scholarly journals Decreased levels of endocytic collagen receptor Endo180 in dermal fibroblasts lead to decreased production of type I collagen and increased expression of matrix metalloproteinase‐1

2021 ◽  
Author(s):  
Hiroyasu Iwahashi ◽  
Yoshihito Kawashima ◽  
Hitoshi Masaki
Keyword(s):  
Matrix Metalloproteinase ◽  
Type I Collagen ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Matrix Metalloproteinase 1 ◽  
Collagen Receptor

scholarly journals Effects of Hepatocyte Growth Factor on the Expression of Type I Collagen and Matrix Metalloproteinase-1 in Normal and Scleroderma Dermal Fibroblasts

2005 ◽  
Vol 124 (2) ◽  
pp. 324-330 ◽  
Author(s):  
Masatoshi Jinnin ◽  
Hironobu Ihn ◽  
Yoshihiro Mimura ◽  
Yoshihide Asano ◽  
Kenichi Yamane ◽  
...  
Keyword(s):  
Growth Factor ◽  
Matrix Metalloproteinase ◽  
Hepatocyte Growth Factor ◽  
Type I Collagen ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Matrix Metalloproteinase 1 ◽  
Hepatocyte Growth

scholarly journals A Novel Host/Tumor Cell Interaction Activates Matrix Metalloproteinase 1 and Mediates Invasion through Type I Collagen

1999 ◽  
Vol 274 (36) ◽  
pp. 25371-25378 ◽  
Author(s):  
Ulrike Benbow ◽  
Matthias P. Schoenermark ◽  
Teresa I. Mitchell ◽  
Joni L. Rutter ◽  
Ken-ichi Shimokawa ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Tumor Cell ◽  
Type I Collagen ◽  
Cell Interaction ◽  
Type I ◽  
Matrix Metalloproteinase 1 ◽  
Novel Host

Cumulative Influence of Matrix Metalloproteinase-1 and -2 in the Migration of Melanoma Cells within Three-Dimensional Type I Collagen Lattices

2001 ◽  
Vol 270 (1) ◽  
pp. 110-118 ◽  
Author(s):  
Carole Ntayi ◽  
Sandrine Lorimier ◽  
Odile Berthier-Vergnes ◽  
William Hornebeck ◽  
Philippe Bernard
Keyword(s):  
Matrix Metalloproteinase ◽  
Type I Collagen ◽  
Three Dimensional ◽  
Melanoma Cells ◽  
Type I ◽  
Matrix Metalloproteinase 1 ◽  
Collagen Lattices

scholarly journals Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

2020 ◽  
Vol 21 (22) ◽  
pp. 8693
Author(s):  
Young Eun Choi ◽  
Min Ji Song ◽  
Mari Hara ◽  
Kyoko Imanaka-Yoshida ◽  
Dong Hun Lee ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Transforming Growth Factor ◽  
Mrna Level ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Cell Physiology ◽  
Type I ◽  
Tenascin C ◽  
Matrix Metalloproteinase 1

Tenascin C (TNC) is an element of the extracellular matrix (ECM) of various tissues, including the skin, and is involved in modulating ECM integrity and cell physiology. Although skin aging is apparently associated with changes in the ECM, little is known about the role of TNC in skin aging. In this study, we found that the Tnc mRNA level was significantly reduced in the skin tissues of aged mice compared with young mice, consistent with reduced TNC protein expression in aged human skin. TNC-large (TNC-L; 330-kDa) and -small (TNC-S; 240-kDa) polypeptides were observed in conditional media from primary dermal fibroblasts. Both recombinant TNC polypeptides, corresponding to TNC-L and TNC-S, increased the expression of type I collagen and reduced the expression of matrix metalloproteinase-1 in fibroblasts. Treatment of fibroblasts with a recombinant TNC polypeptide, corresponding to TNC-L, induced phosphorylation of SMAD2 and SMAD3. TNC increased the level of transforming growth factor-β1 (TGF-β1) mRNA and upregulated the expression of type I collagen by activating the TGF-β signaling pathway. In addition, TNC also promoted the expression of type I collagen in fibroblasts embedded in a three-dimensional collagen matrix. Our findings suggest that TNC contributes to the integrity of ECM in young skin and to prevention of skin aging.

scholarly journals Sesquiterpenes From Oplopanax elatus Stems and Their Anti-Photoaging Effects by Down-Regulating Matrix Metalloproteinase-1 Expression via Anti-Inflammation

2021 ◽  
Vol 9 ◽  
Author(s):  
Jiejing Yan ◽  
Mimi Hao ◽  
Yu Han ◽  
Jingya Ruan ◽  
Dandan Zheng ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Type I Collagen ◽  
Ultraviolet B ◽  
Type I ◽  
Dependent Manner ◽  
Hacat Cells ◽  
Western Blot Assay ◽  
Concentration Dependent Manner ◽  
Matrix Metalloproteinase 1 ◽  
Oplopanax Elatus

In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A–D (1–4), eurylosesquiterpenols E–I (5–9), and ten known ones (10–19) were gained. Their structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. In addition, UVB induced HaCaT cells were used to study their anti-photoaging activities and mechanism. The results consolidated that compounds 7, 11, and 14 could improve the survival rate of HaCaT cells in concentration dependent manner at 10, 25, and 50 μM. Furthermore, western blot assay suggested that all of them could inhibit the expression of matrix metalloproteinase-1 (MMP-1), and increase the level of type I collagen markedly. Compounds 11 and 14 could reduce the phosphorylation of extracellular signal-regulated kinase and p38, respectively. Besides, compounds 7, 11, and 14 could significantly down-regulate the expression of inflammation related protein, such as tumor necrosis factor-α and cyclooxygenase-2, which indicated that they played anti-photoaging activities by reducing MMP-1 expression via down-regulating the production of inflammatory mediators and cytokines in UVB-induced HaCaT cells.

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