scholarly journals Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

Respirology ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 437-444 ◽  
Author(s):  
Martin Thomas Gaugg ◽  
Anna Engler ◽  
Lukas Bregy ◽  
Yvonne Nussbaumer‐Ochsner ◽  
Lara Eiffert ◽  
...  
Thorax ◽  
2021 ◽  
pp. thoraxjnl-2021-217315
Author(s):  
William Whalen ◽  
Mustafa Buyukozkan ◽  
Bethany Moore ◽  
Jong-Seok Moon ◽  
Charles S Dela Cruz ◽  
...  

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.


1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL

1985 ◽  
Vol 4 ◽  
pp. 141-146 ◽  
Author(s):  
K VESTERBERG ◽  
J BERGSTROM ◽  
P FURST ◽  
U LEANDER ◽  
E VINNARS

Diabetes ◽  
1993 ◽  
Vol 42 (12) ◽  
pp. 1868-1877 ◽  
Author(s):  
L. Luzi ◽  
A. S. Petrides ◽  
R. A. De Fronzo

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