3D Core-Shell Simulation of Hydrogel Swelling Behavior for Controlled Drug Delivery

2013 ◽  
Author(s):  
Jilong Wang ◽  
Jenny Qiu ◽  
Shiren Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Heat Equation ◽  
Temperature Change ◽  
Three Dimensional ◽  
Controlled Drug Delivery ◽  
Swelling Behavior ◽  
Core Shell ◽  
Polyelectrolyte Gels ◽  
Hydrogel Swelling

In this paper, a three-dimensional dynamic model describing drug delivery and swelling behavior of polyelectrolyte gels was developed based on the Maxwell-Stefan equation and Bio-heat equation. COMSOL software was employed to simulate hydrogel swelling and the transportation of created automatically by COMSOL, and it had 78035 elements, which was unconcerned with the results. The results showed that Maxwell-Stefan equation and Bio-heat equation were suitable for modeling hydrogel behavior of swelling with temperature change. In addition, when temperature increased, the hydrogel swelling increased which also intensified drug release.

Water based PHEMA hydrogels for controlled drug delivery

2017 ◽  
Vol 43 (3) ◽  
pp. 228-239
Author(s):  
Hakan Ayhan ◽  
Fatma Ayhan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Bacterial Strains ◽  
Buffer Solutions ◽  
Free Radical Photopolymerization ◽  
Water Based ◽  
Hydrogel Swelling ◽  
Drug Activities

Abstract Objective: In the scope of presented work, synthesis of water based acrylate hydrogels, characterization, and their usage in controlled drug release systems were aimed to investigate. Methods: Synthesis of acrylate based hydrogels that have different properties was carried out by free radical photopolymerization using photoinitiator. Because of its high biocompatibility, 2-hydroxyethyl metacrylate (HEMA) was used as monomer. Then drug release experiments were performed in pH 7.4 and 1.2 buffer solutions with certain ionic strength while the dynamic swelling behaviors were also determined. In the last part of the work, drug activities of synthesized drug-loaded hydrogels were tested in mediums containing Staphylococcus aureus and Pseudomonas aeruginosa bacteria cultures. Results: ATR-FTIR spectrums of all synthesized hydrogels were analyzed. The characteristic O-H, C-H, C=O, C-O tension vibrations bands were observed in the spectrums of the hydrogels. The rate of drug release in acidic pH 1.2 for two types of hydrogels was observed to be much faster than at pH 7.4. It was determined that hydrogel swelling ratio decrease with increasing monomer ratio. All drug loaded hydrogels were effective to inhibit the growth of both two bacterial strains. Conclusion: Hydrogels synthesized were found to be suitable for the controlled drug delivery applications.

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

Evaluation of clay-ionene nanocomposite carriers for controlled drug delivery: Synthesis, in vitro drug release, and kinetics

2019 ◽  
Vol 225 ◽  
pp. 122-132 ◽  
Author(s):  
Hany El-Hamshary ◽  
Mohamed H. El-Newehy ◽  
Meera Moydeen Abdulhameed ◽  
Ayman El-Faham ◽  
Abeer S. Elsherbiny
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
In Vitro Drug Release

A pH-responsive amphiphilic chitosan–pyranine core–shell nanoparticle for controlled drug delivery, imaging and intracellular pH measurement

2014 ◽  
Vol 2 (38) ◽  
pp. 6580-6589 ◽  
Author(s):  
Hao-Syun Chou ◽  
Meng-Hsuan Hsiao ◽  
Wei-Yang Hung ◽  
Tin-Yo Yen ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Ph ◽  
Controlled Drug Delivery ◽  
Ph Measurement ◽  
Core Shell ◽  
Ph Responsive ◽  
Cellular Resolution ◽  
New Type

A new type of CHC–PY core–shell nanoparticle provides multiple functionality, where a synergistic performance of nanotherapeutics, imaging and even diagnosis at a cellular resolution can be achieved simultaneously.

Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

2020 ◽  
Vol 44 (17) ◽  
pp. 7175-7185 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Subha Balakrishnan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T. S. N. ◽  
Muthukrishnan Lakshmipathy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Gum Acacia ◽  
Shell Type

In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.

Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

2014 ◽  
Vol 5 (10) ◽  
pp. 3311-3315 ◽  
Author(s):  
Alexander E. Dunn ◽  
Douglas J. Dunn ◽  
Alexander Macmillan ◽  
Renee Whan ◽  
Tim Stait-Gardner ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Alternating Magnetic Field ◽  
Temporal Control ◽  
Delivery Platform

A novel theranostic controlled drug delivery platform that binds the drug to the nanocarrier by utilising Schiff base bonds to achieve high spatial and temporal control over drug release.

PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (8) ◽  
pp. 1627-1634 ◽  
Author(s):  
Juliana M. Chan ◽  
Liangfang Zhang ◽  
Kai P. Yuet ◽  
Grace Liao ◽  
June-Wha Rhee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Comparison of chitosan microsphere versus O-carboxymethyl chitosan microsphere for drug delivery systems

2017 ◽  
Vol 32 (5) ◽  
pp. 469-486 ◽  
Author(s):  
Gang Zhou ◽  
Jing Zhang ◽  
Jun Tai ◽  
Qianyi Han ◽  
Lei Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Carboxymethyl Chitosan ◽  
Cross Linking ◽  
Chitosan Microspheres ◽  
Chitosan Microsphere

The development of controlled drug delivery systems for bone regeneration, especially microspheres, has become a research hotspot in recent years. Chitosan and its derivative O-carboxymethyl chitosan have been considered to be an effective way for controlled drug delivery due to their nontoxicity and biodegradability. Currently, most of the studies have researched on synthesizing and characterizing chitosan and O-carboxymethyl chitosan. However, few studies have focused on the differences between chitosan microspheres and O-carboxymethyl chitosan microspheres directly. In this study, chitosan and O-carboxymethyl chitosan microspheres were developed by water-in-oil emulsification cross-linking method using vanillin as the cross-linking agent, and then their physicochemical properties were evaluated by Fourier transform infrared spectroscopy, scanning electron microscopy, and in vitro release testing. The results showed that O-carboxymethyl chitosan was successfully modified by adding carboxymethyl group at the chitosan C6 position.The particle size of chitosan microspheres (50–90 µm) was significantly larger than that of O-carboxymethyl chitosan microspheres (10–50 µm), and the drug release profile of O-carboxymethyl chitosan microspheres showed larger initial burst release within the first day and sustained release at the fourth day, while chitosan microspheres showed sustained release at the seventh day. In addition, Cell Counting Kit-8 assay showed that MC3T3-E1 proliferated well and highly expressed the alkaline phosphatase marker protein on both chitosan and O-carboxymethyl chitosan microspheres. Overall, both chitosan and O-carboxymethyl chitosan microspheres showed good biocompatibility, and chitosan microspheres were superior to O-carboxymethyl chitosan microspheres. Moreover, the different drug release rates suggest that chitosan and O-carboxymethyl chitosan microspheres have the potential to be used for the repair of different bone defects.

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