Chemotherapy Drug Encapsulated Poly(Lactic-Co-Glycolic Acid) Nanoparticles

2006 ◽  
Author(s):  
A. Champa Jayasuriya ◽  
Anthony Darr ◽  
Nabil A. Ebraheim
Keyword(s):  
Adverse Effects ◽  
Glycolic Acid ◽  
Bone Cancer ◽  
High Dose Chemotherapy ◽  
Plga Nanoparticles ◽  
Cancer Site ◽  
High Dose ◽  
Chemotherapy Drug ◽  
Chemotherapy Drugs

In order to exhibit pharmacological activity at the bone cancer site, high-dose chemotherapy drugs need to be used. This often causes toxicity and unfavorable systemic adverse effects leading to significant problems to the patient. Since nanoparticles are in subcellular size, they can effectively entered to the cell membrane that could result in higher cellular uptake. In this study, we report preparation and characterization of poly(lactic-co-glycolic acid) - PLGA nanoparticles, which encapsulated with chemotherapy drug cisplatin.

How I treat elderly patients with myeloma

Blood ◽  
2010 ◽  
Vol 116 (13) ◽  
pp. 2215-2223 ◽  
Author(s):  
Jayesh Mehta ◽  
Michele Cavo ◽  
Seema Singhal
Keyword(s):  
Adverse Effects ◽  
Older Patients ◽  
Supportive Therapy ◽  
The Elderly ◽  
High Dose Chemotherapy ◽  
Cytotoxic Agents ◽  
High Dose ◽  
Clinical Approach ◽  
Younger Patients ◽  
Best Response

Abstract The clinical approach to older patients with myeloma has to be modified to take into account comorbidities and the likelihood of higher treatment-related toxicity. Individualization of management and adequate supportive therapy are important to obtain the best response while minimizing adverse effects. Corticosteroids, novel agents, conventional cytotoxic agents, and high-dose chemotherapy with autotransplantation (modalities used in younger patients) are also used in older patients, although the elderly undergo transplantation less frequently. The sequential use of active agents singly and in different combinations has improved response rates and survival of all patients with myeloma, including the elderly.

Leakage Radiometric Control of Chemical Drugs with Regional Perfusion of Surgical Isolated Limbs

2019 ◽  
pp. 32-38
Author(s):  
Б. Наркевич ◽  
B. Narkevich ◽  
С. Ширяев ◽  
S. Shiryaev ◽  
И. Лагутина ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Clinical Effectiveness ◽  
High Dose Chemotherapy ◽  
Regional Perfusion ◽  
High Dose ◽  
Inhalation Anesthesia ◽  
Chemotherapy Drug ◽  
Upper And Lower Extremities ◽  
99Mtc Activity

Purpose: Modernization and evaluation of the clinical effectiveness of the technology of continuous radiometric monitoring carried out during high-dose chemotherapy of a surgically isolated limb with tumor foci. Material and methods: A modernized radiometric control technology for regional limb perfusion is proposed. It is based on in vivo labeling of erythrocytes with 99mTc eluate followed by continuous monitoring of the activity of labeled erythrocytes as a simulator of a chemotherapy drug over the heart region. Its distinctive features are intravenous injection of a pyrfotech slice after giving inhalation anesthesia to ensure a sufficient level of red blood cell chelation, as well as using 99mTc activity less than its minimum significant level, which allows working with an open source of ionizing radiation without violating the requirements of radiation safety regulations. Results: The developed technology was successfully used with 106 regional perfusion of the upper and lower extremities in patients with melanoma or sarcoma of soft tissues. In 4 cases, according to the results of radiometric control, the intervention of the surgical team was required to reduce the chemical preparation leakage that was occurring. Conclusion: The technology upgraded by us is characterized by ease of implementation, the ability to take timely measures to prevent or reduce the leakage of a chemotherapy drug from an isolated limb according to the results of continuous in vivo radiometric monitoring of 99mTc-labeled red blood cells over the heart, as well as low radiation load on the patient and staff.

scholarly journals Analysis and comparison of metal-doped on Graphene-Genistein using QM/MM calculations

2021 ◽  
Author(s):  
Afshar Alihosseini ◽  
Marziyeh Choupani ◽  
Majid Monajjemi ◽  
Hossein Sakhaeinia
Keyword(s):  
Density Functional ◽  
Density Functional Theory Calculation ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Chemotherapy Drugs ◽  
Receptor Modulator ◽  
Doped Graphene ◽  
Homo And Lumo ◽  
Metal Doped ◽  
Theory Calculation

Genistein (5,7,4′-trihydroxyisoflavone) is an isoflavone abundantly found in soy and other legumes and acts as a selective estrogen receptor modulator (SERM). When testing for similar abilities among other flavonoids, it has been found to be a strong topoisomerase inhibitor. Similar to some high-dose chemotherapy drugs, it was strongly toxic to normal cells. In this study, the adsorption of genistein on the surface of exclusive graphene and Ni, Ti, Cr, and Se-doped graphene was theoretically evaluated by means of density functional theory calculation. Initially, we varied the position of genistein from the surface of pristine and decorated graphene by changing the distances between (1-5 Å) and gained the Ead and Egap for each situation. Our calculation indicated that adsorption energies (Ead) of pristine genistein to graphene with Ni decorated graphene, Ti-     decorated graphene, and Cr-decorated graphene and Se-decorated graphene are: 954.984, 318.168, 797.480, 946.725, 958.154 kcal/mole, respectively, and the calculated values of adsorption energy in the equilibrium distance (de=3.918OA.) of genistein to Ni-decorated graphene reveal that apparently genistein- Ni-decorated graphene as the most energetically favorable position was correctly selected in comparison with other atom     -decorated graphene. In consequence, we explain the density of states (Doss) and frontier molecular orbitals HOMO and LUMO for Ni-decorated graphene and complexes with genistein; therefore, data confirmed that a positive charge of Ni-decorated graphene for nucleophile molecules could be achieved. 

scholarly journals Clinical, Pathological, and Molecular Characterization of Infant Medulloblastomas Treated with Sequential High-Dose Chemotherapy

2016 ◽  
Vol 63 (9) ◽  
pp. 1527-1534 ◽  
Author(s):  
Lucie Lafay-Cousin ◽  
Amy Smith ◽  
Susan N. Chi ◽  
Elizabeth Wells ◽  
Jennifer Madden ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
High Dose Chemotherapy ◽  
High Dose

Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles

Soft Matter ◽  
2018 ◽  
Vol 14 (40) ◽  
pp. 8090-8094 ◽  
Author(s):  
Jie Yang ◽  
Ruo-Nan Zhang ◽  
Dong-Jie Liu ◽  
Xu Zhou ◽  
Tatsuya Shoji ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Spectroscopic Characterization ◽  
Plga Nanoparticles ◽  
Laser Trapping ◽  
Poly Ethylene Glycol ◽  
Chemical Methods ◽  
Raman Spectroscopic ◽  
Confocal Raman ◽  
Poly Ethylene

We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic-co-glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e., SOCl2 halogenate-alcoholysis and DCC dehydration. The PEG-immobilized PLGA nanoparticles were precisely characterized by the laser trapping/confocal Raman spectroscope.

Sign in / Sign up

Export Citation Format

Share Document