scholarly journals Decline in respiratory and cardiac admissions during the COVID ‐19 pandemic: What is the role of common respiratory virus infections?

Respirology ◽  
2021 ◽  
Author(s):  
Chloe I. Bloom ◽  
Sebastian L. Johnston

2014 ◽  
Vol 128 (6) ◽  
pp. 337-347 ◽  
Author(s):  
Nathalie Grandvaux ◽  
Mélissa Mariani ◽  
Karin Fink

Determining the role of NADPH oxidases in the context of virus infection is an emerging area of research and our knowledge is still sparse. The expression of various isoforms of NOX/DUOX (NADPH oxidase/dual oxidase) in the epithelial cells (ECs) lining the respiratory tract renders them primary sites from which to orchestrate the host defence against respiratory viruses. Accumulating evidence reveals distinct facets of the involvement of NOX/DUOX in host antiviral and pro-inflammatory responses and in the control of the epithelial barrier integrity, with individual isoforms mediating co-operative, but surprisingly also opposing, functions. Although in vivo studies in mice are in line with some of these observations, a complete understanding of the specific functions of epithelial NOX/DUOX awaits lung epithelial-specific conditional knockout mice. The goal of the present review is to summarize our current knowledge of the role of individual NOX/DUOX isoforms expressed in the lung epithelium in the context of respiratory virus infections so as to highlight potential opportunities for therapeutic intervention.





PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252963
Author(s):  
Min-Chul Kim ◽  
Oh Joo Kweon ◽  
Yong Kwan Lim ◽  
Seong-Ho Choi ◽  
Jin-Won Chung ◽  
...  

During the coronavirus disease (COVID-19) pandemic, social distancing was effective in controlling disease spread across South Korea. The impact of national social distancing on the spread of common respiratory virus infections has rarely been investigated. We evaluated the weekly proportion of negative respiratory virus polymerase chain reaction (PCR) test results and weekly positive rates of each respiratory virus during the social distancing period (10th–41st weeks of 2020) and the corresponding period in different years, utilizing the national respiratory virus surveillance dataset reported by the Korean Center for Disease Control and Prevention. The proportions of negative respiratory virus PCR test results increased up to 87.8% and 86.1% during level 3 and level 2 of the social distancing period, respectively. The higher the level of social distancing, the higher the proportion of negative respiratory virus PCR test results. During the social distancing period, the mean weekly positive rates for parainfluenza virus, influenza virus, human coronavirus, and human metapneumovirus were significantly lower than those during the same period in 2015–2019 (0.1% vs. 9.3%, P <0.001; 0.1% vs. 7.2%, P <0.001; 0.4% vs. 2.3%, P <0.001; and 0.2% vs. 5.3%, P <0.001, respectively). The mean positive rate for rhinovirus/enterovirus during level 3 social distancing was lower than that in the same period in 2015–2019 (8.5% vs. 19.0%, P <0.001), but the rate during level 1 social distancing was higher than that in the same period in 2015–2019 (38.3% vs. 19.4%, P <0.001). The national application of social distancing reduced the spread of common respiratory virus infections during the COVID-19 pandemic.



2001 ◽  
Vol 72 (8) ◽  
pp. 1460-1463 ◽  
Author(s):  
Suparno Chakrabarti ◽  
Kathryn E. Collingham ◽  
Timothy Marshall ◽  
Kathleen Holder ◽  
Trudy Gentle ◽  
...  


2021 ◽  
Vol 02 (01) ◽  
pp. 005-011
Author(s):  
Sanjeev Davey

Background & Object൴ves: The Immune-modulat൴ng Nutr൴t൴onal Supplements based on Grapeseeds r൴ch ൴n Sterols and V൴tam൴ns can be useful ൴n Management of Resp൴ratory V൴ral ൴nfect൴ons ൴nclud൴ng COVID 19, but stud൴es reveal൴ng the൴r comb൴ned eff ects are lack൴ng ൴n l൴terature. Therefore the German manufactured Oro-Nasal Immune spray (NAFLAN- A Nutr൴t൴onal Supplements Product) based on comb൴nat൴on of Plant Sterols & V൴tam൴n, B, D, E needs urgent explorat൴on ൴n context of Preva൴l൴ng COVID 19 Pandem൴c across the world ൴nclud൴ng Ind൴a. Methods: Th൴s cl൴n൴cal tr൴al was done on 40 healthy Volunteers, as part of a Phase 1 tr൴al Project of Pure Derm GmBH, Germany for ൴ts evaluat൴on ൴n Management of Resp൴ratory Infect൴ons ൴nclud൴ng COVID 19. The volunteers were selected from an NGO Hosp൴tal and th൴s tr൴al was enrolled at CTRI ICMR Ind൴a and conducted accord൴ng to WHO, PATH & CONSORT gu൴del൴nes . Tr൴al was done from 15th March 2021- 15th June 2021 ൴n wh൴ch th൴s Immune spray was used for 1 month (1st May 2021- 31st May). Th൴s Cl൴n൴cal tr൴al ൴ncluded all types of COVID 19 ൴nclud൴ng Ind൴an Mutat൴on Delta Var൴ant. Results: Symptoms such as Cough and D൴arrhoea were reduced s൴gn൴f൴cantly after use of Immune( Nafl an Spray) [χ2 =9.25 (Yates Correct൴on), P <0.05, RR Adjusted=1.8, 95% C.I=1.5-2.1], but no eff ect on h൴gh fever, headache, and Common cold were seen. Interpretation & Conclusions: Nafalan Spray can be useful in Prevention of Cough in Respiratory Infections (possibly also COVID 19). However Large scale Multicentric trial is however advocated by authors before reaching a more defi nite conclusion of role of Nafalan Spray in Prevention of COVID 19 Infection.



2019 ◽  
Vol 11 (5) ◽  
pp. 331-333 ◽  
Author(s):  
Peter J Hotez

Abstract Over the last decade we have seen extraordinary public health gains due to expansions in global vaccination programs led by United Nations (UN) agencies, including Gavi, the Vaccine Alliance, UNICEF and the WHO. These initiatives have reduced childhood deaths from measles, tetanus and other vaccine-preventable diseases by almost one half. There is additional excitement over the potential development and introduction of new vaccines to prevent highly lethal respiratory virus infections, as well as tuberculosis, malaria, HIV/AIDS and several neglected tropical diseases. However, these successes are under threat due to political instability, conflict and an accelerating antivaccine movement. New initiatives in vaccine diplomacy will be required to combat these challenges.



Author(s):  
Heather W Dolby ◽  
Philippe M D Potey ◽  
Annika Wilder-Smith ◽  
Sara Clohisey ◽  
Jonathan E Millar ◽  
...  

Abstract Pulmonary micro-thrombosis and vasculitis occur in fatal COVID-19. To determine if these processes occur in other life-threatening respiratory virus infections we identified autopsy studies of fatal influenza(n=455 patients), SARS(n=37), MERS(n=2), adenovirus(n=34) and RSV(n=30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.





2021 ◽  
pp. 104795
Author(s):  
Monika Redlberger-Fritz ◽  
Michael Kundi ◽  
Stephan W Aberle ◽  
Elisabeth Puchhammer-Stöckl


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