Age-Related Differences in the Biaxial Biomechanical Behavior of Human Abdominal Aorta

Author(s):  
Jonathan P. Vande Geest ◽  
Michael S. Sacks ◽  
David A. Vorp

The biomechanical response of abdominal aortic tissue to uniaxial loading conditions has been reported previously [1]. This testing identified the uniaxial mechanical response of aortic tissue to specimens oriented in the longitudinal and circumferential directions, but did not provide significant evidence for the isotropy or anisotropy of this tissue. The information taken from uniaxial tensile testing is insufficient for the characterization of the multi-axial mechanical response of aortic tissue. In particular, the uniaxial response of a biological tissue in a given direction does not incorporate the effects of loading in an orthogonal direction. For these reasons, there exists a need for an enhanced description of the mechanical response of aortic tissue to loading in multiple planar directions. For the current investigation, biaxial tensile testing was performed on normal abdominal aortic tissue in order to gain insight into the anisotropy and age related differences of the biomechanical response of this tissue.

Author(s):  
J. Ferruzzi ◽  
M. S. Enevoldsen ◽  
J. D. Humphrey

Abdominal aortic aneurysm (AAA) is a pathological condition of the infrarenal aorta characterized by a local dilatation of the arterial wall. The main histopathologic features of an AAA are smooth muscle cell death and loss of elastin. The biomechanical behavior of AAAs has been widely studied to determine the rupture potential according to the principles of material failure. However, most prior approaches are limited by the use of data from uniaxial tensile testing and by the assumption of material isotropy, leading to inaccurate characterization of the 3D multiaxial mechanical response of the aneurysmal tissue. To date, the best data available on the behavior of human abdominal aorta (AA) and AAA to planar biaxial testing are the ones reported by Vande Geest et al. [1,2]. In a recent work [3], we considered a structurally motivated four-fiber family strain energy function (SEF) [4] to capture the biaxial behavior of the human AA and AAA from Vande Geest et al. [1,2]. We showed that this constitutive relation fits human data better than prior models and most importantly it captures the stiffening of the arterial wall related to both aging and aneurysmal development. These changes in mechanical behavior are mirrored by changes in the best-fit values of the parameters, with a progressive decrease of the isotropic part attributed to elastin and a parallel increase in values associated with the families of collagen fibers.


2002 ◽  
Vol 62 (1) ◽  
pp. 73-81 ◽  
Author(s):  
J. M. García Páez ◽  
A. Carrera ◽  
E. Jorge Herrero ◽  
I. Millán ◽  
A. Rocha ◽  
...  

2001 ◽  
Author(s):  
M. A. Haque ◽  
M. T. A. Saif

Abstract We present a MEMS-based technique for in-situ uniaxial tensile testing of freestanding thin films inside SEM and TEM. It integrates a freestanding thin film specimen with MEMS force sensors and structures to produce an on-chip tensile testing facility. Cofabrication of the specimen with force and displacement measuring mechanisms produces the following unique features: 1) Quantitative experimentation can be carried out in both SEM and TEM, 2) No extra gripping mechanism is required, 3) Specimen misalignment can be eliminated, 4) Pre-stress in specimen can be determined, and 5) Specimens with micrometer to nanometer thickness can be tested. We demonstrate the technique by testing a 200-nanometer thick Aluminum specimen in-situ in SEM. Significant strengthening and anelasticity were observed at this size scale.


2000 ◽  
Author(s):  
T. Jesse Lim ◽  
Wei-Yang Lu

Abstract In this work, uniaxial tensile testing of a 63Sn-37Pb alloy with different specimen sizes and aging conditions had been carried out. Although the stress-strain responses of different specimen sizes and aging conditions differs, the ultimate strength of the specimens with 16 hours, 100°C aging are similar for the sizes tested. The specimens with 25 days, 100°C aging have different stress-strain response with different sizes, and have a lower ultimate strength and higher failure strain compared to 16 hours, 100°C aging specimens.


2019 ◽  
Vol 180 ◽  
pp. 107962
Author(s):  
Haichao Gong ◽  
Qunbo Fan ◽  
Yu Zhou ◽  
Duoduo Wang ◽  
Pengru Li ◽  
...  

2000 ◽  
Vol 1723 (1) ◽  
pp. 125-132 ◽  
Author(s):  
Ghassan R. Chehab ◽  
Emily O’Quinn ◽  
Y. Richard Kim

Reliable materials characterization and performance prediction testing of asphalt concrete requires specimens that can be treated as statistically homogeneous and representative of the material being tested. The objective of this study was to select a proper specimen geometry that could be used for uniaxial tensile testing. Selection was based on the variation of air void content along the height of specimens cut and cored from specimens compacted by the Superpave gyratory compactor (SGC) and on the representative behavior under mechanical testing. From measurement and comparison of air void contents in cut and cored specimens, it was observed for several geometries that sections at the top and bottom and those adjacent to the mold walls have a higher air void content than do those in the middle. It is thus imperative that test specimens be cut and cored from larger-size SGC specimens. Complex modulus and constant crosshead-rate monotonic tests were conducted for four geometries—75 × 115, 75 × 150, 100 × 150, and 100 × 200 mm—to study the effect of geometry boundary conditions on responses. On the basis of graphical and statistical analysis, it was determined that there was an effect on the dynamic modulus at certain frequencies but no effect on the phase angle. Except for 75 × 115 mm, all geometries behaved similarly under the monotonic test. From these findings and other considerations, it is recommended that the 75- × 150-mm geometry, which is more conservative, and the 100- × 150-mm geometry be used for tensile testing.


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