scholarly journals Reproduction Differentially Affects Trabecular Bone Depending on Its Mechanical Versus Metabolic Role

2017 ◽  
Vol 139 (11) ◽  
Author(s):  
Chantal M. J. de Bakker ◽  
Wei-Ju Tseng ◽  
Yihan Li ◽  
Hongbo Zhao ◽  
Allison R. Altman-Singles ◽  
...  

During pregnancy and lactation, the maternal skeleton provides calcium for fetal/infant growth, resulting in substantial bone loss, which partially recovers after weaning. However, the amount of bone that is lost and the extent of post-weaning recovery are highly variable among different skeletal sites, and, despite persistent alterations in bone structure at some locations, reproductive history does not increase postmenopausal fracture risk. To explain this phenomenon, we hypothesized that the degree of reproductive bone loss/recovery at trabecular sites may vary depending on the extent to which the trabecular compartment is involved in the bone’s load-bearing function. Using a rat model, we quantified the proportion of the load carried by the trabeculae, as well as the extent of reproductive bone loss and recovery, at two distinct skeletal sites: the tibia and lumbar vertebra. Both sites underwent significant bone loss during pregnancy and lactation, which was partially recovered post-weaning. However, the extent of the deterioration and the resumption of trabecular load-bearing capacity after weaning varied substantially. Tibial trabecular bone, which bore a low proportion of the total applied load, underwent dramatic and irreversible microstructural deterioration during reproduction. Meanwhile, vertebral trabecular bone bore a greater fraction of the load, underwent minimal deterioration in microarchitecture, and resumed its full load-bearing capacity after weaning. Because pregnancy and lactation are physiological processes, the distinctive responses to these natural events among different skeletal sites may help to elucidate the extent of the trabecular bone’s structural versus metabolic functions.

Author(s):  
Larisa Linetska ◽  
Igor Linetskiy ◽  
Vladyslav Demenko ◽  
Vitalij Nesvit ◽  
Oleg Yefremov

2019 ◽  
Vol 30 (S19) ◽  
pp. 193-193
Author(s):  
Larysa Linetska ◽  
Oleg Yefremov ◽  
Vladislav Demenko ◽  
Igor Linetskiy ◽  
Vitalij Nesvit

2020 ◽  
Vol 62 (1) ◽  
pp. 55-60
Author(s):  
Per Heyser ◽  
Vadim Sartisson ◽  
Gerson Meschut ◽  
Marcel Droß ◽  
Klaus Dröder

2017 ◽  
Vol 68 (1) ◽  
pp. 94-100
Author(s):  
Oana Tanculescu ◽  
Adrian Doloca ◽  
Raluca Maria Vieriu ◽  
Florentina Mocanu ◽  
Gabriela Ifteni ◽  
...  

The load-bearing capacity and fracture pattern of direct inlay-retained FRC FDPs with two different cross-sectional designs of the ponticwere tested. The aim of the study was to evaluate a new fibre disposition. Two types of composites, Filtek Bulk Fill Posterior Restorative and Filtek Z250 (3M/ESPE, St. Paul, MN, USA), and one braided polyethylene fibre, Construct (Kerr, USA) were used. The results of the study suggested that the new tested disposition of the fibres prevented in some extend the delamination of the composite on buccal and facial sides of the pontic and increased the load-bearing capacity of the bridges.


2021 ◽  
Vol 60 (1) ◽  
pp. 503-518
Author(s):  
Juan Han ◽  
Lu Zhu ◽  
Hai Fang ◽  
Jian Wang ◽  
Peng Wu

Abstract This article proposed an innovative composite sandwich structure reinforced with trapezoidal latticed webs with angles of 45°, 60° and 75°. Four specimens were conducted according to quasi-static compression methods to investigate the compressive behavior of the novel composite structures. The experimental results indicated that the specimen with 45° trapezoidal latticed webs showed the most excellent energy absorption ability, which was about 2.5 times of the structures with vertical latticed webs. Compared to the traditional composite sandwich structure, the elastic displacement and ultimate load-bearing capacity of the specimen with 45° trapezoidal latticed webs were increased by 624.1 and 439.8%, respectively. Numerical analysis of the composite sandwich structures was carried out by using a nonlinear explicit finite element (FE) software ANSYS/LS-DYNA. The influence of the thickness of face sheets, lattice webs and foam density on the elastic ultimate load-bearing capacity, the elastic displacement and initial stiffness was analyzed. This innovative composite bumper device for bridge pier protection against ship collision was simulated to verify its performance. The results showed that the peak impact force of the composite anti-collision device with 45° trapezoidal latticed webs would be reduced by 17.3%, and the time duration will be prolonged by about 31.1%.


Friction ◽  
2021 ◽  
Author(s):  
Luyao Gao ◽  
Xiaoduo Zhao ◽  
Shuanhong Ma ◽  
Zhengfeng Ma ◽  
Meirong Cai ◽  
...  

AbstractSilicone elastomers-based materials have been extensively involved in the field of biomedical devices, while their use is extremely restricted due to the poor surface lubricity and inherent hydrophobicity. This paper describes a novel strategy for generating a robust layered soft matter lubrication coating on the surface of the polydimethylsiloxane (PDMS) silicone elastomer, by entangling thick polyzwitterionic polyelectrolyte brush of poly (sulfobetaine methacrylate) (PSBMA) into the sub-surface of the initiator-embedded stiff hydrogel coating layer of P(AAm-co-AA-co-HEMA-Br)/Fe, to achieve a unified low friction and high load-bearing properties. Meanwhile, the stiff hydrogel layer with controllable thickness is covalently anchored on the surface of PDMS by adding iron powder to provide catalytic sites through surface catalytically initiated radical polymerization (SCIRP) method and provides high load-bearing capacity, while the topmost brush/hydrogel composite layer is highly effective for aqueous lubrication. Their synergy effects are capable of attaining low friction coefficient (COFs) under wide range of loaded condition in water environment with steel ball as sliding pair. Furthermore, the influence of mechanical modulus of the stiff hydrogel layer on the lubrication performance of layered coating is investigated, for which the COF is the lowest only when the modulus of the stiff hydrogel layer well matches the PDMS substrate. Surprisingly, the COF of the modified PDMS could remain low friction (COF < 0.05) stably after encountering 50,000 sliding cycles under 10 N load. Finally, the surface wear characterizations prove the robustness of the layered lubricating coating. This work provides a new route for engineering lubricious silicon elastomer with low friction, high load-bearing capacity, and considerable durability.


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