scholarly journals TDR INTERACTING PROTEIN 3 , encoding a PHD ‐finger transcription factor, regulates Ubisch bodies and pollen wall formation in rice

2019 ◽  
Vol 99 (5) ◽  
pp. 844-861 ◽  
Author(s):  
Zhengfu Yang ◽  
Lianping Sun ◽  
Peipei Zhang ◽  
Yingxin Zhang ◽  
Ping Yu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Pollen Wall ◽  
Interacting Protein ◽  
Phd Finger ◽  
Wall Formation ◽  
Ubisch Bodies

scholarly journals TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH2-terminal kinase and transcription factor AP-1

FEBS Letters ◽  
2006 ◽  
Vol 580 (19) ◽  
pp. 4591-4596 ◽  
Author(s):  
Surinder M. Soond ◽  
Jennifer L. Terry ◽  
David W.H. Riches
Keyword(s):  
Transcription Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Interacting Protein ◽  
Necrosis Factor

scholarly journals Regulation of expression of the p21CIP1 gene by the transcription factor ZNF217 and MDM2

2016 ◽  
Vol 94 (6) ◽  
pp. 560-568
Author(s):  
Aglaia Mantsou ◽  
Evangelia Koutsogiannouli ◽  
Costas Haitoglou ◽  
Athanasios G. Papavassiliou ◽  
Nikolaos A. Papanikolaou
Keyword(s):  
Transcription Factor ◽  
Direct Interaction ◽  
In Silico Analysis ◽  
Protein Product ◽  
Regulation Of Expression ◽  
Interacting Protein ◽  
Promoter Construct ◽  
Specific Affinity ◽  
Steady State Levels ◽  
P21 Promoter

Using mouse double minute 2 (MDM2) protein-specific affinity chromatography and mass spectrometry, we have isolated the protein product of the oncogene znf217, which is a transcription factor and a component of a Hela-S-derived HDAC1 complex, as a novel MDM2-interacting protein. When co-expressed in cultured cancer cells, ZNF217 forms a complex with MDM2 and its ectopic over-expression reduces the steady-state levels of acetylated p53 in cell lines, suppressing its ability to activate the expression of a p21 promoter construct. In-silico analysis of the p21 promoter revealed the presence of several ZNF217-binding sites. These findings suggest that MDM2 controls p21 expression by at least 2 mechanisms: through ZNF217-mediated recruitment of HDAC1/MDM2 activity, which inhibits p53 acetylation; and through direct interaction with its binding site(s) on the p21 promoter.

IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion

2019 ◽  
Vol 12 (593) ◽  
pp. eaav7666 ◽  
Author(s):  
Chen-Yeh Ke ◽  
Hua-Hsuan Mei ◽  
Fen-Hwa Wong ◽  
Lun-Jou Lo
Keyword(s):  
Transcription Factor ◽  
Cell Apoptosis ◽  
Transforming Growth Factor ◽  
Kinase Inhibitor ◽  
Ex Vivo ◽  
Human Cancer ◽  
Ectopic Expression ◽  
Interacting Protein ◽  
Human Cancer Cells

Cleft palate is a common craniofacial defect caused by a failure in palate fusion. The palatal shelves migrate toward one another and meet at the embryonic midline, creating a seam. Transforming growth factor–β3 (TGF-β3)–induced apoptosis of the medial edge epithelium (MEE), the cells located along the seam, is required for completion of palate fusion. The transcription factor interferon regulatory factor 6 (IRF6) promotes TGF-β3–induced MEE cell apoptosis by stimulating the degradation of the transcription factor ΔNp63 and promoting the expression of the gene encoding the cyclin-dependent kinase inhibitor p21. Because homeodomain-interacting protein kinase 2 (HIPK2) functions downstream of IRF6 in human cancer cells and is required for ΔNp63 protein degradation in keratinocytes, we investigated whether HIPK2 played a role in IRF6-induced ΔNp63 degradation in palate fusion. HIPK2 was present in the MEE cells of mouse palatal shelves during seam formation in vivo, and ectopic expression of IRF6 in palatal shelves cultured ex vivo stimulated the expression of Hipk2 and the accumulation of phosphorylated HIPK2. Knockdown and ectopic expression experiments in organ culture demonstrated that p21 was required for HIPK2- and IRF6-dependent activation of caspase 3, MEE apoptosis, and palate fusion. Contact between palatal shelves enhanced the phosphorylation of TGF-β–activated kinase 1 (TAK1), which promoted the phosphorylation of HIPK2 and palate fusion. Our findings demonstrate that HIPK2 promotes seam cell apoptosis and palate fusion downstream of IRF6 and that IRF6 and TAK1 appear to coordinately enhance the abundance and activation of HIPK2 during palate fusion.

scholarly journals Transporters involved in pH and K+ homeostasis affect pollen wall formation, male fertility, and embryo development

2017 ◽  
Vol 68 (12) ◽  
pp. 3165-3178 ◽  
Author(s):  
Senthilkumar Padmanaban ◽  
Daniel D Czerny ◽  
Kara A Levin ◽  
Alexander R Leydon ◽  
Robert T Su ◽  
...  
Keyword(s):  
Embryo Development ◽  
Male Fertility ◽  
Pollen Wall ◽  
Wall Formation

scholarly journals A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9289 ◽  
Author(s):  
Etsuko Miyamoto-Sato ◽  
Shigeo Fujimori ◽  
Masamichi Ishizaka ◽  
Naoya Hirai ◽  
Kazuyo Masuoka ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Interacting Protein ◽  
Transcription Factor Networks ◽  
Human Transcription Factor

scholarly journals The Groucho-associated Phosphatase PPM1B Displaces Pax Transactivation Domain Interacting Protein (PTIP) to Switch the Transcription Factor Pax2 from a Transcriptional Activator to a Repressor

2015 ◽  
Vol 290 (11) ◽  
pp. 7185-7194 ◽  
Author(s):  
Saji Abraham ◽  
Raghavendra Paknikar ◽  
Samina Bhumbra ◽  
Danny Luan ◽  
Rohan Garg ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcriptional Activator ◽  
Transactivation Domain ◽  
Interacting Protein

scholarly journals Rice GLYCOSYLTRANSFERASE1 Encodes a Glycosyltransferase Essential for Pollen Wall Formation

2012 ◽  
Vol 161 (2) ◽  
pp. 663-675 ◽  
Author(s):  
Sunok Moon ◽  
Sung-Ryul Kim ◽  
Guochao Zhao ◽  
Jakyung Yi ◽  
Youngchul Yoo ◽  
...  
Keyword(s):  
Pollen Wall ◽  
Wall Formation

scholarly journals Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

2001 ◽  
Vol 276 (24) ◽  
pp. 20858-20865 ◽  
Author(s):  
Chuan Hua He ◽  
Pengfei Gong ◽  
Bin Hu ◽  
Daniel Stewart ◽  
Mary E. Choi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Interacting Protein ◽  
Activating Transcription Factor 4 ◽  
Activating Transcription Factor ◽  
Transcription Factor 4
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