Injection Molding of Tissue Engineered Tympanic Membrane Patches Utilizing Computer-Aided Design

2001 ◽  
Author(s):  
Morgan E. Hott ◽  
Richard M. Beane ◽  
Cliff Megerian ◽  
Lawrence J. Bonassar
Keyword(s):  
General Anesthesia ◽  
Tympanic Membrane ◽  
Computer Aided Design ◽  
Surgical Repair ◽  
The United States ◽  
Office Procedure ◽  
Autologous Tissue ◽  
Tympanostomy Tubes ◽  
Aided Design ◽  
Membrane Patch

Abstract Over two million tympanostomy tubes are inserted annually in the United States, making this the most commonly performed of all surgical procedures (Isaacson 1996). In approximately 10% of cases the patient treated with tympanostomy tubes is left with a permanent perforation of the tympanic membrane that requires surgical repair. Current surgical technique involves grafting of an autologous tissue such as temporalis fascia or tragal cartilage to the perforated membrane (Paterson 1999). This is an involved surgical procedure requiring general anesthesia. We propose tissue engineering an autologous cartilage tympanic membrane patch. If successful this approach has the potential to transform an operating room procedure to an office procedure. This would provide tremendous healthcare savings, and potentially obviate the need for tens of thousands of children to undergo general anesthesia.

Care of the Child With Tympanostomy Tubes: A Visual Guide for the Pediatrician

PEDIATRICS ◽  
1994 ◽  
Vol 93 (6) ◽  
pp. 924-929
Author(s):  
Glenn Isaacson ◽  
Richard M. Rosenfeld
Keyword(s):  
Tympanic Membrane ◽  
Personal Communication ◽  
The United States ◽  
Tympanic Membrane Perforation ◽  
Nonsurgical Management ◽  
Tympanostomy Tubes ◽  
Membrane Perforation ◽  
Middle Ear Disease ◽  
Available Information

More than 2 million tympanostomy tubes are placed annually in the United States, primarily in children with chronic or recurrent otitis media refractory to nonsurgical management (J.S. Reilly, personal communication, 1994). Traditionally, the operating otolaryngologist has had the responsibility of caring for these patients, including: confirming middle ear disease, assuring tube patency, controlling refractory otorrhea, and managing complications such as tympanic membrane perforation or cholesteatoma. In response to pressures from a changing health care system, pediatricians are less able to refer children back to the otolaryngologist for routine tube surveillance, and must therefore perform it themselves, often with incomplete instrumentation and training. An approach is presented here for the care of the child with tympanostomy tubes based on the authors' combined experience with thousands of intubated children, and on available information from the pediatric and otolaryngic literature. With appropriate postoperative surveillance and follow-up care, the morbidity from tympanostomy tubes can be minimized. Although there are other ways of achieving the same goals, these time-honored methods are safe and effective. Because this is a visual guide, photographs are liberally interspersed to clarify and reinforce the written material. NORMAL TUBE APPEARANCE There are hundreds of different tube designs and materials and at least five different potential insertion sites in the tympanic membrane. This bewildering array of devices can be reduced to two general types: short-term tubes (intended to remain in the eardrum for 8 to 15 months) and long-term tubes (intended to remain in the eardrum > 15 months) (Fig 1A and B).

Repair of Chronic Tympanic Membrane Perforations Using Epidermal Growth Factor

1992 ◽  
Vol 107 (5) ◽  
pp. 669-683 ◽  
Author(s):  
C. Philip Amoils ◽  
Robert K. Jackler ◽  
Lawrence R. Lustig
Keyword(s):  
Hearing Loss ◽  
Tympanic Membrane ◽  
Surgical Repair ◽  
Conductive Hearing Loss ◽  
Recurrent Infection ◽  
Autologous Tissue ◽  
Tympanic Membrane Perforations ◽  
Epidermal Growth ◽  
Conductive Hearing ◽  
Microsurgical Procedure

Perforation of the tympanic membrane (TM) is a frequent cause of conductive hearing loss. Persistent TM perforations often require surgical repair with an autologous tissue graft to restore hearing and prevent recurrent infection. While highly efficacious, this method of closure requires a relatively complex and expensive microsurgical procedure. We have recently developed a chronic TM perforation model in the chinchilla for use in the exploration of novel methods of TM repair.

scholarly journals Analysis of Engineering Accreditation Process and Outcomes: Lessons Learned for Successful First Time Application

2020 ◽  
Vol 19 (9) ◽  
pp. 281-300
Author(s):  
Tahar Ayadat ◽  
Andi Asiz
Keyword(s):  
Computer Aided Design ◽  
The United States ◽  
Accreditation Process ◽  
Lessons Learned ◽  
Engineering Programs ◽  
Engineering Program ◽  
Senior Design ◽  
Program Compliance ◽  
Aided Design ◽  
First Time

The aims of the paper are to share and analyze engineering accreditation experience starting from the preparation through the outcome, and to discuss lessons learned particularly for first-time applicants. Securing accreditation from a well-recognized international body, such as the Accreditation Board for Engineering and Technology (ABET) can indicate quality of an engineering program. To qualify for an accreditation up to six- to seven-year period, an engineering program must meet a set of accreditation standards or criteria. The article is not limited only for new engineering programs outside the United States who are willing to pursue engineering accreditation from ABET, but it is applicable for an existing accredited program who will undergo next accreditation cycle. The authors presented and analyzed detail accreditation experience for a new established Civil Engineering (CE) Program at Prince Mohammad bin Fahd University (PMU) in Saudi Arabia. Although the ABET website provides detail procedure for the accreditation steps, the detail cases experienced by the PMU CE program will enrich knowledge on how to prepare and handle successful international accreditation. The authors also discussed issues raised during the accreditation activities, including program compliance with the nine ABET criteria, and presented key lessons to prepare for a smooth accreditation process. The main significant result of the accreditation exercise about continuous improvement was summarized in term of the curriculum upgrade, including adding another semester for senior design course and offering new sustainability engineering course, and adding computer aided design course at the early semester.

Fabrication of Tissue Engineered Tympanic Membrane Patches Using Computer-Aided Design and Injection Molding

2004 ◽  
Vol 114 (7) ◽  
pp. 1290-1295 ◽  
Author(s):  
Morgan E. Hott ◽  
Cliff A. Megerian ◽  
Rich Beane ◽  
Lawrence J. Bonassar
Keyword(s):  
Injection Molding ◽  
Tympanic Membrane ◽  
Computer Aided Design ◽  
Computer Aided ◽  
Aided Design

scholarly journals Modelado y Recreación Virtual de Patrimonio Aeronáutico como Innovación Docente en Estudios de Ingeniería = Modelling and Virtual Recreation of Aeronautical Heritage as a Teaching Innovation in Engineering Studies

2021 ◽  
Vol 5 (2) ◽  
pp. 55
Author(s):  
Laura García-Ruesgas ◽  
Eduardo Fernández-González ◽  
Francisco Valderrama-Gual ◽  
Amparo Verdú-Vázquez
Keyword(s):  
Computer Aided Design ◽  
The United States ◽  
Teaching Innovation ◽  
Industrial Heritage ◽  
Professional Activities ◽  
Engineering Studies ◽  
Aeronautical Industry ◽  
Historical Heritage ◽  
Aided Design ◽  
Standard Software

El patrimonio aeronáutico a diferencia de otros como el arquitectónico o industrial no ha sido tan abordado históricamente.Desde hace 20 años, en la Escuela Técnica Superior de Ingeniería de Sevilla, se imparte docencia sobre Diseño y Fabricación Asistidos por Ordenador en sus múltiples titulaciones [2]. En los estudios de Ingeniería Aeroespacial se emplea CATIA, software estándar en la industria aeronáutica europea, Estados Unidos y Canadá [3].Durante el aprendizaje, los alumnos adquieren competencias para realizar modelados y recreaciones virtuales [5], no tan sólo orientadas a sus futuras actividades profesionales, sino también a otras relativas al rescate y catalogación del patrimonio histórico aeronáutico [6].Se presenta en esta comunicación el Modelado y Recreación Virtual del avión biplano Ansaldo SVA 5 [7], cuya documentación de partida consistió en planos realizados a mano y en documentos referentes a los diferentes procesos de verificación del proyecto del avión y a las modificaciones realizadasAbstractThe aeronautical heritage, unlike others such as architectural or industrial heritage, has not been so much addressed historically.For the last 20 years, the Seville School of Engineering has been teaching Computer Aided Design and Manufacturing in its multiple degrees [2]. CATIA, standard software in the aeronautical industry in Europe, the United States and Canada, is used in the Aerospace Engineering studies [3].During the apprenticeship, students acquire skills to perform modelling and virtual recreations [5], not only oriented to their future professional activities, but also to others related to the rescue and cataloguing of the aeronautical historical heritage [6].This paper presents the modelling and virtual recreation of the biplane Ansaldo SVA 5 [7], whose starting documentation consisted of handmade plans and documents relating to the various processes of verification of the aircraft project and the modifications made.

Representing the Charters of Freedom Encasements in a Design Repository: A Case Study

2001 ◽  
Author(s):  
R. H. Allen ◽  
R. J. Fijol ◽  
S. Szykman ◽  
R. D. Sriram
Keyword(s):  
Computer Aided Design ◽  
The United States ◽  
Specific Information ◽  
Design Rationale ◽  
Bill Of Rights ◽  
System A ◽  
Model Geometry ◽  
Aided Design ◽  
Generic Design

Abstract We report on a case study representing, in an evolving design repository, the design essence of new encasements for the United States Charters of Freedom (CoF) — namely the Constitution, the Declaration of Independence and the Bill of Rights. Specifically redesigned for the purpose of housing and preserving our national documents, the nine encasements each consist of three principal systems — a sealing system, a placement system and a safeguarding system. The encasements were needed to replace the ones manufactured in the early 1950s, because of glass deterioration; these newer encasements are designed to last 100 years. To populate the design repository, we represent engineering geometry, function and associated behavior. We model geometry with digital photographs and Virtual Reality Markup Language (VRML) models of actual Computer-Aided Design (CAD) drawings, and represent function with linked textual descriptions. Design rationale is represented explicitly. Through an evolving user interface, this representation serves to capture the more than 50 parts and systems of the encasements in such a way that the information relating to form, function, behavior and rationale is accessible and browsable to interested parties via the Internet. We conclude that such a representation, or ones similar to it, can provide the basis for a generic design repository, in which specific information — including design rationale — can be readily accessed by interested parties.

The 2-Visit CAD-CAM Implant-Retained Overdenture: A Clinical Report

2014 ◽  
Vol 40 (6) ◽  
pp. 722-728 ◽  
Author(s):  
Avinash S. Bidra
Keyword(s):  
United States ◽  
Computer Aided Design ◽  
Scientific Literature ◽  
The United States ◽  
Clinical Report ◽  
Complete Dentures ◽  
Advantages And Disadvantages ◽  
Computer Aided ◽  
Cad Cam ◽  
Aided Design

Recently, computer-aided technology has become commercially available in the United States for fabrication of complete dentures. Manufacturers offering this technology require exclusive clinical and laboratory protocols that sharply contrast with the traditional paradigms of complete denture therapy. These protocols allow fabrication of complete dentures in only 2 clinical appointments. Currently, there are no clinical reports in the scientific literature describing the use of this technology for overdentures. This article describes the successful use of computer aided design-computer aided machining (CAD-CAM) technology for prosthodontic phase of fabrication of a mandibular implant-retained overdenture in only 2 clinical appointments. A discussion of the techniques, rationale, indications, advantages, and disadvantages of using CAD-CAM technology for complete dentures and overdentures are described in this article.

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