The Role of Engineering Critical Assessment in the Life Extension of Risers Connected to Floating Systems

There are two main bioengineering approaches to extending the half-life of factor (F)VIII or FIX products used for hemophilia replacement therapy. These are fusion to Fc-immunoglobulin G (FVIII and FIX) or to albumin (FIX) or pegylation/glycopegylation (FVIII and FIX). Four FVIII and three FIX products are in clinical development or have recently been licensed in regions of the world. The reported half-life extension is approximately 1.5-fold for FVIII and 2.5-fold, or even longer, for FIX. Clinical trials have shown promising results with respect to extension of dose intervals and efficacy in the treatment and prevention of bleeding events. The role of these products in clinical practice has been discussed in terms of either improving convenience and adherence through prolongation of the interval between infusions or maintaining current intervals thereby increasing trough levels and the safety margin against bleeds. This review of extended half-life products addresses the possibilities and problems of their introduction in hemophilia treatment.

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The Catch of the Hyperreal: Yossarian and the Ideological Vicissitudes of Hyperreality

Text Matters ◽

10.1515/texmat-2018-0023 ◽

2018 ◽

pp. 386-410

Author(s):

Abdolali Yazdizadeh

Keyword(s):

Twentieth Century ◽

Cultural Theory ◽

Critical Assessment ◽

Vantage Point ◽

The Novel ◽

Fictional World ◽

American Life ◽

Ideological Discourse ◽

Catch 22

Hyperreality is a key term in Jean Baudrillard’s cultural theory, designating a phase in the development of image where it “masks the absence of a profound reality.” The ambiance of Joseph Heller’s Catch-22 (1961) closely corresponds to Baudrillard’s notion of the hyperreal as images persist to precede reality in the fictional world of the novel. Since for Baudrillard each order of simulacra produces a certain mode of ideological discourse that impacts the perception of reality, it is plausible that the characters of this fictional context should be ideologically impacted by the hyperreal discourse. From this vantage point it is possible to have a new critical assessment of Yossarian’s (protagonist) antiheroic stance and study the role of the “business of illusion,” whose ideological edifice is based on the discourse of the hyperreal, on his antiheroic stance and actions. By drawing on Baudrillard’s cultural theory this paper aims to read Heller’s novel as a postmodern allegory of rebellion against the hyperreality of the twentieth-century American life and trace its relevance to modern-day U.S.

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Raja yoga within the system of religious-ethical philosophy Of M. V. Lodyzhensky

Философская мысль ◽

10.25136/2409-8728.2020.11.33579 ◽

2020 ◽

pp. 64-90

Author(s):

Oleg Viktorovich Solopov

Keyword(s):

Critical Review ◽

Scientific Literature ◽

Critical Assessment ◽

Special Role ◽

The Novel ◽

Ethical Philosophy ◽

Knowledge Ontology ◽

Comprehensive Study

This article is dedicated to examination of the characteristics of the doctrine of Raja yoga in interpretation Of M. V. Lodyzhensky. The goal consists in the analysis and reconstruction of the system of Raja yoga within the religious-ethical philosophy of the thinker. In the course of this research, the author resolves a number of problems: examines the system of primary elements of religious-ethical philosophy of M. V. Lodyzhensky; analyzes the sources that affected the formation of views of the philosopher upon Raja yoga; reveals main characteristics of the system of Raja yoga within Lodyzhensky’s philosophy; determines the peculiarities of religious-mystical practice of Raja yoga in the philosophy of M. V. Lodyzhensky; defines the role of Raja-yoga within the system of religious-ethical philosophy of the thinker. The novelty lies in determination of the novel in comparison to the existing in scientific literature categories of M. V. Lodyzhensky’s philosophy and their analysis in the context of system of fundamental sections of philosophical knowledge (ontology, theology, anthropology, epistemology, axiology, ethics); as well as in comprehensive study of the system of Raja yoga in interpretation Of M. V. Lodyzhensky and determination of its role within the structure of his philosophy. It is established that the “core” of the system of religious-ethical philosophy of M. V. Lodyzhensky is the ethics develop ethics and axiology of Hesychasm developed by him. It is proven that the system of metaphysical categories and ideas of the thinker is of synthetic nature and leans on various cultural trends and traditions. The article demonstrates that special role within the system of Lodyzhensky’s philosophy is played by the apologetics of Hesychasm that implies critical review of the non-Christian mystical practices, among which is the examination of Raja yoga. The author underlines the uniqueness of interpretation of Raja yoga in the philosophy M. V. Lodyzhensky, as well as provides critical assessment to his interpretation of the system of Raja yoga.

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