Objective:To evaluate inuence of volumetric tumor doubling time on survival of patients with intracranial tumors.
Study design: 20 patients with intracranial tumor of either sex and any age were included, if two imaging scans were available/could be done in
which change in tomor volume was appreciable and the tumor margins were well demarcated. Based on change in tumor volume, tumor doubling
time (DT) and predictive survival time (PST) were calculated. Patients were followed up for 6 months or longer for actual survival time (AST).
Results: The histological grade was found to have a signicant correlation with DT (P value 0.046) and PST of the tumor (P value 0.038). DT and
PSTwere found to be signicantly lower in high grade astrocytomas. Age, gender, tumor location and initial tumor volume were not found to have a
signicant correlation with DTand PST. When DTwas compared to PST, excellent correlation was seen which was statistically signicant (Pvalue
< 0.001) and suggested a linear relationship.
Conclusion: Computed Tomography (CT) & Magnetic Resonance Imaging (MRI) can accurately dene the intracranial tumors and can reliably
measure their volume. Calculation of tumor volume, change in tumor volume, DT and PST based on imaging studies is easy and reproducible. DT
and PST have an excellent correlation & there is a linear relationship between the two. Histological grade and DT are the signicant prognostic
factors while age, gender, tumor location and initial tumor volume are not signicant prognostic factors in patients with brain tumors.
Irradiance, Photofrin
®
Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models
