Ultra-short echo-time magnetic resonance imaging distinguishes ischemia/reperfusion injury from acute rejection in a mouse lung transplantation model

Fibrosis is often heterogeneously distributed, and classical biopsies do not reflect this. Noninvasive methods for renal fibrosis have been developed to follow chronic kidney diseases (CKD) and to monitor anti-fibrotic therapy. In this study, we combined two approaches to assess fibrosis regression following renal ischemia-reperfusion injury (IRI): magnetic resonance imaging (MRI) and noninvasive extracellular matrix (ECM) biomarkers. MRI was used to evaluate fibrosis in bilateral IRI in rats after reperfusion at 7, 14, and 21 days. This was performed with 1HT1 and T2* mapping, dynamic contrast-enhanced (DCE)-MRI, and chemical shift imaging (CSI)-23Na. The degradation of laminin gamma-1 chain (LG1M) and type III collagen (C3M) was measured in urine and plasma. Fibrosis was analyzed in tissue using fibronectin (FN) and alpha-smooth muscle actin (α-SMA) using quantitative polymerase chain reaction qPCR and western blotting. We found increased fibrosis 7 days after reperfusion, which dropped to sham levels after 21 days. Single kidney glomerular filtration rate (skGFR), perfusion (DCE-MRI), and total 23Na kidney content correlated positively with fibrotic markers FN and α-SMA as well as noninvasive LG1M and C3M. We showed that novel MRI protocols and ECM markers could track fibrogenic development. This could give rise to a multi-parametric practice to diagnose and assess fibrosis whilst treating kidney disease without using invasive methods.

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Short Echo Time Magnetic Resonance Imaging of Tendon

Investigative Radiology ◽

10.1097/00004424-199312000-00003 ◽

1993 ◽

Vol 28 (12) ◽

pp. 1095-1100 ◽

Cited By ~ 29

Author(s):

PHILIP D. KOBLIK ◽

DOMINIQUE M. FREEMAN

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Echo Time ◽

Short Echo Time

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Use of Short Echo Time Two-Dimensional 1H-Magnetic Resonance Spectroscopy in Temporal Lobe Epilepsy with Negative Magnetic Resonance Imaging Findings

Journal of International Medical Research ◽

10.1177/147323000903700428 ◽

2009 ◽

Vol 37 (4) ◽

pp. 1211-1219 ◽

Cited By ~ 2

Author(s):

J Shen ◽

L Zhang ◽

X Tian ◽

J Liu ◽

X Ge ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Resonance Spectroscopy ◽

Healthy Controls ◽

Two Dimensional ◽

Resonance Imaging ◽

Mri Findings ◽

Echo Time ◽

Short Echo Time ◽

Negative Magnetic Resonance Imaging

We evaluated short echo time two-dimensional 1H magnetic resonance spectroscopy (2D-1HMRS) with the point-resolved spatial selection (PRESS) protocol in temporal lobe epilepsy (TLE) patients with negative magnetic resonance imaging (MRI) findings and described the characteristics of 2D-1HMRS in the epileptic focus. Thirty-eight TLE patients with negative conventional MRI findings and 10 healthy controls were studied by 2D-1HMRS. A 128-channel prolonged video-electroencephalographic (EEG) method was used as the standard for epileptogenic focus localization to evaluate N-acetyl aspartate/(choline + creatine + phospho - creatine) (NAA/[Cho + Cr–PCr]), glutamate + glutamine/creatine (Glx/Cr–PCr) and myo-inositol/Cr–PCr ratios in patients with negative MRI findings. The 2D-1HMRS showed that 32/38 patients and all healthy controls had stable baselines and good signal-to-noise ratios. Compared with the healthy controls, 32 patients showed abnormal NAA/(Cho + Cr–PCr) ratios in the hippocampus and, in 25 of these patients, focus lateralization agreed with the EEG. It is concluded that short echo time 2D-1HMRS with the PRESS protocol can help find abnormalities in lateralization of temporal epilepsy in patients with negative MRI findings.

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Ultra-short echo time magnetic resonance imaging for detection of pulmonary arteriovenous malformation recanalization after coil embolization: a case report and a phantom study

Acta Radiologica Open ◽

10.1177/2058460117732101 ◽

2017 ◽

Vol 6 (9) ◽

pp. 205846011773210 ◽

Cited By ~ 2

Author(s):

Kohei Hamamoto ◽

Emiko Chiba ◽

Katsuhiko Matsuura ◽

Tomohisa Okochi ◽

Keisuke Tanno ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Arteriovenous Malformation ◽

Pulmonary Arteries ◽

Transcatheter Embolization ◽

Phantom Study ◽

Pulmonary Arteriovenous Malformation ◽

Resonance Imaging ◽

Echo Time ◽

Short Echo Time

A pulmonary arteriovenous malformation (PAVM) is a direct connection between the pulmonary arteries and veins for which metallic coil transcatheter embolization is the standard of care. Detecting recanalization after PAVM treatment is crucial, but direct visualization with computed tomography or magnetic resonance imaging (MRI) is generally difficult. Here, we report a case of a recanalized PAVM that was directly detected with ultra-short echo time MRI. The detection of these signals in the coils was confirmed in a phantom study.

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