A rare case of mixed type liposarcoma of breast arising in malignant phyllodes tumor

Abstract Background Granulocyte-colony stimulating factor (G-CSF)-producing tumors can cause leukocytosis despite an absence of infection. G-CSF-producing tumors have been reported in various organs such as the lung, esophagus, and stomach but rarely in the breast. We report a case of G-CSF-producing malignant phyllodes tumor of the breast. Case presentation An 84-year-old woman visited our hospital complaining of a lump in her left breast without fever and pain. Laboratory tests revealed elevated white blood cell (WBC) count and G-CSF levels. A malignant tumor of the breast was diagnosed by core needle biopsy. We performed a total mastectomy and sentinel lymph node biopsy. The tumor was identified as a G-CSF-producing malignant phyllodes tumor. Within 7 days after surgery, the patient’s WBC count and G-CSF level had decreased to normal levels. She is alive without recurrence 13 months after surgery. Conclusions We encountered a rare case of G-CSF-producing malignant phyllodes tumor of the breast. PET–CT revealed diffuse accumulation of FDG in the bone. Phyllodes tumors need to be differentiated from bone metastasis, lymphoma, and leukemia. We must be careful to not mistake this type of tumor for bone marrow metastasis.

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Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature

Case Reports in Oncological Medicine ◽

10.1155/2020/1989452 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Gabriel S. Makar ◽

Michael Makar ◽

Joanna Ghobrial ◽

Kathryn Bush ◽

Ryan Allen Gruner ◽

...

Keyword(s):

Breast Neoplasms ◽

Rare Case ◽

Phyllodes Tumor ◽

Adolescent Females ◽

Small Subset ◽

Review Of The Literature ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

Rare Case Report

Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0.9%) with malignant phyllodes tumors being even more uncommon. Malignant phyllodes tumors tend to progress rapidly though only 1.5% metastasize. They are also associated with a higher rate of recurrence than their benign counterparts, underlying the importance of adequate surgical margins. It is therefore imperative to be able to identify these tumors early allowing for prompt resection and close follow-up. Here, we present the rare case of a 17-year-old female presenting with a rapidly enlarging breast mass, which was ultimately found to be a malignant phyllodes tumor. We further performed a review of the literature to highlight only 22 other cases reported in adolescent females.

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A rare case of a malignant phyllodes tumor of the breast associated with secretion of beta‐human chorionic gonadotropin

The Breast Journal ◽

10.1111/tbj.13383 ◽

2019 ◽

Vol 25 (5) ◽

pp. 984-985

Author(s):

Lauren Andring ◽

Abir Tawil ◽

Rohan Deraniyagala

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Rare Case ◽

Phyllodes Tumor ◽

Malignant Phyllodes Tumor ◽

Beta Human Chorionic Gonadotropin

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Malignant Phyllodes Tumor of the Breast With Metastasis to the Orbit: A Rare Case Report

Ophthalmic Plastic and Reconstructive Surgery ◽

10.1097/iop.0000000000001693 ◽

2020 ◽

Vol 37 (1) ◽

pp. e5-e7

Author(s):

Vijitha S Vempuluru ◽

Dilip K Mishra ◽

Swathi Kaliki

Keyword(s):

Case Report ◽

Rare Case ◽

Phyllodes Tumor ◽

Malignant Phyllodes Tumor ◽

Rare Case Report

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Malignant phyllodes tumor with heterologous differentiation: A rare case report

Journal of Cancer Research and Therapeutics ◽

10.4103/0973-1482.137996 ◽

2015 ◽

Vol 11 (3) ◽

pp. 651 ◽

Cited By ~ 4

Author(s):

GeetaV Patil Okaly ◽

ClementWilfred Devadass ◽

SudhaHorakerappa Metikurke

Keyword(s):

Case Report ◽

Rare Case ◽

Phyllodes Tumor ◽

Malignant Phyllodes Tumor ◽

Rare Case Report

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MFH Mimic in Breast: A High-Grade Malignant Phyllodes Tumor

Case Reports in Pathology ◽

10.1155/2012/835687 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

A. L. Hemalatha ◽

V. Sumana Sindhuram ◽

U. Asha

Keyword(s):

Malignant Fibrous Histiocytoma ◽

Rare Case ◽

Fibrous Histiocytoma ◽

Osteogenic Sarcoma ◽

Phyllodes Tumor ◽

High Grade ◽

Malignant Phyllodes Tumor ◽

Mesenchymal Tissue

Malignant phyllodes tumor is usually diagnosed by the presence of benign duct-like epithelium and malignant mesenchymal tissue. In addition to the usual fibrosarcomatous features, the mesenchymal component may show areas resembling osteogenic sarcoma, chondrosarcoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, malignant mesenchymoma, and, very rarely, malignant fibrous histiocytoma. We present one such rare case of malignant phyllodes tumor with malignant fibrous histiocytoma-like stromal differentiation.

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Advance Malignant Phyllodes Tumor with Active Bleeding in Children: A Rare Case

Indonesian Journal of Cancer ◽

10.33371/ijoc.v15i4.797 ◽

2021 ◽

Vol 15 (4) ◽

pp. 208

Author(s):

Dedy Hermansyah ◽

Fernando Silalahi ◽

Albiner Simarmata ◽

Denny Rifsal Siregar

Keyword(s):

Physical Examination ◽

Rare Case ◽

Phyllodes Tumor ◽

Active Bleeding ◽

Breast Lesions ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

Prompt Treatment ◽

The Right ◽

Current Guidelines

Introduction: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, there are only a few large pediatric phyllodes tumor series. Current guidelines do not differentiate treatment recommendations between children and adults.Case Presentation: A 12-year-old girl presented with a lump in her right breast which grew rapidly within a month. On physical examination, we found a mass on the right breast sized ± 10 x 10 cm; the lump was fragile and bled easily. The patient’s condition was getting worse and worse. Due to this deterioration, we performed a mastectomy immediately.Conclusions: The incidence of malignant phyllodes tumor in children is very rare and required prompt treatment in emergency cases.

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