abstrak Perkembangan teknologi saat ini sudah semakin maju dan berkembang, terutama media sosial yang sangat berdampak dan mempengaruhi kehidupan masyarakat. Perkembangan teknologi juga berdampak pada pemasaran terutama dalam proses jual beli, Digital Marketing merupakan salah satu strategi pemasaran yang dapat menjangkau masyarakat luas mulai dari kalangan atas sampai bawah. Penelitian dalam pelatihan ini menggunakan metode ABCD atau Pelatihan ini menggunakan pendekatan ABCD yaitu Asset Based Community Development, yang mengutamakan pemanfaatan aset dan potensi yang ada di sekitar dan dimiliki oleh komunitas masyarakat. Perencanaan marketing dalam penelitian ini bertujuan untuk mengembangkan UMKM Bakpao Ijo Lumer didesa Milangasri Kecamatan Panekan yang akibat pandemic vovid-19 mulai menurun penjualannya, permasalahan yang dihadapi penjual bakpao ijo salah satunya adalah dalam pemasaran atau marketing, dengan penelitian ini penjual bakpao ijo bisa lebih mengetahui manfaat dari teknologi terutama digital marketing untuk mengiklankan atau menjual produk makanan bakpao ijo lumer miliknya, sehingga dengan digital marketing ini omset penjualan dan minat masyarakat untuk membeli bakpao ijo lumer meningkat, selain itu penjual juga mendapat banyak sekali ilmu yang bermanfaat mengenai teknologi digital marketing untuk bisa bersaing dengan pasar dan bersaing dengan produk bakpao ijo lain ataupun produk makanan lain yang serupa maupun berbeda.

Community Work Approach in Addressing Social Problems: Three Community Case Studies from Sri Lanka

Human development is at the center of social work to intervene in diverse problems affecting humanity. Community work is a direct method of community development that attempts to serve many people at a macro level. A community case study documents a local experience about delivering services to meet an identified need. This paper aims to illustrate three examples of community case studies that were developed while working with three diverse communities in Sri Lanka. The first community case study describes efforts to efforts to promote social harmony through child engagement in a rural community with ethnoreligious diversity in the Polonnaruwa District. The second community case study documents prioritizing several problems faced by an urban, underserved community located close to the Kolonnawa Garbage dump in the Colombo District. The third case study is on women's engagement in community development and harmony in a peri-urban community in the Gampaha District. The paper provides evidence for the effectiveness of community work in addressing diverse social issues in communities.

Pemberdayaan Masyarakat Berbasis Komunitas Zakat Pada Masa Pandemi Di Desa Kahayya, Kabupaten Bulukumba

Zakat as one of the institutions in Islam, has a spiritual dimension and covers many aspects of community empowerment that include various aspects such as economic, social, health, education and religion, especially in the event of a pandemic. One of the community empowerment programs by zakat institutions is Zakat Community Development. One of the community empowerments programs by zakat institutions in this research to find out and analyze the concept of empowerment in the form of Zakat Community Development during the pandemic in Kahayya Village, Bulukumba Regency. The method in this study is qualitatively descriptive by finding detailed information related to the Zakat Community Development program in Kahayya Village, Bulukumba Regency. The results of this study show that several programs have been implemented covering various aspects such as socioeconomic, health, education and religion. In the field of health, disinfectant narrowing, vaccination programs, provision of handwashing, distribution of masks and hand sanitizers to socialization related to the prevention of the spread of the covid-19 virus to the community. Similarly, in the world of education, through ZCD is done the reactivation of reading parks and the development of ICT-based libraries. Socialization in pondok tahfidz as a preventive measure of transmission and healthy life is part of religious empowerment so that students can still learn religion. Especially in the economic aspects formed by several SME communities, namely farmers groups that develop AGROWISATA and horticulture, Kahayya coffee SMEs and honey mustika Kahayya SME groups.Zakat sebagai salah satu pranata dalam Islam, memiliki dimensi spiritual serta mencakup banyak aspek pemberdayaan masyarakat yang meliputi berbagai aspek seperti ekonomi, sosial, kesehatan, pendidikan dan agama, khususnya pada saat terjadi pandemi. Salah satu program pemberdayaan masyarakat oleh lembaga zakat adalah Zakat Community Development. Tujuan penelitian ini untuk mengetahui serta menganalisis konsep pemberdayaan berupa Zakat Community Development pada masa pandemi di Desa Kahayya, Kabupaten Bulukumba. Metode pada penelitian ini adalah kualitatif deskriptif dengan menemukan informasi secara detail terkait program Zakat Community Development di Desa Kahayya, Kabupaten Bulukumba. Hasil penelitian ini menunjukkan bahwa telah dilaksanakan beberapa program yang meliputi berbagai aspek seperti sosial ekonomi, kesehatan, pendidikan maupun keagamaan. Pada bidang kesehatan dilakukan penyemprotan desinfektan, program vaksinasi, penyediaan tempat cuci tangan, pembagian masker dan hand sanitizer hingga sosialisasi terkait pencegahan penyebaran virus covid-19 kepada masyarakat. Demikian pula pada dunia pendidikan, melalui ZCD dilakukan pengaktifan kembali taman baca serta pengembangan perpustakaan berbasis TIK. Sosialisasi di Pondok Tahfidz sebagai langkah pencegahan penularan dan hidup sehat merupakan bagian dari pemberdayaan keagamaan agar santri tetap dapat belajar agama. Terkhusus pada aspek ekonomi yang terbentuk beberapa komunitas UKM yaitu kelompok tani yang mengembangkan AGROWISATA dan holtikultura, UKM Kopi Kahayya serta kelompok UKM Madu Mustika Kahayya.

Masyarakat dan Problematika Administrasi Wakaf (Upaya Pemberdayaan Produktivitas Aset Wakaf di Desa Sooko, Kabupaten Ponorogo)

Problems related to the misused of waqf assets have been taking their long way since previous decades to this era, as what has happened in Sooko Village, Ponorogo. Of the 31 mosques and prayer rooms that do not yet have a certificate, 11 areas have AIW while the rest of those have not recorded to have a waqf pledge. In addition, the discovery of Nadzir data, which recorded almost all of them have died and the waqf data entered in the Ministry of Religion's web (siwak) only lists the use of objects and addresses globally, which becomes a problem in the management of waqf assets. The method used in this research is Asset Based Community Development (ABCD). The results showed that the majority of waqf conditions in Sooko Village, Ponorogo, were not yet certified, Nadzir's Human Resources also still did not meet the expected standards. Stakeholder efforts in solving waqf problems in Sooko village, Ponorogo, are by organizing nadzir professionalism training in managing waqf assets and mass waqf pledges in Sooko sub-district, Ponorogo.Permasalahan yang berkaitan dengan aset wakaf yang disalahgunakan bukanlah merupakan hal baru, begitu pula yang terjadi di desa Sooko Kabupaten Ponorogo. Dari 31 masjid dan mushola belum memiliki sertifikat (11 bidang sudah AIW selebihnya belum melakukan ikrar wakaf). Selain itu, ditemukannya data Nadzir yang tercatat hampir keseluruhan sudah meninggal dunia serta data wakaf yang diinput dalam siwak web kementerian agama hanya mencantumkan kegunaan objek dan alamat secara global menjadi masalah dalam pengelolaan aset wakaf. Metode yang digunakan dalam penelitian ini adalah Asset Bassed Community Development (ABCD). Hasil penelitian menunjukkan bahwa kondisi wakaf di desa Sooko Kabupaten Ponorogo mayoritas belum tersertifikasi, Sumber Daya Manusia Nadzir juga masih belum memenuhi standar yang diharapkan. Adapun upaya Stakeholder dalam penyelesaian problematika wakaf di desa Sooko Kabupaten Ponorogo ialah dengan menyelenggarakan pelatihan profesionalisme nadzir dalam mengelola asset wakaf serta ikrar wakaf massal se kecamatan Sooko Kabupaten Ponorogo.

The Evolution of Community Development Banks Influenced by E-Payment and Its Social Impact on Brazil

Microcredit involves offering credit in small amounts and at low interest rates to economically disadvantaged populations and those who cannot offer guarantees. The offer of microcredit for solidarity purposes is not aimed at increasing an organization's profits but rather toward local economic development and as an initiative to eradicate poverty. The first community development bank was founded in Brazil in 1998. Such banks offer financial, solidary-based, networked services of an associative nature and are aimed at reorganizing local economies through job and income generation and establishment of a solidarity economy. This chapter presents the following problem question: How has the mobile payment or electronic payment technology impacted the performance of Brazilian solidary digital banks? It also presents guidelines for replicating this model in developing countries.