scholarly journals Short‐term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis

Respirology ◽  
2022 ◽  
Author(s):  
Claudio Macaluso ◽  
Cristina Boccabella ◽  
Maria Kokosi ◽  
Nishanth Sivarasan ◽  
Vasilis Kouranos ◽  
...  
Keyword(s):  
Lung Function ◽  
Hypersensitivity Pneumonitis ◽  
Short Term

scholarly journals P145 Marginal short term lung function changes predict mortality in patients with fibrotic hypersensitivity pneumonitis

2021 ◽  
Author(s):  
C Macaluso ◽  
C Boccabella ◽  
M Kokosi ◽  
V Kouranos ◽  
PM George ◽  
...  
Keyword(s):  
Lung Function ◽  
Hypersensitivity Pneumonitis ◽  
Short Term

“Impact of Smoking Cessation Treatment” on Lung Function and Response Rate in EGFR Mutated Patients: A Short-Term Cohort Study

2015 ◽  
Vol 10 (3) ◽  
pp. 342-351 ◽  
Author(s):  
Aldo Pezzuto ◽  
Luciano Stumbo ◽  
Marco Russano ◽  
Pierfilippo Crucitti ◽  
Simone Scarlata ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cohort Study ◽  
Lung Function ◽  
Response Rate ◽  
Short Term ◽  
Smoking Cessation Treatment ◽  
Cessation Treatment ◽  
Egfr Mutated

scholarly journals A short-term evaluation of a prototype disposable Oscillating Positive Expiratory Pressure (OPEP) device in a cohort of children with cystic fibrosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kevin J. O’Sullivan ◽  
Valerie Power ◽  
Barry Linnane ◽  
Deirdre McGrath ◽  
Magdalena Mulligan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Clinical Investigation ◽  
Mean Difference ◽  
Short Term ◽  
Intervention Participant ◽  
Post Intervention ◽  
Convenience Sample ◽  
Disposable Device ◽  
Positive Expiratory Pressure

Abstract Background Oscillating Positive Expiratory Pressure (OPEP) devices are important adjuncts to airway clearance therapy in patients with cystic fibrosis (CF). Current devices are typically reusable and require daily, or often more frequent, cleaning to prevent risk of infection by acting as reservoirs of potentially pathogenic organisms. In response, a daily disposable OPEP device, the UL-OPEP, was developed to mitigate the risk of contamination and eliminate the burdensome need for cleaning devices. Methods A convenience sample of 36 participants, all current OPEP device users, was recruited from a paediatric CF service. For one month, participants replaced their current OPEP device with a novel daily disposable device. Assessment included pre- and post-intervention lung function by spirometry, as well as Lung Clearance Index. Quality of life was assessed using the Cystic Fibrosis Questionnaire – Revised, while user experience was evaluated with a post-study survey. Results 31 participants completed the study: 18 males; median age 10 years, range 4–16 years. Lung function (mean difference ± SD, %FEV1 = 1.69 ± 11.93; %FVC = 0.58 ± 10.04; FEV1: FVC = 0.01 ± 0.09), LCI (mean difference ± SD, 0.08 ± 1.13), six-minute walk test, and CFQ-R were unchanged post-intervention. Participant-reported experiences of the device were predominantly positive. Conclusions The disposable OPEP device maintained patients’ lung function during short term use (≤ 1 month), and was the subject of positive feedback regarding functionality while reducing the risk of airway contamination associated with ineffective cleaning. Registration The study was approved as a Clinical Investigation by the Irish Health Products Regulatory Authority (CRN-2209025-CI0085).

scholarly journals Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis

2017 ◽  
Vol 3 (3) ◽  
pp. 00016-2017 ◽  
Author(s):  
Ayodeji Adegunsoye ◽  
Justin M. Oldham ◽  
Evans R. Fernández Pérez ◽  
Mark Hamblin ◽  
Nina Patel ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Lung Function ◽  
Adverse Events ◽  
Immunosuppressive Therapy ◽  
Hypersensitivity Pneumonitis ◽  
Pulmonary Function Tests ◽  
Lung Function Decline ◽  
Azathioprine Therapy ◽  
Free Survival ◽  
Chronic Hypersensitivity Pneumonitis

In chronic hypersensitivity pneumonitis (CHP), lack of improvement or declining lung function may prompt use of immunosuppressive therapy. We hypothesised that use of azathioprine or mycophenolate mofetil with prednisone reduces adverse events and lung function decline, and improves transplant-free survival.Patients with CHP were identified. Demographic features, pulmonary function tests, incidence of treatment-emergent adverse events (TEAEs) and transplant-free survival were characterised, compared and analysed between patients stratified by immunosuppressive therapy. A multicentre comparison was performed across four independent tertiary medical centres.Among 131 CHP patients at the University of Chicago medical centre (Chicago, IL, USA), 93 (71%) received immunosuppressive therapy, and had worse baseline forced vital capacity (FVC) and diffusing capacity, and increased mortality compared with those who did not. Compared to patients treated with prednisone alone, TEAEs were 54% less frequent with azathioprine therapy (p=0.04) and 66% less frequent with mycophenolate mofetil (p=0.002). FVC decline and survival were similar between treatment groups. Analyses of datasets from four external tertiary medical centres confirmed these findings.CHP patients who did not receive immunosuppressive therapy had better survival than those who did. Use of mycophenolate mofetil or azathioprine was associated with a decreased incidence of TEAEs, and no difference in lung function decline or survival when compared with prednisone alone. Early transition to mycophenolate mofetil or azathioprine may be an appropriate therapeutic approach in CHP, but more studies are needed.

Mechanism of short-term improvement in lung function after emphysema resection.

1996 ◽  
Vol 154 (4) ◽  
pp. 945-951 ◽  
Author(s):  
A F Gelb ◽  
N Zamel ◽  
R J McKenna ◽  
M Brenner
Keyword(s):  
Lung Function ◽  
Short Term

Short-Term Variation in Air Pollution and in Average Lung Function Among Never-Smokers

2001 ◽  
Vol 163 (2) ◽  
pp. 356-361 ◽  
Author(s):  
CHRISTIAN SCHINDLER ◽  
NINO KÜNZLI ◽  
JEAN-PIERRE BONGARD ◽  
PHILIPPE LEUENBERGER ◽  
WERNER KARRER ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Short Term ◽  
Term Variation ◽  
Never Smokers

Association between lung function of school age children and short-term exposure to air pollution and pollen: the PARIS cohort

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215515
Author(s):  
Hélène Amazouz ◽  
Nicolas Bougas ◽  
Michel Thibaudon ◽  
Guillaume Lezmi ◽  
Nicole Beydon ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
School Age Children ◽  
School Age ◽  
Short Term ◽  
Short Term Exposure ◽  
Air Pollution Exposure ◽  
Total Pollen ◽  
Pollution Exposure ◽  
Cluster 2

BackgroundDaily levels of ambient air pollution and pollen may affect lung function but have rarely been studied together. We investigated short-term exposure to pollen and air pollution in relation to lung function in school-age children from a French population-based birth cohort.MethodsThis study included 1063 children from the PARIS (Pollution and Asthma Risk: an Infant Study) cohort whose lung function and FeNO measurements were performed at age 8 years old. Exposure data were collected up to 4 days before testing. We estimated daily total pollen concentration, daily allergenic risk indices for nine pollen taxa, as well as daily concentrations of three air pollutants (particulate matter less than 10 µm (PM10), nitrogen dioxide (NO2), ozone (O3)). Children with similar pollen and air pollution exposure were grouped using multidimensional longitudinal cluster analysis. Associations between clusters of pollen and air pollution exposure and respiratory indices (FEV1, FVC, FeNO) were studied using multivariable linear and logistic regression models adjusted for potential confounders.ResultsFour clusters of exposure were identified: no pollen and low air pollution (Cluster 1), grass pollen (Cluster 2), PM10 (Cluster 3) and birch/plane-tree pollen with high total pollen count (Cluster 4). Compared with children in Cluster 1, children in Cluster 2 had significantly lower FEV1 and FVC levels, and children from Cluster 3 had higher FeNO levels. For FEV1 and FVC, the associations appeared stronger in children with current asthma. Additional analysis suggested a joint effect of grass pollen and air pollution on lung function.ConclusionDaily ambient chemical and biological air quality could adversely influence lung function in children.

scholarly journals Feather duvet lung

2019 ◽  
Vol 12 (11) ◽  
pp. e231237 ◽  
Author(s):  
Patrick Liu-Shiu-Cheong ◽  
Chris RuiWen Kuo ◽  
Struan WA Wilkie ◽  
Owen Dempsey
Keyword(s):  
Lung Function ◽  
Hypersensitivity Pneumonitis ◽  
Oral Corticosteroid ◽  
Gas Transfer ◽  
Mosaic Pattern ◽  
Pet Birds ◽  
History Of ◽  
Function Testing ◽  
Oral Corticosteroid Therapy ◽  
Restrictive Pattern

A 43-year-old non-smoker was referred with a 3-month history of malaise, fatigue and breathlessness. Blood avian precipitins were strongly positive. Lung function testing confirmed a restrictive pattern with impaired gas transfer. A ‘ground glass’ mosaic pattern was seen on CT imaging, suggestive of hypersensitivity pneumonitis. Although he had no pet birds, on closer questioning he had recently acquired a duvet and pillows containing feathers. His symptoms, chest radiograph and lung function tests improved after removal of all feather bedding, and he was also started on oral corticosteroid therapy. Our case reinforces the importance of taking a meticulous exposure history and asking about domestic bedding in patients with unexplained breathlessness. Prompt recognition and cessation of antigen exposure may prevent the development of irreversible lung fibrosis.

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