scholarly journals Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil

2018 ◽  
Vol 14 (3) ◽  
pp. 360-363
Author(s):  
Tri Ujilestari ◽  
Nanung Danar Dono ◽  
Bambang Ariyadi ◽  
Ronny Martien ◽  
Zuprizal Zuprizal
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Drug Delivery Systems ◽  
Coconut Oil ◽  
Tween 80 ◽  
Delivery Systems ◽  
Feed Additive ◽  
Spherical Droplet ◽  
Droplet Morphology ◽  
Lemongrass Essential Oil

The present research was aimed to characterize the formula of self-nano emulsifying drug delivery systems (SNEDDS) for lemongrass essential oil. The observation variables included: particle size, zeta potential, and morphology. Meanwhile, the materials consisted of the mixtures of oils (lemongrass essential oil and carrier oil), surfactants, and cosurfactants. Carrier oils were screened as candidates for SNEDDS, and the formula was evaluated for transmittance and emulsification time. The value of the formulation component was lemongrass essential oils, carrier oil (Virgin Coconut Oil), surfactant (Tween 80), and co-surfactant (PEG 400) = 8.34, 8.34, 71.43, and 16.67 % respectively. The formulation had a mean of the nanoemulsion droplet diameters of 20.7 nm with the polydispersity index (PI) 0.378 and potential zeta -73 mV. The transmission electron microscopy demonstrated spherical droplet morphology. This research produced SNEDDS of lemongrass essential oil with nanoparticle size that can be used as feed additive for poultry

scholarly journals OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF LEMONGRASS (CYMBOPOGON CITRATUS) ESSENTIAL OIL

2019 ◽  
Vol 11 (1) ◽  
pp. 144
Author(s):  
Tri Ujilestari ◽  
Bambang Ariyadi ◽  
Ronny Martien ◽  
Zuprizal . ◽  
Nanung Danar Dono
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Coconut Oil ◽  
Tween 80 ◽  
Cymbopogon Citratus ◽  
Peg 400 ◽  
Transmission Electron ◽  
Poorly Soluble ◽  
Optimum Formula ◽  
Mixture Experimental Design

Objective: Focus of this study was to optimize and to characterize the self-Nano emulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17±0.06 nm, 0.17±0.05,-20.90±1.47 mV, 200±0mPa. s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test; meanwhile, transmission electron microscopy displayed spherical shape.Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.

scholarly journals Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Nicholas C. Obitte ◽  
Kenneth C. Ofokansi ◽  
Franklin C. Kenechukwu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Tween 80 ◽  
Delivery Systems ◽  
Inflammatory Activity ◽  
Capra Hircus ◽  
Anti Inflammatory

In this study, goat fat (Capra hircus) and melon oil were extracted and used to formulate self-nanoemulsifying drug delivery systems (SNEDDS) based on either goat fat alone or its admixture with melon oil by employing escalating ratios of oil(s), surfactant blend (1 : 1 Tween 60 and Tween 80), and cosurfactant (Span 85), with or without carbosil, a glidant, for the delivery of indomethacin. The formulations were encapsulated in hard gelatin capsules and then assessed using isotropicity test, aqueous dilution stability and precipitation propensity, absolute drug content, emulsification time, in vitro drug release, and anti-inflammatory activity. The SNEDDS exhibited low precipitation propensity and excellent stability on copious dilution, as well as high drug release in vitro and in vivo. The inhibition produced by the SNEDDS was comparable to that of indomethacin injection (positive control) for much of the 5 h test period, indicating a high degree of bioavailability of the administered SNEDDS. The absolute drug contents and emulsification times fell within narrow limits. This study has shown that a 1 : 1 ratio of melon oil and goat fat could confer favourable properties with respect to drug release and anti-inflammatory activity on SNEDDS for the delivery of indomethacin, thus encouraging further development of the formulations.

scholarly journals Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Pankajkumar S. Yadav ◽  
Ekta Yadav ◽  
Amita Verma ◽  
Saima Amin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tween 80 ◽  
Delivery Systems ◽  
Dissolution Profile ◽  
Rate Of Dissolution ◽  
Capmul Mcm

The objective of the current work was to develop optimized self-nanoemulsifying drug delivery systems (SNEDDS) and evaluate theirin vitroandin vivoperformance. The research comprised various studies which includes solubility studies in various vehicles, pseudoternary phase diagram construction, and preparation and characterization of SNEDDS along within vitrodissolution andin vivopharmacodynamic profiling. Based on dissolution profile, a remarkable increase in rate of dissolution was observed in comparison with plain drug and marketed formulation. Optimized SNEDDS formulation was composed of Capmul MCM (19.17% w/w), Tween 80 (57.5% w/w), Transcutol P (12.7% w/w), and HCT (4.17% w/w).In vivopharmacodynamic evaluation in Wistar rats showed considerable increase in pharmacological effect of HCT by SNEDDS formulation as compared with plain HCT.

scholarly journals New Approach for Administration of Doxazosin Mesylate: Comparative Study between Liquid and Solid Self-nanoemulsifying Drug Delivery Systems

2021 ◽  
Vol 12 (2) ◽  
pp. 1095-1101
Author(s):  
Al Zahraa G. Al Ashmawy ◽  
Noura G. Eissa ◽  
Gehan F. Balata ◽  
Hanan M. El Nahas
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Tween 80 ◽  
Delivery Systems ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Surfactant Mixture ◽  
Doxazosin Mesylate

Self-nanoemulsifying drug delivery systems (SNEDDS) in both liquid and solid forms were suggested to improve water solubility of Doxazosin mesylate (DOX) a poorly water- soluble antihypertensive drug. Oleic acid: Smix (1:9 w/w) and Tween 80: co-surfactant mixture (Ethanol and PEG 400) (1:1, 2:1, 3:1 and 4:1) were chosen to prepare a liquid and solid forms of SNEDDS according to their solubility. TEM images revealed change in the  crystalline nature of DOX into uniform particles with smooth surface. Characterization studies revealed droplet size ranges from  79.80±14.39 to 273.10±4.17 nm, zeta potential ranges from -5.57±0.10 to -21.13±0.46 mV and dissolution enhancement of more than two folds with more favorable properties for the solid forms. FTIR demonstrated significant physical changes in DOX crystalline structure. In conclusion, the solid SNEDDS containing oleic acid: Smix (1:9 w/w) and Tween 80: co-surfactant mixture (3:1 w/w) and adsorbent mixture of Avicel 101 and Aerosil 200 (40:1 w/w) might be a promising formula for better management of hypertension with expected shelf stability.

Polyacrylonitrile/Syzygium aromaticum hierarchical hydrophilic nanocomposite as a carrier for antibacterial drug delivery systems

RSC Advances ◽  
2015 ◽  
Vol 5 (5) ◽  
pp. 3291-3298 ◽  
Author(s):  
Ramdayal Yadav ◽  
K. Balasubramanian
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Electrospinning Process ◽  
Antibacterial Drug ◽  
Syzygium Aromaticum

A versatile, maneuverable electrospinning process was exploited to fabricate intertwined-heterostructure polyacrylonitrile (PAN) nanofibers by incorporating the essential oilSyzygium aromaticumfor antibacterial drug delivery systems.

Therapeutic Potential of Melaleuca alternifolia Essential Oil in New Drug Delivery Systems

2020 ◽  
Vol 26 (33) ◽  
pp. 4048-4055 ◽  
Author(s):  
Karoll M. A. de Assis ◽  
Renaly I. de A. Rêgo ◽  
Demis F. de Melo ◽  
Laryssa M. da Silva ◽  
João A. Oshiro- Júnior ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Delivery Systems ◽  
Tea Tree ◽  
New Drug ◽  
Anti Inflammatory ◽  
Therapeutic Alternatives

Medicinal plants produce secondary metabolites with special biological activities, which may be used as new therapeutic alternatives. For instance, tea tree essential oil (TTO) was shown to exert antimicrobial, antifungal, anthelmintic, antiviral, anti-tumor and anti-inflammatory activities. Due to their thermal instability, active principles can be easily degraded by physicochemical processes; therefore, they must be protected to increase their time of action and improve their controlled release. The aim of this review is to discuss formulations incorporating encapsulated TTO as the active ingredient. Micro and nanoencapsulated systems proved to be more thermostable than TTO and to exert better antimicrobial, antifungal, antiparasitic and larvicidal effects. Nanoencapsulation also reduced oil toxicity. Emulsified and hybrid systems developed by various methods showed improved repellent, antibacterial, antifungal and anti-inflammatory activities, thereby proving promising for the pharmaceutical industry. Liposomal formulations produced by hydration of lipid films exhibited constant rate of terpinen-4-ol release. In addition, their incorporation into biomaterials, such as sponges, nanofibers and films, showed great potential for treating infections. Mainly due to the advantages of their incorporation into new drug delivery systems over conventional formulations, there is an interest in the development of systems containing TTO as a pharmaceutical ingredient of plant origin.

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