Blood donor screening in the Netherlands: Universal anti‐HBc screening in combination with HBV nucleic acid amplification testing may allow discontinuation of hepatitis B virus antigen testing

Transfusion ◽  
2021 ◽  
Author(s):  
Thijs J. Laar ◽  
Boris M. Hogema ◽  
Marijke W. Molenaar‐de Backer ◽  
Tanneke Marijt‐van der Kreek ◽  
Hans L. Zaaijer









2005 ◽  
Vol 86 (3) ◽  
pp. 595-599 ◽  
Author(s):  
Hitoshi Ohnuma ◽  
Akira Yoshikawa ◽  
Hideaki Mizoguchi ◽  
Hiroaki Okamoto ◽  

The Japanese Red Cross has been conducting a nucleic acid amplification test (NAT) screening for hepatitis B virus (HBV), hepatitis C virus and human immunodeficiency virus 1 among blood donors since July 1 1999. The first case of HBV genotype H was found and reported in Japan. Serological markers of HBV were not detected in this NAT-positive donation. It may be that the positive donation was in the serological window period at the early stage of infection. The complete genome of 3215 nt was sequenced, and the sequence had 99·3 % homology with the strain from Los Angeles, USA (LSA2523). Here, a leucine zipper motif was found in the region of the HBV surface antigen conserved through genotypes A–H.



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