Donor oocyte‐facilitated reproduction: Time to revisit the BSH antenatal guidelines?

2020 ◽  
Vol 30 (6) ◽  
pp. 525-526
Author(s):  
John Quigley ◽  
Deirdre Sweetman ◽  
Cathy Allen ◽  
Mary F. Higgins ◽  
Carol Cantwell ◽  
...  
Keyword(s):  
Donor Oocyte

scholarly journals Prevalence of pathogenic copy number variants among children conceived by donor oocyte

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sandra Monfort ◽  
Carmen Orellana ◽  
Silvestre Oltra ◽  
Mónica Rosello ◽  
Alfonso Caro-Llopis ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Copy Number ◽  
Assisted Reproductive Technologies ◽  
Copy Number Variants ◽  
Reproductive Technologies ◽  
Significant Excess ◽  
Vitro Fertilization ◽  
Donor Oocyte ◽  
Increased Risk

AbstractDevelopment of assisted reproductive technologies to address infertility has favored the birth of many children in the last years. The majority of children born with these treatments are healthy, but some concerns remain on the safety of these medical procedures. We have retrospectively analyzed both the fertilization method and the microarray results in all those children born between 2010 and 2019 with multiple congenital anomalies, developmental delay and/or autistic spectrum disorder (n = 486) referred for array study in our center. This analysis showed a significant excess of pathogenic copy number variants among those patients conceived after in vitro fertilization with donor oocyte with respect to those patients conceived by natural fertilization (p = 0.0001). On the other hand, no significant excess of pathogenic copy number variants was observed among patients born by autologous oocyte in vitro fertilization. Further studies are necessary to confirm these results and in order to identify the factors that may contribute to an increased risk of genomic rearrangements, as well as consider the screening for genomic alterations after oocyte donation in prenatal diagnosis.

Estimating Frequency and Parental Origin of Embryo Aneuploidy: A Retrospective Analysis of Anonymous Donor Oocyte IVF Data

2015 ◽  
Vol 103 (2) ◽  
pp. e5-e6
Author(s):  
E.S. Sills ◽  
X. Li ◽  
J.L. Frederick ◽  
C.D. Khoury ◽  
D.A. Potter
Keyword(s):  
Retrospective Analysis ◽  
Parental Origin ◽  
Donor Oocyte

Origin of First Trimester 17 -Hydroxyprogesterone Levels as Determined in Pregnancies by Donor Oocyte Fertilization

1993 ◽  
Vol 36 (3) ◽  
pp. 136-140 ◽  
Author(s):  
J.H. Check ◽  
E.R. Barnea ◽  
D.B. Shapse ◽  
D. Lurie ◽  
C. Lurier ◽  
...  
Keyword(s):  
First Trimester ◽  
Donor Oocyte ◽  
Oocyte Fertilization ◽  
17 Hydroxyprogesterone

scholarly journals 920: Outcomes of pregnancies achieved by double gamete donation: a comparison with donor oocyte pregnancies

2017 ◽  
Vol 216 (1) ◽  
pp. S524-S525
Author(s):  
Lise Preaubert ◽  
Aurelie Vincent ◽  
Pietro Santulli ◽  
Vanessa Gayet ◽  
Francois Goffinet ◽  
...  
Keyword(s):  
Gamete Donation ◽  
Donor Oocyte

scholarly journals Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

2021 ◽  
Vol 22 (2) ◽  
pp. 551
Author(s):  
Luis Sendra ◽  
Alfredo García-Mares ◽  
María José Herrero ◽  
Salvador F. Aliño
Keyword(s):  
Mitochondrial Dna ◽  
Nuclear Dna ◽  
Genetic Disorders ◽  
Mitochondrial Diseases ◽  
Legal Regulation ◽  
Donor Oocyte ◽  
Legal Position ◽  
Ethical And Legal Issues ◽  
Mitochondrial Replacement Techniques ◽  
Do So

Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a poor prognosis and no known cure. The chance to have unaffected offspring with a genetic link is important for the affected families, and mitochondrial replacement techniques (MRTs) allow them to do so. MRTs consist of transferring the nuclear DNA from an oocyte with pathogenic mtDNA to an enucleated donor oocyte without pathogenic mtDNA. This paper aims to determine the efficacy, associated risks, and main ethical and legal issues related to MRTs. Methods: A bibliographic review was performed on the MEDLINE and Web of Science databases, along with searches for related clinical trials and news. Results: A total of 48 publications were included for review. Five MRT procedures were identified and their efficacy was compared. Three main risks associated with MRTs were discussed, and the ethical views and legal position of MRTs were reviewed. Conclusions: MRTs are an effective approach to minimizing the risk of transmitting mtDNA diseases, but they do not remove it entirely. Global legal regulation of MRTs is required.

scholarly journals Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles

2017 ◽  
Vol 108 (2) ◽  
pp. 262-268 ◽  
Author(s):  
Eduardo Hariton ◽  
Keewan Kim ◽  
Sunni L. Mumford ◽  
Marissa Palmor ◽  
Pietro Bortoletto ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Vitro Fertilization ◽  
Donor Oocyte

scholarly journals Do donor oocyte cycles comply with ASRM/SART embryo transfer guidelines? An analysis of 13,395 donor cycles from the SART registry

2015 ◽  
Vol 104 (3) ◽  
pp. e46
Author(s):  
K.S. Acharya ◽  
S. Keyhan ◽  
C.R. Acharya ◽  
J.S. Yeh ◽  
M. Provost ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Donor Oocyte
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