Risk factors and clinical outcomes of tuberculosis among kidney transplant recipients in high endemic country

2021 ◽  
Author(s):  
Saranya Thitisuriyarax ◽  
Jakapat Vanichanan ◽  
Suwasin Udomkarnjananun ◽  
Natavudh Townamchai ◽  
Kamonwan Jutivorakool
Keyword(s):  
Risk Factors ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Endemic Country ◽  
Kidney Transplant Recipients

Medication Errors and Adverse Drug Events in Kidney Transplant Recipients: Incidence, Risk Factors, and Clinical Outcomes

2012 ◽  
Vol 32 (12) ◽  
pp. 1053-1060 ◽  
Author(s):  
David J. Taber ◽  
Nicole A. Pilch ◽  
Charles F. Bratton ◽  
John W. McGillicuddy ◽  
Kenneth D. Chavin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Medication Errors ◽  
Adverse Drug Events ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Incidence Risk

scholarly journals 1389. Risk Factors and Clinical Outcomes of Tuberculosis Among Kidney Transplant Recipients in High Endemic Country: A Case–Control Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S505-S505
Author(s):  
Saranya Thitisuriyarax ◽  
Kamonwan Jutivorakool ◽  
Suwasin Udomkarnjananun ◽  
Natavudh Townamchai ◽  
Gompol Suwanpimolkul ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Case Control Study ◽  
Latent Infection ◽  
Case Control ◽  
Transplant Recipients ◽  
Endemic Country ◽  
Kidney Transplant Recipients ◽  
Control Study

Abstract Background Tuberculosis (TB) is considered as a challenging issue in solid-organ transplant recipients because of high morbidity and mortality. Active TB after transplant can occur from reactivation of latent infection or newly acquired from community. Understanding risk factors and clinical information of TB may provide an appropriate prevention and treatment strategies in this specific patient population; however, most of data were from non-endemic countries. Methods A single-center, matched case–control study was conducted in our institute. Cases were defined as newly diagnosed proven or probable active TB in patients who underwent kidney transplant between April 1992 and October 2018. For each case, 5 controls were matched by age and sex. Risk factor associated with TB was determined using univariate and multivariate conditional logistic regression. Results Between study period, kidney transplant was performed in 787 patients. None of the recipients was screened or treated for latent tuberculosis. Twenty-seven patients (3.43%) were diagnosed with active TB including 20 proven and 7 probable cases. The overall incidence of TB in our population was 315 cases per 100,000 patients per year. Allograft rejection was significantly associated with active TB (P < 0.001). The median onset of infection was 17 months (IQR, 4–59 months) after transplantation and 3.4 months (IQR, 2.7–16.3 months) after episode of allograft rejection. Majority of patients (96.3%) were cured after complete treatment; however, those with TB remained having significant unfavorable outcomes including higher all-cause mortality and graft loss. Conclusion Incidence of TB in kidney transplant recipients is higher than normal population. Increasing risk of active TB after allograft rejection is probably due to mycobacterial reactivation following high-dose immunosuppression. Since TB is associated with poor post-transplant outcomes, screening, and treatment of latent infection may be beneficial even in endemic country. Disclosures All authors: No reported disclosures.

Risk Factors for Late-Onset Cytomegalovirus Infection or Disease in Kidney Transplant Recipients

2014 ◽  
Vol 97 (5) ◽  
pp. 569-575 ◽  
Author(s):  
Alainna J. Jamal ◽  
Shahid Husain ◽  
Yanhong Li ◽  
Olusegun Famure ◽  
S. Joseph Kim
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Late Onset ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Assessment risk factors and different lines of treatment of anemia in kidney transplant recipients

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mohamed Elsaftawy ◽  
Medhat Mahmoud ◽  
Yaser Elhendy ◽  
Ahmed Akl
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Risk factors for colonization and infection by resistant microorganisms in kidney transplant recipients

2021 ◽  
Vol 74 (suppl 6) ◽  
Author(s):  
Monica Taminato ◽  
Richarlisson Borges de Morais ◽  
Dayana Souza Fram ◽  
Rogério Rodrigues Floriano Pereira ◽  
Cibele Grothe Esmanhoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Length Of Stay ◽  
Kidney Transplant ◽  
Multidrug Resistant ◽  
Morbidity And Mortality ◽  
Epidemiological Surveillance ◽  
Resistant Bacteria ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Tract Infections

ABSTRACT Objectives: to assess the prevalence of colonization and infection by multidrug-resistant bacteria in patients undergoing kidney transplantation and identify the rate of infection, morbidity and mortality and associated risk factors. Methods: a prospective cohort of 200 randomly included kidney transplant recipients. Epidemiological surveillance of the studied microorganisms was carried out in the first 24 hours and 7 days after transplantation. Results: ninety (45%) patients were considered colonized. Female sex, hypertension and diabetes (p<0.005), dialysis time (p<0.004), length of stay after transplantation, delayed renal function, and length of stay were identified as risk factors. The microorganisms were isolated from surgical site, bloodstream and urinary tract infections. Conclusions: colonization by resistant microorganisms in kidney transplant patients was frequent and risk factors associated with infection were identified. The results should guide the care team in order to minimize morbidity and mortality related to infectious causes in this population.

Clinical Outcomes of Older Kidney Transplant Recipients

2021 ◽  
Author(s):  
Maria Aurora Posadas Salas ◽  
Rafael David Rodriguez-Abreu ◽  
Prince Amaechi ◽  
Vinaya Rao ◽  
Karim Soliman ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Everolimus and Long-term Clinical Outcomes in Kidney Transplant Recipients

2019 ◽  
Vol 103 (8) ◽  
pp. 1705-1713 ◽  
Author(s):  
Tracey Ying ◽  
Germaine Wong ◽  
Wai H. Lim ◽  
Philip Clayton ◽  
John Kanellis ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Impact of antiretroviral therapy on clinical outcomes in HIV+ kidney transplant recipients: Review of 58 cases

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2893 ◽  
Author(s):  
Rossana Rosa ◽  
Jose F. Suarez ◽  
Marco A. Lorio ◽  
Michele I. Morris ◽  
Lilian M. Abbo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Acute Rejection ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Graft Survival ◽  
Patient Survival ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Serious Infections ◽  
The Impact

Background: Antiretroviral therapy (ART) poses challenging drug-drug interactions with immunosuppressant agents in transplant recipients.  We aimed to determine the impact of specific antiretroviral regimens in clinical outcomes of HIV+ kidney transplant recipients. Methods: A single-center, retrospective cohort study was conducted at a large academic center. Subjects included 58 HIV- to HIV+ adult, first-time kidney transplant patients. The main intervention was ART regimen used after transplantation.  The main outcomes assessed at one- and three-years were: patient survival, death-censored graft survival, and biopsy-proven acute rejection; we also assessed serious infections within the first six months post-transplant. Results: Patient and graft survival at three years were both 90% for the entire cohort. Patients receiving protease inhibitor (PI)-containing regimens had lower patient survival at one and three years than patients receiving PI-sparing regimens: 85% vs. 100% (p=0.06) and 82% vs. 100% (p=0.03), respectively. Patients who received PI-containing regimens had twelve times higher odds of death at 3 years compared to patients who were not exposed to PIs (odds ratio, 12.05; 95% confidence interval, 1.31-1602; p=0.02).  Three-year death-censored graft survival was lower in patients receiving PI vs. patients on PI-sparing regimens (82 vs 100%, p=0.03). Patients receiving integrase strand transfer inhibitors-containing regimens had higher 3-year graft survival. There were no differences in the incidence of acute rejection by ART regimen. Individuals receiving PIs had a higher incidence of serious infections compared to those on PI-sparing regimens (39 vs. 8%, p=0.01). Conclusions: PI-containing ART regimens are associated with adverse outcomes in HIV+ kidney transplant recipients.

scholarly journals Metabolic Acidosis and Long-Term Clinical Outcomes in Kidney Transplant Recipients

2016 ◽  
Vol 28 (6) ◽  
pp. 1886-1897 ◽  
Author(s):  
Seokwoo Park ◽  
Eunjeong Kang ◽  
Sehoon Park ◽  
Yong Chul Kim ◽  
Seung Seok Han ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Clinical Outcomes ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
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