Advance Malignant Phyllodes Tumor with Active Bleeding in Children: A Rare Case

Introduction: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, there are only a few large pediatric phyllodes tumor series. Current guidelines do not differentiate treatment recommendations between children and adults.Case Presentation: A 12-year-old girl presented with a lump in her right breast which grew rapidly within a month. On physical examination, we found a mass on the right breast sized ± 10 x 10 cm; the lump was fragile and bled easily. The patient’s condition was getting worse and worse. Due to this deterioration, we performed a mastectomy immediately.Conclusions: The incidence of malignant phyllodes tumor in children is very rare and required prompt treatment in emergency cases.

Download Full-text

Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature

Case Reports in Oncological Medicine ◽

10.1155/2020/1989452 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Gabriel S. Makar ◽

Michael Makar ◽

Joanna Ghobrial ◽

Kathryn Bush ◽

Ryan Allen Gruner ◽

...

Keyword(s):

Breast Neoplasms ◽

Rare Case ◽

Phyllodes Tumor ◽

Adolescent Females ◽

Small Subset ◽

Review Of The Literature ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

Rare Case Report

Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0.9%) with malignant phyllodes tumors being even more uncommon. Malignant phyllodes tumors tend to progress rapidly though only 1.5% metastasize. They are also associated with a higher rate of recurrence than their benign counterparts, underlying the importance of adequate surgical margins. It is therefore imperative to be able to identify these tumors early allowing for prompt resection and close follow-up. Here, we present the rare case of a 17-year-old female presenting with a rapidly enlarging breast mass, which was ultimately found to be a malignant phyllodes tumor. We further performed a review of the literature to highlight only 22 other cases reported in adolescent females.

Download Full-text

Large Malignant Phyllodes Tumor of the Breast: Case Report of a Young Female and Review of Literature

Archives of Breast Cancer ◽

10.32768/abc.202073136-142 ◽

2020 ◽

pp. 137-146

Author(s):

Melissa Kyriakos Saad ◽

Imad El Hajj ◽

Elias Saikaly

Keyword(s):

Malignant Tumors ◽

Pectoralis Major Muscle ◽

Phyllodes Tumor ◽

World Health ◽

Low Grade ◽

Accurate Identification ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

Post Surgery ◽

The Right

Background: Phyllodes tumors are rare fibroepithelial neoplasm of the breast, representing 0.3 to 0.5% of all female breast neoplasms. The term ‘‘phyllodes tumor” by the World Health Organization (WHO) categorizes it into benign, borderline, and malignant tumors based on histopathological characteristics. Malignant phyllodes tumor is an uncommon but aggressive breast malignancy and accounts for approximately 25% of all phyllodes tumors.Case Presentation: A 23-year-old female patient Gravida 0 Para 0, previously healthy, with no family history of breast or ovarian cancer was referred to our institution for managing a right breast mass increasing in size over a period of 1 month associated with reddish-brown discoloration of the skin. Breast ultrasound showed an isodense oval mass measuring approximately 16x14x12cm in the right lower outer quadrant of her breast. Core biopsy and FNA done revealed a low grade phyllodes tumor. MRI of breasts showed a huge mass of the right breast occupying all quadrants, measuring 15x14.5 cm in its greatest axis with involvement of the pectoralis major muscle, with no evidence of suspicious axillary lymphadenopathy. Distant metastatic work-up with CT scan of chest abdomen and pelvis and a PET scan did not show distant metastasis. Hence, the patient underwent right total mastectomy with a final pathology compatible with malignant phyllodes tumor. She is on regular follow up and 18 months post-surgery is still disease free.Conclusion: Management of malignant phyllodes tumor remains debatable, especially when it comes to the effect of adjuvant radiotherapy and chemotherapy. From a surgical perspective, whether phyllodes tumors should be considered as epithelial breast cancers or as soft tissue sarcoma is another debate. On the other hand, although challenging, accurate identification of phyllodes tumor initially may aid in decreased recurrence.

Download Full-text

Effective Treatment of a Malignant Breast Phyllodes Tumor with Doxorubicin-Ifosfamide Therapy

Case Reports in Oncological Medicine ◽

10.1155/2019/2759650 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Shinya Yamamoto ◽

Shigeru Yamagishi ◽

Toshiro Kohno ◽

Ryosuke Tajiri ◽

Toshikazu Gondo ◽

...

Keyword(s):

Pleural Effusion ◽

Left Lung ◽

Phyllodes Tumor ◽

Lung Mass ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors ◽

Malignant Breast ◽

One Year ◽

The Right ◽

Chemotherapy Strategy

Malignant phyllodes tumors of the breast occur infrequently and are difficult to treat with chemotherapy. Here, we present an effective chemotherapy strategy for recurrent malignant breast phyllodes tumors. A 48-year-old woman was diagnosed with a malignant phyllodes tumor in her right breast and underwent total right mastectomy. One year later, the tumor recurred in the right (a 2.2 cm mass) and left (a 10 cm mass) lungs; pleural effusion was also observed in the left lung. Eight courses of doxorubicin-ifosfamide (AI) therapy were administered. After treatment, the right lung mass and pleural effusion regressed completely and the left lung mass regressed to 2 cm. In conclusion, AI therapy is useful for treating recurrent malignant breast phyllodes tumors.

Download Full-text

Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

Surgical Case Reports ◽

10.1186/s40792-021-01113-x ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Kimihisa Mizoguchi ◽

Kazuhisa Kaneshiro ◽

Makoto Kubo ◽

Yoshihiko Sadakari ◽

Yoshizo Kimura ◽

...

Keyword(s):

Rare Case ◽

Phyllodes Tumor ◽

Left Breast ◽

Lymph Node Biopsy ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Malignant Phyllodes Tumor ◽

Csf Levels ◽

Wbc Count ◽

Stimulating Factor

Abstract Background Granulocyte-colony stimulating factor (G-CSF)-producing tumors can cause leukocytosis despite an absence of infection. G-CSF-producing tumors have been reported in various organs such as the lung, esophagus, and stomach but rarely in the breast. We report a case of G-CSF-producing malignant phyllodes tumor of the breast. Case presentation An 84-year-old woman visited our hospital complaining of a lump in her left breast without fever and pain. Laboratory tests revealed elevated white blood cell (WBC) count and G-CSF levels. A malignant tumor of the breast was diagnosed by core needle biopsy. We performed a total mastectomy and sentinel lymph node biopsy. The tumor was identified as a G-CSF-producing malignant phyllodes tumor. Within 7 days after surgery, the patient’s WBC count and G-CSF level had decreased to normal levels. She is alive without recurrence 13 months after surgery. Conclusions We encountered a rare case of G-CSF-producing malignant phyllodes tumor of the breast. PET–CT revealed diffuse accumulation of FDG in the bone. Phyllodes tumors need to be differentiated from bone metastasis, lymphoma, and leukemia. We must be careful to not mistake this type of tumor for bone marrow metastasis.

Download Full-text

Rare Case of Servelle Martorelle Syndrome

Kathmandu University Medical Journal ◽

10.3126/kumj.v10i4.11011 ◽

2014 ◽

Vol 10 (4) ◽

pp. 91-94

Author(s):

A Bhatnagar ◽

M Deshpande

Keyword(s):

Soft Tissue ◽

Upper Limb ◽

Rare Case ◽

Prompt Treatment ◽

Congenital Vascular Malformation ◽

History Of ◽

The Right ◽

Scapular Region

Servelle Martorelle Syndrome is a congenital vascular malformation associated with soft tissue hypertrophy and bony hypoplasia. This rarely involves whole of an extremity, with involvement of part of limbs reported in literature. We present a case of a twelve year boy who presented to the Department of Plastic Surgery SGPGIMS in April 2011 ,with history of circumferential soft tissue hypertrophy involving whole of left upper limb, scapular region and axilla since birth. The entire left upper limb length was lesser than the right upper limb. Hence this is a very rare case of Servelle Martorelle Syndrome having extensive limb involvement at a very young age. Highlighted is the role of conservative treatment and close follow-up to understand the natural history of the diseases, with prompt treatment of complications. DOI: http://dx.doi.org/10.3126/kumj.v10i4.11011 Kathmandu Univ Med J 2012;10(4):91-94

Download Full-text

A rare case of a malignant phyllodes tumor of the breast associated with secretion of beta‐human chorionic gonadotropin

The Breast Journal ◽

10.1111/tbj.13383 ◽

2019 ◽

Vol 25 (5) ◽

pp. 984-985

Author(s):

Lauren Andring ◽

Abir Tawil ◽

Rohan Deraniyagala

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Rare Case ◽

Phyllodes Tumor ◽

Malignant Phyllodes Tumor ◽

Beta Human Chorionic Gonadotropin

Download Full-text

A rare case of mixed type liposarcoma of breast arising in malignant phyllodes tumor

The Breast Journal ◽

10.1111/tbj.13546 ◽

2019 ◽

Vol 26 (2) ◽

pp. 271-273 ◽

Cited By ~ 1

Author(s):

Jae‐Myung Kim ◽

Eun Jung Jung ◽

Ju‐Yeon Kim ◽

Han Shin Lee ◽

Hyo Jung An ◽

...

Keyword(s):

Rare Case ◽

Mixed Type ◽

Phyllodes Tumor ◽

Malignant Phyllodes Tumor

Download Full-text

Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature

Case Reports in Oncological Medicine ◽

10.1155/2018/6491675 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

R. A. Amir ◽

Rola S. Rabah ◽

S. S. Sheikh

Keyword(s):

Case Report ◽

Breast Neoplasms ◽

Distant Metastasis ◽

Case Reports ◽

Phyllodes Tumor ◽

Pancreatic Metastasis ◽

Rare Tumor ◽

Review Of Literature ◽

Malignant Phyllodes Tumor ◽

Phyllodes Tumors

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term “cystosarcoma phyllodes” based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, “cystosarcoma” was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones. Rarely, this tumor metastasizes to other locations. Herein, we report a case of malignant phyllodes tumor with metastasis to the pancreas. According to our knowledge, only 3 case reports of pancreatic metastasis from malignant phyllodes tumor have been reported in literature thus far. We aim to increase awareness among physicians of this rare metastasic potential of the uncommonly encountered malignant phyllodes tumor.

Download Full-text