Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring

To examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats borne to dams with gestational HFD/obesity. Then, we assessed the possible priming effect of a subsequent insult, male offspring were weaned onto either a rat chow or a HFD. Spatial learning and memory were assessed by Morris water maze test. Blood pressure and peripheral insulin resistance were examined. Maternal HFD/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pAKT), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor (BDNF) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. Maternal resveratrol treatment restored adiponectin, pAKT, and BDNF in fetal brain. It also reduced body weight, peripheral insulin resistance, increased blood pressure, and alleviated cognitive impairment in adult male offspring with combined maternal HFD and postnatal HFD. Maternal resveratrol treatment restored hippocampal pAKT and BDNF in rats with combined maternal HFD and postnatal HFD in adult male offspring dorsal hippocampus. Maternal resveratrol intake protects the fetal brain in the context of maternal HFD/obesity. It effectively reduced the synergistic effects of maternal HFD/obesity and postnatal HFD on metabolic disturbances and cognitive impairment in adult male offspring. Our data suggest that maternal resveratrol intake may serve as an effective therapeutic strategy in the context of maternal HFD/obesity.

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The inflammatory environment mediated by a high-fat diet inhibited the development of mammary glands and destroyed the tight junction in pregnant mice.

Food & Function ◽

10.1039/d0fo00609b ◽

2020 ◽

Vol 11 (9) ◽

pp. 8193-8201

Author(s):

Wenjin Guo ◽

Juxiong Liu ◽

Shuang Hou ◽

Guiqiu Hu ◽

He Ma ◽

...

Keyword(s):

Mammary Gland ◽

Tight Junction ◽

Pregnant Women ◽

High Fat Diet ◽

Mammary Glands ◽

High Fat ◽

Pregnant Mice

Long-term intake of a high-fat diet seriously affects the health of pregnant women and leads to increased levels of inflammation in the mammary gland.

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A Maternal High Fat Diet Programmes Endothelial Function and Cardiovascular Status in Adult Male Offspring Independent of Body Weight, Which is Reversed by Maternal Conjugated Linoleic Acid (CLA) Supplementation

PLoS ONE ◽

10.1371/journal.pone.0115994 ◽

2015 ◽

Vol 10 (2) ◽

pp. e0115994 ◽

Cited By ~ 18

Author(s):

Clint Gray ◽

Mark H. Vickers ◽

Stephanie A. Segovia ◽

Xiaohuan D. Zhang ◽

Clare M. Reynolds

Keyword(s):

Body Weight ◽

Linoleic Acid ◽

Endothelial Function ◽

Conjugated Linoleic Acid ◽

Adult Male ◽

High Fat Diet ◽

Male Offspring ◽

High Fat

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Maternal high-fat diet programs white and brown adipose tissue lipidome and transcriptome in offspring in a sex- and tissue-dependent manner in mice

International Journal of Obesity ◽

10.1038/s41366-021-01060-5 ◽

2022 ◽

Author(s):

Christina Savva ◽

Luisa A. Helguero ◽

Marcela González-Granillo ◽

Tânia Melo ◽

Daniela Couto ◽

...

Keyword(s):

High Fat Diet ◽

Metabolic Profile ◽

Maternal Diet ◽

Overweight And Obesity ◽

Male Offspring ◽

Metabolic Adaptation ◽

Dependent Manner ◽

High Fat ◽

The Metabolic Syndrome ◽

Metabolic Complication

Abstract Objective The prevalence of overweight and obesity among children has drastically increased during the last decades and maternal obesity has been demonstrated as one of the ultimate factors. Nutrition-stimulated transgenerational regulation of key metabolic genes is fundamental to the developmental origins of the metabolic syndrome. Fetal nutrition may differently influence female and male offspring. Methods Mice dam were fed either a control diet or a high-fat diet (HFD) for 6-week prior mating and continued their respective diet during gestation and lactation. At weaning, female and male offspring were fed the HFD until sacrifice. White (WAT) and brown (BAT) adipose tissues were investigated in vivo by nuclear magnetic resonance at two different timepoints in life (midterm and endterm) and tissues were collected at endterm for lipidomic analysis and RNA sequencing. We explored the sex-dependent metabolic adaptation and gene programming changes by maternal HFD in visceral AT (VAT), subcutaneous AT (SAT) and BAT of offspring. Results We show that the triglyceride profile varies between adipose depots, sexes and maternal diet. In female offspring, maternal HFD remodels the triglycerides profile in SAT and BAT, and increases thermogenesis and cell differentiation in BAT, which may prevent metabolic complication later in life. Male offspring exhibit whitening of BAT and hyperplasia in VAT when born from high-fat mothers, with impaired metabolic profile. Maternal HFD differentially programs gene expression in WAT and BAT of female and male offspring. Conclusion Maternal HFD modulates metabolic profile in offspring in a sex-dependent manner. A sex- and maternal diet-dependent gene programming exists in VAT, SAT, and BAT which may be key player in the sexual dimorphism in the metabolic adaptation later in life.

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