scholarly journals Reconstruction of a Distal Foot Skin Defect Using an Intermediate Dorsal Neurocutaneous Flap

2020 ◽  
Vol 12 (2) ◽  
pp. 442-449
Author(s):  
Siyi Liu ◽  
Jinhai Tan ◽  
Shengxiang Tao ◽  
Yong Duan ◽  
Xiang Hu ◽  
...  
Keyword(s):  
Skin Defect ◽  
Neurocutaneous Flap

Treatment of Delayed Union and Septic Osteomyelitis of Metacarpus III/IV in a Calf Using Gentamicin-impregnated Collagen Sponges and Minimal External Coaptation

1998 ◽  
Vol 11 (01) ◽  
pp. 19-22 ◽  
Author(s):  
A. Steiner ◽  
Gaby Hirsbrunner
Keyword(s):  
Standard Treatment ◽  
Delayed Union ◽  
Surgical Debridement ◽  
Rigid Fixation ◽  
Skin Defect ◽  
Long Time ◽  
Metaphyseal Fracture ◽  
External Stabilization ◽  
Long Acting ◽  
Local Antibiotic

SummaryA newborn calf was admitted for evaluation of a primarily closed comminuted metaphyseal fracture of metacarpus III/IV. Closed reduction and application of transfixation pins and a fibreglass cast were performed. Ten days after pin removal, radiographs revealed that the initially healed fracture had collapsed, and osteomyelitis was diagnosed. Bacteriological culture from the deep draining tract yielded Actinomyces pyogenes and Staphylococcus aureus. Standard treatment of delayed union or nonunion caused by septic osteomyelitis consists of surgical debridement, rigid fixation, and long-time administration of antibiotics. In this case, we used surgical debridement, administration of a new long-acting local antibiotic (gentamicin- impregnated collagen sponges), and minimal external stabilization. At day 27 after initiation of this treatment, the skin defect had healed, and the fracture was stable on manual palpation.Standard treatment of delayed union or nonunion caused by septic osteomyelitis consists of surgical debridement, rigid fixation and prolonged administration of antibiotics. In the case described, we used surgical debridement, administration of a long-acting local antibiotic (gentamicin-impregnated collagen sponges), and minimal external stabilization. The promising outcome of this case and the good results in human surgery warrant further investigation in the use of gentamicin-impregnated collagen sponges in veterinary orthopaedics.

scholarly journals Functional and aesthetic reconstruction of a dorsal digital skin defect with a sensory neurotized DMCA III flap

2021 ◽  
Vol 8 (1) ◽  
pp. 102-104
Author(s):  
Martin Aman ◽  
Arne Boecker ◽  
Ulrich Kneser ◽  
Leila Harhaus
Keyword(s):  
Skin Defect

The Oxide Defect of C70250 Alloy

2014 ◽  
Vol 936 ◽  
pp. 1168-1172 ◽  
Author(s):  
Zhong Ping Chen ◽  
Chao Jian Xiang ◽  
Hua Qing Li
Keyword(s):  
High Temperature Oxidation ◽  
Rolling Process ◽  
Pilot Scale ◽  
Processing Temperature ◽  
Skin Defect ◽  
Test Results ◽  
Temperature Oxidation ◽  
Reducing Atmosphere ◽  
Hot Rolling Process ◽  
Oxide Skin

The oxide skin defect during hot rolling process for Cu-Ni-Si alloy strip was investigated. Oxide skin defects were analyzed by means of alloy elements detection and microstructures characterization. The characterization and test results showed that high temperature oxidation and silicon segregation are the main causes of the oxide skin defect. Pilot scale tests indicated that hot processing temperature for C70250 alloy should be lower than 950°C. Reducing atmosphere is recommended during the thermal treatment of Cu-Ni-Si alloys.

scholarly journals Cerium-Containing N-Acetyl-6-Aminohexanoic Acid Formulation Accelerates Wound Reparation in Diabetic Animals

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 834
Author(s):  
Ekaterina Blinova ◽  
Dmitry Pakhomov ◽  
Denis Shimanovsky ◽  
Marina Kilmyashkina ◽  
Yan Mazov ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wound Healing ◽  
Topical Therapy ◽  
Skin Defect ◽  
Ki 67 ◽  
Fgfr3 Gene ◽  
White Rats ◽  
Tnf Α ◽  
Acid Formulation ◽  
Healing Property

Background: The main goal of our study was to explore the wound-healing property of a novel cerium-containing N-acethyl-6-aminohexanoate acid compound and determine key molecular targets of the compound mode of action in diabetic animals. Methods: Cerium N-acetyl-6-aminohexanoate (laboratory name LHT-8-17) as a 10 mg/mL aquatic spray was used as wound experimental topical therapy. LHT-8-17 toxicity was assessed in human skin epidermal cell culture using (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. A linear wound was reproduced in 18 outbred white rats with streptozotocin-induced (60 mg/kg i.p.) diabetes; planar cutaneous defect was modelled in 60 C57Bl6 mice with streptozotocin-induced (200 mg/kg i.p.) diabetes and 90 diabetic db/db mice. Firmness of the forming scar was assessed mechanically. Skin defect covering was histologically evaluated on days 5, 10, 15, and 20. Tissue TNF-α, IL-1β and IL-10 levels were determined by quantitative ELISA. Oxidative stress activity was detected by Fe-induced chemiluminescence. Ki-67 expression and CD34 cell positivity were assessed using immunohistochemistry. FGFR3 gene expression was detected by real-time PCR. LHT-8-17 anti-microbial potency was assessed in wound tissues contaminated by MRSA. Results: LHT-8-17 4 mg twice daily accelerated linear and planar wound healing in animals with type 1 and type 2 diabetes. The formulated topical application depressed tissue TNF-α, IL-1β, and oxidative reaction activity along with sustaining both the IL-10 concentration and antioxidant capacity. LHT-8-17 induced Ki-67 positivity of fibroblasts and pro-keratinocytes, upregulated FGFR3 gene expression, and increased tissue vascularization. The formulation possessed anti-microbial properties. Conclusions: The obtained results allow us to consider the formulation as a promising pharmacological agent for diabetic wound topical treatment.

Skin defect in a bedbound patient

BMJ ◽  
2011 ◽  
Vol 342 (may18 2) ◽  
pp. d874-d874
Author(s):  
A. W. N. Reid ◽  
O. P. Shelley
Keyword(s):  
Skin Defect

Surgical treatment of soft tissue sarcomas

1980 ◽  
Vol 61 (6) ◽  
pp. 4-6
Author(s):  
M. Z. Sigal ◽  
G. F. Fatuhova
Keyword(s):  
Surgical Treatment ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Skin Defect ◽  
Skin Grafts ◽  
Preoperative Examination

In 46 patients with sarcomas, extensive soft tissue resections were performed using free skin defect plasty. The limits of resection were determined on the basis of preoperative examination, examination and palpation of various tissue layers during the operation. Defects were replaced with free skin grafts ranging in size from 40 to 300 cm2.

scholarly journals Efficiency of Enzymatic Debridement in the Healing Process of Chronic Wounds in Small Animal Practice

2017 ◽  
Vol 61 (1) ◽  
pp. 38-42 ◽  
Author(s):  
L. Hamilton ◽  
M. Kožár
Keyword(s):  
Chronic Wounds ◽  
Healing Process ◽  
Small Animal ◽  
Skin Defect ◽  
Skin Wounds ◽  
Macroscopic Appearance ◽  
Enzyme Preparations ◽  
Chronic Skin ◽  
The Individual ◽  
Enzymatic Debridement

Abstract Skin wounds are a common presentation in small animal practice. These wounds may be acute or chronic with a complicated healing process. An important aspect of the healing of wounds is debridement which may be carried out by surgical, autolytic, mechanical or enzymatic methods. The debridement method is chosen according to the individual skin defect and influenced by factors such as wound size and location, the age of the wound, and the presence of infection or exudate. Enzymatic debridement is a method that is not commonly used in veterinary practice, and involves the use of enzyme preparations to remove necrotic tissue from a wound. The aim of this study was to investigate the effects of the enzymatic ointment collagenase as a method of debridement, and its effect on the macroscopic appearance of chronic skin wounds in cats and dogs. We observed that the application of Iruxol Mono directly to the wound changes the progress of the healing process, with no obvious adverse effects. The time of healing of chronic wounds was decreased and healthy granulation tissue was developed within a couple of days after application of the ointment. Enzymatic debridement appears to be a promising method of debridement for use in chronic wounds, and should be considered in cases where more conventional methods of debridement are ineffective or unsuitable.

The Use of Engineered Bilayered Skin (MyDermTM) in the Management of Massive Skin Defect in Grade III Gustilo-Anderson Open Fracture

2017 ◽  
Vol 16 (3) ◽  
pp. 212-216
Author(s):  
Nor Hazla Mohamed Haflah ◽  
Min Hwei Ng ◽  
Mohd Heikal Mohd Yunus ◽  
Amaramalar Selvee Naicker ◽  
Ohnmar Htwe ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Open Fracture ◽  
Wound Closure ◽  
Posterior Tibial Artery ◽  
Soft Tissue Coverage ◽  
Skin Defect ◽  
Vascular Repair ◽  
Posterior Compartment ◽  
Large Defect ◽  
Large Skin

Open fracture Gustilo-Anderson grade IIIC is associated with higher risk of infection and problems with soft tissue coverage. Various methods have been used for soft tissue coverage in open fractures with large skin defect. We report a case of a patient who had grade IIIC open fracture of the tibia with posterior tibial artery injury. The patient underwent external fixation and reduction. Because of potential compartment syndrome after vascular repair, fasciotomy of the posterior compartment was performed. This wound, however, became infected and because of further debridement, gave rise to a large skin defect. A tissue engineered skin construct, MyDermTM was employed to cover this large defect. Complete wound closure was achieved 35 days postimplantation. The patient then underwent plating of the tibia for nonunion with no adverse effect to the grafted site. The tibia eventually healed 5 months postplating, and the cosmetic appearance of the newly formed skin was satisfactory.

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