scholarly journals OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF LEMONGRASS (CYMBOPOGON CITRATUS) ESSENTIAL OIL

2019 ◽  
Vol 11 (1) ◽  
pp. 144
Author(s):  
Tri Ujilestari ◽  
Bambang Ariyadi ◽  
Ronny Martien ◽  
Zuprizal . ◽  
Nanung Danar Dono
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Coconut Oil ◽  
Tween 80 ◽  
Cymbopogon Citratus ◽  
Peg 400 ◽  
Transmission Electron ◽  
Poorly Soluble ◽  
Optimum Formula ◽  
Mixture Experimental Design

Objective: Focus of this study was to optimize and to characterize the self-Nano emulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17±0.06 nm, 0.17±0.05,-20.90±1.47 mV, 200±0mPa. s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test; meanwhile, transmission electron microscopy displayed spherical shape.Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.

scholarly journals Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil

2018 ◽  
Vol 14 (3) ◽  
pp. 360-363
Author(s):  
Tri Ujilestari ◽  
Nanung Danar Dono ◽  
Bambang Ariyadi ◽  
Ronny Martien ◽  
Zuprizal Zuprizal
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Drug Delivery Systems ◽  
Coconut Oil ◽  
Tween 80 ◽  
Delivery Systems ◽  
Feed Additive ◽  
Spherical Droplet ◽  
Droplet Morphology ◽  
Lemongrass Essential Oil

The present research was aimed to characterize the formula of self-nano emulsifying drug delivery systems (SNEDDS) for lemongrass essential oil. The observation variables included: particle size, zeta potential, and morphology. Meanwhile, the materials consisted of the mixtures of oils (lemongrass essential oil and carrier oil), surfactants, and cosurfactants. Carrier oils were screened as candidates for SNEDDS, and the formula was evaluated for transmittance and emulsification time. The value of the formulation component was lemongrass essential oils, carrier oil (Virgin Coconut Oil), surfactant (Tween 80), and co-surfactant (PEG 400) = 8.34, 8.34, 71.43, and 16.67 % respectively. The formulation had a mean of the nanoemulsion droplet diameters of 20.7 nm with the polydispersity index (PI) 0.378 and potential zeta -73 mV. The transmission electron microscopy demonstrated spherical droplet morphology. This research produced SNEDDS of lemongrass essential oil with nanoparticle size that can be used as feed additive for poultry

scholarly journals Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span

2019 ◽  
Vol 1 (2) ◽  
pp. 37-46
Author(s):  
Muhamad Handoyo Sahumena ◽  
Suryani Suryani ◽  
Neni Rahmadani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mefenamic Acid ◽  
Tween 80 ◽  
The Body ◽  
Peg 400 ◽  
Span 80 ◽  
Anti Inflammatory ◽  
Optimum Formula

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.

scholarly journals Optimization of self-emulsifying drug delivery system of cefuroxime axetil

2021 ◽  
Vol 66 (2) ◽  
pp. 67-79
Author(s):  
Eleonora Trajanovska ◽  
Maja Simonoska Crcarevska ◽  
Miroslav Mirchev ◽  
Frosina Jovanovikj ◽  
Ana Atanasova ◽  
...  
Keyword(s):  
Neural Network ◽  
Drug Delivery ◽  
Artificial Neural Network ◽  
Experimental Design ◽  
Olive Oil ◽  
Tween 80 ◽  
Cefuroxime Axetil ◽  
Peg 400 ◽  
Artificial Neural Network Ann ◽  
Mixture Experimental Design

Abstract Overcoming solubility problems is the greatest challenge during formulation of poorly soluble active pharmaceutical ingredients (API’s) into oral solid dosage forms. Different formulation approaches were used to surpass this problem and enhance their solubility in the gastrointestinal (GI) fluids, in order to achieve a faster dissolution and better absorption, which will directly influence their therapeutic effect. In this paper, an evaluation of the potential of a self-emulsifying drug delivery system (SEDDS) to improve the solubility of the active ingredient cefuroxime axetil (CA) was done. Screening of the solubility of the API in different excipients was done, and Tween 80, PEG 400, and Olive oil as a surfactant, co-solvent, and oil, respectively, were chosen as the most convenient system constituents. An optimal self-emulsification and solubilization ability of this system was assessed using mixture experimental design statistical tools based on the response surface methodology (RSM). The prepared CA-SEDDS were evaluated for droplet size (d10, d50, d90 in µm), droplet size distribution (Span factor), and absorbance. As a complementary approach, for better representation of the non-linear relationship between the formulation compositions and the observed dispersion characteristics an artificial neural network (ANN) was used. Optimal formulation that consists of 10% (w/w) Tween 80 as surfactant, 80% (w/w) PEG 400 as co-solvent and 10% (w/w) Olive oil, was obtained. Both, mixture experimental design and ANN were combined for a comprehensive evaluation of CA-SEDDS and the obtained results suggested that formulation of SEDDS is a useful approach for improving the solubility of the CA. Keywords: self-emulsifying drug delivery systems (SEDDS), cefuroxime axetil, design of experiment, artificial neural network (ANN)

scholarly journals Formulation and evaluation of self nano-emulsifying drug delivery system of ezetimibe for dissolution rate enhancement

2020 ◽  
Vol 11 (2) ◽  
pp. 1294-1301
Author(s):  
Geethanjali K ◽  
Vaiyana Rajesh C
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Dissolution Rate ◽  
Delivery System ◽  
Tween 80 ◽  
In Vitro Dissolution ◽  
Cinnamon Oil ◽  
Peg 400 ◽  
Solid Form

The present study was aimed to develop a Self Nano Emulsifying Delivery System of Ezetimibe (EZM) for enhancing its dissolution rate. Ezetimibe is a cholesterol absorption inhibitor, being a lipophilic drug due to its low solubility EZM shows a low dissolution profile. The SNEDDS formulation consisted of excipients Cinnamon oil, Tween 80, PEG 400 as the Oil, Surfactant and Co-surfactant. Twelve formulations with different ratios of Oil, Surfactant and Co-surfactant were prepared. The liquid SNEDDS were then converted into Solid form by adsorption technique using Avicel PH 101 and Aerosil 200 as adsorbents. The liquid SNEDDS was characterised for Particle size, Emulsification time, Dispersibility, percentage transmittance, PCM, Centrifugation, Cloud Point and Freeze thaw cycle. The solid form was characterized for the flow property, SEM, Drug content and in-vitro dissolution. Among the twelve formulations F6 formulation was found to have a particle size of 196 nm and PDI of 0.123. F6 formulation was selected as the best and it was made into solid by adsorption onto solid carriers. The F6 formulation consisted of the 25% Cinnamon oil, 50% tween 80 and 25% PEG 400. The in-vitro dissolution rate of the prepared formulation was compared with the marketed formulation. The in-vitro dissolution data showed that the drug release at the end of 60 mins from marketed formulation was 63.75 % and from SNEDDS formulation was         90.62 %. The dissolution rate of the prepared SNEDDS was increased by 1.42 times than the marketed formulation. The increase in the dissolution rate shows that SNEDDS is a suitable drug delivery system to enhance the rate of dissolution of Ezetimibe.

scholarly journals DESIGN AND EVALUATION OF SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEMS OF ALVERINE FOR ENHANCEMENT OF SOLUBILITY

2021 ◽  
Vol 12 (7) ◽  
pp. 25-31
Author(s):  
Pooja . ◽  
Pankaj Kumar Sharma ◽  
Viswanath Agrahari
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Ethyl Oleate ◽  
Spherical Shape ◽  
Tween 80 ◽  
In Vitro Dissolution ◽  
Transmission Electron ◽  
The Stability

Background: The aim of this study is to develop a liquid self-nano emulsifying drug delivery system for alverine (liquid-SNEDDS).Excipients in the alverine SNEDDS include Ethyl oleate as the oil phase, Tween 80 as a surfactant, and PEG600, Propylene glycol as a cosurfactant.The prepared eleven formulations of alverine SNEDDS were performed for emulsification time, percentage transmittance, particle size, drug release, in vitro dissolution and stability studies.The optimised alverine liquid SNEDDS formulation (D1) was studied for drug-excipient compatibility using infrared spectroscopy, as well as particle size, zeta potential, transmission electron microscopy, and stability. Alverine SNEDDS have a spherical shape with uniform particle distribution, according to their morphology. D1's optimised formulation's drug release percentage (96.6). The stability data revealed no discernible changes in drug content, emulsifying properties, drug release, or appearance. As a result, a potential SNEDDS formulation of alverine with improved solubility, dissolution rate, and bioavailability was developed.

scholarly journals Validasi Penetapan Kadar Isolat Andrografolid dari Tanaman Sambiloto (Andrographis paniculata Nees) Menggunakan HPLC

2015 ◽  
Vol 2 (1) ◽  
pp. 8 ◽  
Author(s):  
Yandi Syukri ◽  
Agung Endro Nugroho ◽  
Ronny Martien ◽  
Endang Lukitaningsih
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tween 80 ◽  
Andrographis Paniculata ◽  
Peg 400

Penelitian ini bertujuan untuk mengembangkan analisis kuantitatif untuk penentuan kadar isolat andrographolide dari tanaman sambiloto (Andrographis paniculata) dan pelarut yang berbeda untuk studi awal untuk pembuatan Self Nanoemulsifying Drug Delivery System (SNEDDS) menggunakan KCKT. Pemisahan menggunakan kolom Sunfire C18 dengan campuran isokratik metanol dan air dengan perbandingan 6: 4, v / v sebagai fase gerak. Metode untuk menentukan isolat andrographolide menunjukkan presisi yang memadai, dengan RSD lebih kecil dari 1%. Akurasi dianalisis dengan menambahkan andrografolid standar, dan didapatkan nilai perolehan kembali yang baik untuk semua konsentrasi yang digunakan. Metode HPLC yang dikembangkan dalam penelitian ini menunjukkan spesifisitas dan selektivitas dengan linearitas dalam rentang kerja dan presisi dan akurasi yang baik, sehingga sangat cocok untuk menentukan kandungan isolat andrografolida. Dibandingkan dengan standar, kemurnian isolat andrografolida adalah 95,74 ± 0,29%. Penelitian awal untuk menentukan kelarutan tertinggi isolat andrographolid adalah dalam fasa minyak Capryol-90 1,226 ± 0,009 mg mL-1, surfaktan tween 80 2,965 ± 0.014 mg mL-1 dan co-surfaktan PEG 400 6,074 ± 0,101 mg mL-1. Dapat disimpulkan, metode ini cocok digunakan untuk penentuan kelarutan dari isolat andrographolide untuk pembuatan SNEDDS.

Effect Of Surfactant Chain Length On Emulsification Dynamics Of Self Emulsifying Formulation Of Poorly Soluble Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Shailendra Chouhan ◽  
Lalit Singh Chauhan
Keyword(s):  
Chain Length ◽  
Tween 80 ◽  
Tween 20 ◽  
Almond Oil ◽  
Peg 400 ◽  
Globule Size ◽  
Poorly Soluble ◽  
Tween 40 ◽  
Poorly Soluble Drug ◽  
Tween 60

Aim: In this work the aim was to study the chain length of surfactant on the self emulsifying system of a poorly soluble drug, aceclofenac. The selection of almond oil as a lipid vehicle was done on basis of solubility and compatibility of the vehicle with the drug. Methods: The effect of varying chain length of different surfactants of Tween series namely Tween 20, Tween 40, Tween 60 and Tween 80 was evaluated on self emulsifying efficiency by constructing pseudoternary diagrams. PEG-400 was used as co-surfactant in a definite ratio with all the surfactants to minimize their concentration. The best self emulsifying ability was exhibited by Tween 80: PEG-400 combination followed by Tween 60: PEG-400, Tween 40: PEG-400, Tween 20: PEG-400. This observation indicates that as the chain length of Tweens increases their ability to form a good microemulsion increases if same co-surfactant is used. Results: However it has also been found that the presence of unsaturated bond in Tween 80 provides it an elasticity which supports good intermixing of oil and water and leading to formation of a fine microemulsion. Six different formulations were prepared using combination of almond oil, Tween 80, PEG-400 and the drug aceclofenac. Conclusion : The formulations were subjected to various evaluation parameters such as dispersibility, transmittance, pH, globule size, polydispersibility, zeta potential, viscosity, refractive index and in vitro dissolution. The best formulation was found to have globule size of less than 100 nm, zeta potential of -3.35 ± 0.60 mV which indicates formation of a microemulsion of aceclofenac with good stability.

scholarly journals Formulation and Characterization of Glibenclamide Solid Lipid Submicroparticles Formated by Virgin Coconut Oil and Solid Matrix Surfactant

2021 ◽  
Vol 6 (2) ◽  
pp. 58-66
Author(s):  
Mardiyanto Mardiyanto ◽  
Najma Annuria Fithri ◽  
Annisa Amriani ◽  
Herlina Herlina ◽  
Dwi Purnama Sari
Keyword(s):  
Zeta Potential ◽  
Physical Stability ◽  
Coconut Oil ◽  
Tween 80 ◽  
Solid Matrix ◽  
Virgin Coconut Oil ◽  
Cooling Cycle ◽  
Solid Lipid ◽  
Optimum Formula

Glibenclamide has the biopharmaceutics classification system (BCS) class II which has high permeability and low solubility. The solubility of glibenclamide can be enhanced by forming solid lipid nanoparticles (SLN). This research has the aim to prepare and characterize SLN loading glibenclamide. The glibenclamide SLN formula was composed by using the liquid lipid as virgin coconut oil (VCO), PEG 6000 as a solid matrix, tween 80 with various concentrations as a stabilizer, and PEG 400 as co-surfactant. Characterization was conducted by determining the encapsulation efficiency (%EE), size measurement, particle size distribution, and zeta potential of SLN glibenclamide. SLN formation was also tested for its physical stability based on the heating-cooling cycle method. The optimum formula was obtained at the concentration of tween-80 of 1 mg/mL yielding the %EE value of 60.6194%, and pH 6.01. The results of particles diameter analysis were 175.5 ± 10.07 nm with a polydispersity index (PDI) of 0.1270, and zeta potential of +5.9 mV respectively. Stability testing by the heating-cooling cycle method has shown the instability of the SLN glibenclamide form under extreme temperatures and mechanics. It could be concluded that the results of characterization of glibenclamide SLN showed appropriate physical properties for nanoparticulate formulation.

scholarly journals Skrining Berbagai Jenis Surfaktan Dan Kosurfaktan Sebagai Dasar Pemilihan Formulasi Nanoemulsi

2021 ◽  
Vol 1 (3) ◽  
pp. 158-166
Author(s):  
Ni Luh Putu Karunia Vidya Nirmalayanti
Keyword(s):  
Phase Diagram ◽  
Propylene Glycol ◽  
Research Method ◽  
Tween 80 ◽  
Tween 20 ◽  
Peg 400 ◽  
Tween 60 ◽  
Main Components ◽  
Optimum Formula ◽  
Pseudoternary Phase Diagram

The main components for making nanoemulsions are oil, surfactants, and cosurfactants. Before formulating nanoemulsions, screening the surfactants and cosurfactants is necessary to produce an optimum formula. Thus, it carries out surfactants screening, namely (tween 20, tween 60, tween 80) and cosurfactants (propyleneglycol, PEG 400, glycerin). This study aimed to screen suitable selection and cosurfactants as the basis for making nanoemulsions. Then, the research method was carried out in two ways: surfactant screening and cosurfactant screening. The final results were analyzed using a pseudoternary phase diagram. The surfactant screening results were tween 20 (40mL), tween 60 (40mL), tween 80 (60mL); thereby, the best surfactant candidate was tween 80. The results of the surfactant screening on the pseudoternary phase diagram are the most optimal, namely tween 80 with propylene glycol because it has a large nanoemulsion formation area. The study proposed the ratio of oil: smix (tween 80 and propyleneglycol) (1:9) as the optimum formula used to make a nanoemulsion base.

scholarly journals OPTIMASI PEMBUATAN NANOEMULSI VIRGIN COCONUT OIL

Jurnal Kimia ◽  
2018 ◽  
pp. 8
Author(s):  
N. M. D. Listyorini ◽  
N. L. P. D. Wijayanti ◽  
K. Widnyani Astuti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Coconut Oil ◽  
Tween 20 ◽  
Virgin Coconut Oil ◽  
Spontaneous Emulsification ◽  
Peg 400

Penelitian ini mempelajari optimasi pembuatan nanoemulsi menggunakan virgin coconut oil (VCO) yang bertujuan untuk memperoleh perbandingan minyak (VCO), surfaktan dan kosurfaktan yang dapat membentuk nanoemulsi yang memenuhi persyaratan menggunakan Self Nano-Emulsifying Drug Delivery System (SNEDDS). Metode yang digunakan adalah Spontaneous Emulsification yang termasuk ke dalam SNEDDS. Perbandingan yang digunakan dalam nanoemulsi yaitu minyak (VCO): surfaktan (Cremophor RH40 atau Tween 20): kosurfaktan (PEG 400 atau etanol): fase air (akua deion) dengan perbandingan (1:8:1):5, (1:7:2):5 dan (2:7:1):5 yang menghasilkan 12 buah formula. Dilakukan uji evaluasi berupa uji stabilitas isik dan persen transmitan ke-12 formula. Diperoleh 2 formula yang dilanjutkan untuk uji zeta potensial dan ukuran partikel yaitu F2 dan F7. Uji zeta potensial F2 (0,14 mV) dan F7 (0,48 mV) serta uji ukuran partikel F2 (20,8 nm) dan F7 (20,6 nm). Berdasarkan hasil uji evaluasi yang dilakukan maka diperoleh dua formula yaitu F2 (VCO: Cremophor RH40: PEG 400 (1: 8:1)) dan F7 (VCO: Cremophor RH40: Etanol (1: 7: 2)) yang sesuai persyaratan untuk menghasilkan nanoemulsi yang baik.

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