Effect of antenatal azithromycin forUreaplasma spp. on neonatal outcome at ≤30 weeks' gestational age

Background: Preterm premature rupture of membranes (PPROM) predisposes the mother for chorioamnionitis, endometritis, bacteremia and neonate to preterm delivery related complication. There is often dilemma regarding the management of PPROM in mothers with gestational age (GA) <34 weeks.Methods: A retrospective cohort study conducted in a tertiary care hospital over two year period. Neonates delivered before 34 weeks were enrolled and categorized into active management (AM) and expectant management (EM) group. Associated risk factors, duration of PPROM and latency period, Neonatal outcomes like sepsis, morbidity, duration of respiratory support, duration of NICU stay compared between groups.Results: Out of total 197 cases, AM group had 91 babies. Active management resulted in earlier delivery [mean GA (SD): 30.88(1.8) VS 31(2.1) weeks], higher number of caesarian section (76.9% versus 53.8%), lesser birth weight {1233.6 (±282.9) versus 1453.39 (±380.6) gm} and more ELBW babies (23.1% versus 7.5%). EM resulted in significantly higher antenatal steroid cover (73.6% in AM versus 89.6% in EM) and lesser need of surfactant for RDS [42.9% versus 28.3%]. Significant difference was found for NICU stay days {mean (SD): 25.46 (16.8) versus 20.94 (17.5)}. No difference found between respiratory support days [median (IQR) 2 (0, 6) versus 2 (0, 7)]. No significant differences found in incidence of maternal chorioamnionitis, NEC, sepsis, BPD and ROP. Early delivery resulted in higher mortality though that was statistically not significant.Conclusions: Gestational age at delivery is more important predictor of neonatal outcome then PPROM in early preterm.

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425: Multi-vessel Doppler parameters for the prediction of adverse neonatal outcome in the preterm growth-restricted fetus: does gestational age matter?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2012.10.591 ◽

2013 ◽

Vol 208 (1) ◽

pp. S186

Author(s):

Katherine Goetzinger ◽

Alison Cahill ◽

Linda Odibo ◽

George Macones ◽

Anthony Odibo

Keyword(s):

Gestational Age ◽

Neonatal Outcome ◽

Adverse Neonatal Outcome

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Placental pathology and neonatal outcome in small for gestational age pregnancies with and without abnormal umbilical artery Doppler flow

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2018.01.009 ◽

2018 ◽

Vol 222 ◽

pp. 52-56 ◽

Cited By ~ 5

Author(s):

Hadas Ganer Herman ◽

Elad Barber ◽

Rose Gasnier ◽

Liat Gindes ◽

Jacob Bar ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Umbilical Artery ◽

Neonatal Outcome ◽

Placental Pathology ◽

Doppler Flow ◽

Umbilical Artery Doppler

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Correlation study between increased fetal movement during the third trimester and neonatal outcome

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2637-4 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Cuiqin Huang ◽

Wei Han ◽

Yajing Fan

Keyword(s):

Amniotic Fluid ◽

Pregnant Women ◽

Gestational Age ◽

Neonatal Outcome ◽

Stress Test ◽

Neonatal Outcomes ◽

Control Group ◽

Third Trimester ◽

The Third ◽

Fetal Movements

Abstract Background We aimed to analyze the correlation between increased fetal movements in the third trimester and neonatal outcomes. Methods We enrolled pregnant women (n = 219) who reported increased/excessive fetal movements in the third trimester in our hospital. A control group of healthy women (n = 278) who had undergone regular childbirth and delivery in our hospital during the same period and did not report abnormal fetal movements were also recruited. All pregnant women underwent fetal non-stress test. We analyzed the neonatal weight, appearance, pulse, grimace, activity, and respiration score, degrees of amniotic fluid contamination, amniotic fluid volume, conditions of umbilical cord around the neck and cord length, and incidence of small for gestational age. In addition, the incidence of preterm delivery, cesarean section rate, postpartum hemorrhage, and other postpartum complications were also analyzed. We then analyzed the correlation between increased/excessive fetal activity and neonatal outcomes. Results Women with complaints of increased/excessive fetal movements exhibited increased fetal movements mainly around 31 and 39 weeks of gestation. Several pregnancy variables, including number of previous delivery, gestational age (less than 34 weeks and more than 37 weeks) and vaginal birth rate, were associated with increased/excessive fetal movements. In addition, women who reported increased/excessive fetal movements had higher odds of large for gestational age (LGA), particularly those with gestational age over 37 weeks. Conclusion Increased/excessive fetal movements may be used to predict adverse neonatal outcome such as LGA.

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Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome?

Fetal Diagnosis and Therapy ◽

10.1159/000499580 ◽

2019 ◽

Vol 46 (4) ◽

pp. 274-284 ◽

Cited By ~ 2

Author(s):

Manouk L.E. Hendrix ◽

Judith A.P. Bons ◽

Roy R.G. Snellings ◽

Otto Bekers ◽

Sander M.J. van Kuijk ◽

...

Keyword(s):

Fetal Growth ◽

Gestational Age ◽

Small For Gestational Age ◽

Growth Velocity ◽

Neonatal Outcome ◽

First Trimester ◽

Adverse Neonatal Outcome

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Correlation between Clinical, Placental Histology and Microbiological Findings in Spontaneous Preterm Births

Fetal Diagnosis and Therapy ◽

10.1159/000441518 ◽

2015 ◽

Vol 40 (2) ◽

pp. 141-149 ◽

Cited By ~ 6

Author(s):

Gali Garmi ◽

Marina Okopnik ◽

Yoram Keness ◽

Noah Zafran ◽

Elad Berkowitz ◽

...

Keyword(s):

Gestational Age ◽

Neonatal Outcome ◽

Preterm Births ◽

Neonatal Morbidity ◽

Spontaneous Preterm Birth ◽

Retrospective Case ◽

Delivery Methods ◽

Main Determinant ◽

Gestational Age At Delivery ◽

The Impact

Aims: To examine the occurrence of chorioamnionitis and abruption among women who had a spontaneous preterm birth (SPTB), the correlation between clinical and placental findings, and the impact of these complications on neonatal outcome after delivery. Methods: This was a retrospective case-control study conducted between 2008 and 2012 at a single teaching hospital. The study group included all women who had an SPTB (23-36 weeks). Placentas were cultured and underwent histological examination. Results: A total of 478 women were included. The mean gestational age at delivery was 32.6 ± 3.1 weeks. Overall, 260 (54.4%) women had either clinical and/or histological abruption or chorioamnionitis. Clinical chorioamnionitis was diagnosed before birth in 14 (2.9%) women, while histological chorioamnionitis (HCA) in 84 (17.4%). Overall, 38 neonates had infection. Placental cultures were negative in 65.8% (25/38) of these neonates, and in 77.1% (27/38), HCA was ruled out. Logistic regression analysis revealed that neonatal morbidity and mortality were correlated with gestational age at delivery (p = 0.02), not with placental pathology (p = 0.08). Conclusions: Half of the women with PTB had clinical or histological abruption, chorioamnionitis or both. A partial correlation was found between clinical and placental findings. The main determinant of neonatal outcome was gestational age at delivery and not placental findings.

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