Transfusion and hematologic variables after fibrinogen or platelet transfusion in valve replacement surgery: preliminary data of purified lyophilized human fibrinogen concentrate versus conventional transfusion

Transfusion ◽  
2013 ◽  
Vol 54 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Kenichi A. Tanaka ◽  
Katherine Egan ◽  
Fania Szlam ◽  
Satoru Ogawa ◽  
John D. Roback ◽  
...  
Keyword(s):  
Valve Replacement ◽  
Preliminary Data ◽  
Platelet Transfusion ◽  
Fibrinogen Concentrate ◽  
Human Fibrinogen ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

scholarly journals The Efficacy and Safety of Postoperative Tranexamic Acid, Hemocoagulase Agkistrodon, and their Combination in Patients Undergoing Heart Valve Replacement With Cardiopulmonary Bypass

2021 ◽  
Author(s):  
Jingxiu Chen ◽  
Jingjie Li ◽  
Jiajia Yan ◽  
Qiuyi He ◽  
Min Huang ◽  
...  
Keyword(s):  
Blood Loss ◽  
Valve Replacement ◽  
Blood Cells ◽  
Postoperative Blood Loss ◽  
Thromboembolic Events ◽  
Efficacy And Safety ◽  
Human Fibrinogen ◽  
Pericardial Drainage ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

Abstract Background Excessive bleeding is a major complication in patients undergoing cardiac surgery. We aimed to compare the efficacy and safety of postoperative tranexamic acid (TXA), hemocoagulase agkistrodon and their combination in patients undergoing heart valve replacement surgery with cardiopulmonary bypass (CPB). Methods This was a retrospective study. The enrolled patients were intravenously injected with TXA at a dose of 1.0 g during the intraoperative period. After surgery, the patients were assigned to four groups: the control group (Group C), the TXA group (Group T), the hemocoagulase agkistrodon group (Group H) and the combination group (Group TH). The primary efficacy outcomes were the total blood loss (TBL) from the time of the operation to postoperative Day 2, postoperative blood loss within 2 days, and transfusion of red blood cells and plasma from the operation to postoperative Day 3. The primary safety endpoint was the incidence of thromboembolic events. Results A total of 252 patients were recruited. There were no statistically significant differences in terms of the TBL, postoperative blood loss, volumes of red blood cells or plasma transfusion among the four groups. However, an increased total pericardial drainage volume and longer length of stay in the ICU were found in Group H compared with in Group T. In addition, increased volumes of total pericardial drainage were found in Group TH compared with Groups C and T. A similar result was also found in the number of days of pericardial drainage. Regarding safety outcomes, fibrinogen levels on postoperative Days 1 and 2 in Groups H and TH were significantly lower than those in Groups C and T, while the frequencies of human fibrinogen transfusion in Groups H and TH were higher, with the highest frequency in Group H. The transfusions of human fibrinogen among Groups C, T, H and TH were 1.45%, 2.78%, 64.71%, and 28.72%, respectively. No significant differences were found in the postoperative incidences of thromboembolic events and acute kidney injuries among all groups. Conclusions Bleeding events after cardiac valve replacement surgery with CPB were not improved by postoperative administration of TXA, hemocoagulase agkistrodon or their combination. Hemocoagulase agkistrodon is related to hypofibrinogenemia and increased transfusions of human fibrinogen.

588 Determinants of left ventricular mass regression after aortic valve replacement surgery on aortic stenosis

1999 ◽  
Vol 1 ◽  
pp. S96-S96
Author(s):  
L COELHO ◽  
A SALGADO ◽  
J MALDONADO ◽  
M COSTA ◽  
R PIRES ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Aortic Valve Replacement ◽  
Left Ventricular Mass ◽  
Valve Replacement ◽  
Left Ventricular ◽  
Replacement Surgery ◽  
Ventricular Mass ◽  
Valve Replacement Surgery

Myocardial Potassium and Lactate Balance during Valve-Replacement Surgery

Circulation ◽  
1969 ◽  
Vol 39 (5s1) ◽  
Author(s):  
COLIN W. MCCORD ◽  
RICHARD S. CRAMPTON ◽  
MICHEL G. NASSER ◽  
ROBERT B. CASE ◽  
Anna Maria Wachter
Keyword(s):  
Valve Replacement ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

Outcomes after Mitral and Aortic Valve Replacement Surgery: Comparison and Predictors

2011 ◽  
Vol 20 (1) ◽  
pp. 53
Author(s):  
Mahmoon Shirzad ◽  
Abbasali Karimi ◽  
Seyed Hossein Ahmadi ◽  
Samaneh Dowlatshahi ◽  
Saeed Davoodi ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

RELATIONSHIP OF PREOPERATIVE RIGHT VENTRICULAR FUNCTION AND OUTCOME AFTER MITRAL VALVE REPLACEMENT SURGERY – A PROSPECTIVE OBSERVATIONAL STUDY

2020 ◽  
pp. 43-46
Author(s):  
Debashis Karmokar ◽  
Pinaki Majumdar ◽  
Manjushree Ray ◽  
Asim Kumar Kundu
Keyword(s):  
Mitral Valve ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Right Ventricular Function ◽  
Low Cardiac Output Syndrome ◽  
Replacement Surgery ◽  
Grade 3 ◽  
Valve Replacement Surgery

Objective:Right ventricular dysfunction constitutes a major risk factor for patients suffering from degenerative mitral valve disease. The objective of this study was to assess right ventricular function by echocardiography and to detect role of right ventricular functions in prediction of outcome following mitral valve replacement operation in patients with rheumatic heart disease involving mitral valve. Methods:Transthoracic 3D echocardiography was done in 52 patients posted for mitral valve replacement surgery. Right ventricular function was analyzed by measuring fractional area change (FAC) of right ventricle, tethering distance and, tricuspid annular plane systolic excursion (TAPSE). Tricuspid regurgitation was graded 0 to 4. Based on echocardiographic ndings of right ventricle, patients were allocated in two groups; Group A (normal right ventricular function) and Group B (poor right ventricular function). After surgery, incidence of complications such as; low cardiac output syndrome, refractory arrhythmia and, sepsis were compared in two group. Results: Incidence of postoperative complication such as low cardiac output syndrome and sepsis was signicantly more in patients with poor right ventricular function. Right ventricular variables, FAC <35%, TAPSE <17 mm and tethering distance > 8 mm are independent predictors of postoperative complications. Tricuspid valve was repaired in patients with grade 3 and 4 regurgitation. Therefore cardiopulmonary bypass time was signicantly more in patients with grade 3 and 4 TR (84.42±69.77 min) (p<0.01). Duration of intensive care support was also signicantly more in patients with poor right ventricular function (p<0.001) Conclusion: To predict possible complications and outcome following mitral valve replacement surgery, right ventricular functions should be thoroughly assessed by 3D echocardiography

CE TEST: Endocarditis After Valve Replacement Surgery

2006 ◽  
Vol 106 (2) ◽  
pp. 51-52
Author(s):  
&NA;
Keyword(s):  
Valve Replacement ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

Postconditioning the Human Heart with Adenosine in Heart Valve Replacement Surgery

2007 ◽  
Vol 83 (6) ◽  
pp. 2066-2072 ◽  
Author(s):  
Zhen-Xiao Jin ◽  
Jing-Jun Zhou ◽  
Mei Xin ◽  
Dao-Rong Peng ◽  
Xi-Ming Wang ◽  
...  
Keyword(s):  
Valve Replacement ◽  
Heart Valve ◽  
Human Heart ◽  
Heart Valve Replacement ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

Giant Left Ventricular Pseudoaneurysm as a Complication After Mitral Valve Replacement Surgery

2014 ◽  
Vol 98 (4) ◽  
pp. 1480 ◽  
Author(s):  
Stefan Baumann ◽  
Matthias Renker ◽  
James V. Spearman ◽  
Richard R. Bayer ◽  
U. Joseph Schoepf ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Left Ventricular ◽  
Left Ventricular Pseudoaneurysm ◽  
Replacement Surgery ◽  
Valve Replacement Surgery
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