scholarly journals Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites

2008 ◽  
Vol 586 (6) ◽  
pp. 1495-1502 ◽  
Author(s):  
Kenneth A. Pelkey ◽  
Chris J. McBain
Keyword(s):  
Target Cell ◽  
Mossy Fibre ◽  
Dependent Plasticity ◽  
Presynaptic Function

scholarly journals Compartmentalized Ca2+ Channel Regulation at Divergent Mossy-Fiber Release Sites Underlies Target Cell-Dependent Plasticity

Neuron ◽  
2006 ◽  
Vol 52 (3) ◽  
pp. 497-510 ◽  
Author(s):  
Kenneth A. Pelkey ◽  
Lisa Topolnik ◽  
Jean-Claude Lacaille ◽  
Chris J. McBain
Keyword(s):  
Target Cell ◽  
Mossy Fiber ◽  
Dependent Plasticity ◽  
Channel Regulation

Ultrastructural Changes in Tumor Cells During Human Peripheral Blood Monocyte-Mediated Cytotoxicity

1981 ◽  
Vol 39 ◽  
pp. 452-453
Author(s):  
K. E. Muse ◽  
D. G. Fischer ◽  
H. S. Koren
Keyword(s):  
Target Cell ◽  
Human Peripheral Blood ◽  
Mononuclear Phagocytes ◽  
Ultrastructural Changes ◽  
Target Cells ◽  
Limited Information ◽  
Blood Monocytes ◽  
Tumoricidal Activity ◽  
Activated State

Mononuclear phagocytes, a pluripotential cell line, manifest an array of basic extracellular functions. Among these physiological regulatory functions is the expression of spontaneous cytolytic potential against tumor cell targets.The limited observations on human cells, almost exclusively blood monocytes, initially reported limited or a lack of tumoricidal activity in the absence of antibody. More recently, freshly obtained monocytes have been reported to spontaneously impair the biability of tumor target cells in vitro (Harowitz et al., 1979; Montavani et al., 1979; Hammerstrom, 1979). Although the mechanism by which effector cells express cytotoxicity is poorly understood, discrete steps can be distinguished in the process of cell mediated cytotoxicity: recognition and binding of effector to target cells,a lethal-hit stage, and subsequent lysis of the target cell. Other important parameters in monocyte-mediated cytotoxicity include, activated state of the monocyte, effector cell concentrations, and target cell suseptibility. However, limited information is available with regard to the ultrastructural changes accompanying monocyte-mediated cytotoxicity.

Rehabilitation of Attention

2003 ◽  
Vol 14 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Ian H. Robertson
Keyword(s):  
Brain Damage ◽  
Dependent Plasticity ◽  
Attention Systems ◽  
The Brain

Abstract: In this paper, evidence is reviewed for separable attention systems in the brain, and it is argued a) that attention may have a privileged role in mediating experience dependent plasticity in the brain and b) that at least some types of attention may be capable of rehabilitation following brain damage.

COVID 19 – Eye Issues

2020 ◽  
Vol 5 (Special) ◽  
Keyword(s):  
Host Cell ◽  
Target Cell ◽  
Cell Receptor ◽  
Human Tissues ◽  
Type Ii ◽  
Cell Infection ◽  
Host Cell Receptor ◽  
Infected Cells ◽  
Cellular Entry

The coronavirus illness (COVID-19) is caused by a new recombinant SARS-CoV (SARS-CoV) virus (SARS-CoV-2). Target cell infection by SARS-CoV is mediated by the prickly protein of the coronavirus and host cell receptor, enzyme 2 converting angiotensin (ACE2) [3]. Similarly, a recent study suggests that cellular entry by SARS-CoV-2 is dependent on both ACE2 as well as type II transmembrane axial protease (TMPRSS2) [4]. This means that detection of ACE2 and PRSS2 expression in human tissues can predict potential infected cells and their respective effects in COVID-19 patients [1].

Impaired in vivo insulin clearance in patients with severe target-cell resistance to insulin

Diabetes ◽  
1982 ◽  
Vol 31 (2) ◽  
pp. 132-135 ◽  
Author(s):  
J. S. Flier ◽  
K. L. Minaker ◽  
L. Landsberg ◽  
J. B. Young ◽  
J. Pallotta ◽  
...  
Keyword(s):  
Target Cell ◽  
Insulin Clearance ◽  
Cell Resistance ◽  
Resistance To Insulin

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

Fas-mediated Lysis of Target Cell by IL-2 Treated Cytotoxic T Lymphocytes.

2002 ◽  
Vol 49 (3) ◽  
pp. 119-129 ◽  
Author(s):  
AKIRA AKASHI ◽  
KOICHI KUWANO
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Target Cell
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