Randomized, double-blinded, placebo-controlled pilot study on the effects of topical blackcurrant emulsion enriched in essential fatty acids, ceramides and 18-beta glycyrrhetinic acid on clinical signs and skin barrier function in dogs with atopic dermati

2017 ◽  
Vol 28 (6) ◽  
pp. 577-e140 ◽  
Author(s):  
Rosanna Marsella ◽  
Luisa Cornegliani ◽  
Ibrahim Ozmen ◽  
Mary Bohannon ◽  
Kim Ahrens ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pilot Study ◽  
Barrier Function ◽  
Essential Fatty Acids ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Glycyrrhetinic Acid ◽  
Skin Barrier Function ◽  
Double Blinded

scholarly journals Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis

2021 ◽  
Vol 8 ◽  
Author(s):  
Ju-Yong Park ◽  
Seon-Myeong Kim ◽  
Jung-Hyun Kim
Keyword(s):  
Atopic Dermatitis ◽  
Relative Abundance ◽  
Barrier Function ◽  
Therapeutic Option ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Canine Atopic Dermatitis ◽  
Allergic Skin

The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.

16437 Effects of cleansing on skin barrier function in atopic dermatitis and healthy skin: A pilot study

2020 ◽  
Vol 83 (6) ◽  
pp. AB63
Author(s):  
Aleksi J. Hendricks ◽  
Bryan W. Kromenacker ◽  
Alyssa Thompson ◽  
Elizabeth I. Mata ◽  
Catherine M. Ludwig ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Healthy Skin

scholarly journals Evaluation of the effect of a 0.0584% hydrocortisone aceponate spray on clinical signs and skin barrier function in dogs with atopic dermatitis

2012 ◽  
Vol 13 (2) ◽  
pp. 187 ◽  
Author(s):  
Eui-Hwa Nam ◽  
Seol-Hee Park ◽  
Ji-Young Jung ◽  
Seung-Hee Han ◽  
Hwa-Young Youn ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function

scholarly journals Effect of Alkyl Structure (Straight Chain/Branched Chain/Unsaturation) of C18 Fatty Acid Sodium Soap on Skin Barrier Function

2020 ◽  
Vol 10 (12) ◽  
pp. 4310
Author(s):  
Koji Kubota ◽  
Akie Kakishita ◽  
Mana Okasaka ◽  
Yuka Tokunaga ◽  
Sadaki Takata
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Barrier Function ◽  
Anionic Surfactants ◽  
Skin Barrier ◽  
Fatty Acid Soap ◽  
Skin Tissue ◽  
Acid Soap ◽  
Skin Barrier Function ◽  
Transmission Index

Anionic surfactants are commonly used as detergents and emulsifiers. However, these compounds are potent skin irritants. In this study, we evaluated the effect of the alkyl structure of anionic surfactants on the skin barrier function using the transmission index (TI) method. The TI method is used to measure the skin penetration rate of drugs. Sodium soaps of C18 fatty acids with different structures were evaluated. Sodium laurate was used as the control. In addition, microscopic observations of the skin tissue treated with different soaps and controls were performed to study the mechanism of skin permeation. Results showed that unsaturated fatty acid soaps exerted the most potent effect on the skin barrier function and saturated fatty acid soaps exerted the least effect; saturated branched fatty acid soap had an intermediate effect. This could be attributed to the differences in the melting points of different fatty acids. In addition, unlike lauric acid soap, C18 fatty acid soap did not cause morphological changes in the skin tissue. Thus, differences in the alkyl structure of fatty acids resulted in differences in the effect of fatty acid soaps on the skin barrier function. The mechanism was presumed to be an effect on intercellular lipids.

Randomized Controlled Pilot Study of Dietary Supplementation with Turmeric or Herbal Combination Tablets on Skin Barrier Function in Healthy Subjects

2018 ◽  
Vol 21 (12) ◽  
pp. 1260-1265
Author(s):  
Alexandra R. Vaughn ◽  
Ashley K. Clark ◽  
Manisha Notay ◽  
Raja K. Sivamani
Keyword(s):  
Pilot Study ◽  
Barrier Function ◽  
Healthy Subjects ◽  
Skin Barrier ◽  
Dietary Supplementation ◽  
Skin Barrier Function ◽  
Randomized Controlled

Pilot study using five methods to evaluate skin barrier function in healthy dogs and in dogs with atopic dermatitis

2019 ◽  
Vol 30 (2) ◽  
pp. 121-e34 ◽  
Author(s):  
Danielle Cobiella ◽  
Linda Archer ◽  
Mary Bohannon ◽  
Domenico Santoro
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Healthy Dogs

scholarly journals ALLERGIC MANIFESTATIONS OF PRIMARY IMMUNODEFICIENCY DISEASES AND ITS TREATMENT APPROACHES

2018 ◽  
Vol 11 (11) ◽  
pp. 83
Author(s):  
Oksana Boyarchuk
Keyword(s):  
Primary Immunodeficiency ◽  
Barrier Function ◽  
Clinical Signs ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Primary Immunodeficiency Diseases ◽  
Treatment Approaches ◽  
Netherton Syndrome ◽  
Immunodeficiency Diseases ◽  
Allergic Manifestations

Allergic manifestations are one of the clinical signs of primary immunodeficiency diseases (PID). In this review, the common allergic manifestations of PID are summarized, and their main differential characteristics and treatment approaches are outlined. Allergic manifestations occur more often in patients with combined immunodeficiencies with or without associated or syndromic features. In patients with PID they usually are present in the 1st year of life, may be among the first symptoms of PID, and are commonly manifested by eczema and increased immunoglobulin (Ig)-G levels. Often the skin barrier function is not impaired in patients with eczema and PID, although some diseases (such as Comel-Netherton syndrome) do affect skin barrier function. There is usually no correlation between IgE levels and the severity of allergic skin manifestations. Allergic-like manifestations in PID patients include urticaria-like rash and angioedema. Urticaria-like rash is associated with autoinflammatory disorders, which are commonly accompanied by fever, and caused by a neutrophilic infiltrate in the dermis. Angioedema in hereditary angioedema patients is caused by high bradykinin production. Early differentiation of allergic manifestations in PID from atopic dermatitis and other atopic conditions is very difficult; however, it is very important because it influences on treatment methods. A multidisciplinary approach to the management of PID patients, with the involvement of immunologists, allergists, and formulation of appropriate treatment improve the prognosis and quality of life of the PID patients.

Influence of sunflower seed oil or baby lotion on the skin barrier function of newborns: A pilot study

2017 ◽  
Vol 16 (4) ◽  
pp. 500-507 ◽  
Author(s):  
Varvara Kanti ◽  
Malise Günther ◽  
Andrea Stroux ◽  
Sabine Sawatzky ◽  
Wolfgang Henrich ◽  
...  
Keyword(s):  
Pilot Study ◽  
Barrier Function ◽  
Sunflower Seed ◽  
Seed Oil ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Sunflower Seed Oil
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