Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

2020 ◽  
Vol 44 (17) ◽  
pp. 7175-7185 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Subha Balakrishnan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T. S. N. ◽  
Muthukrishnan Lakshmipathy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Gum Acacia ◽  
Shell Type

In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.

A pH-responsive amphiphilic chitosan–pyranine core–shell nanoparticle for controlled drug delivery, imaging and intracellular pH measurement

2014 ◽  
Vol 2 (38) ◽  
pp. 6580-6589 ◽  
Author(s):  
Hao-Syun Chou ◽  
Meng-Hsuan Hsiao ◽  
Wei-Yang Hung ◽  
Tin-Yo Yen ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Ph ◽  
Controlled Drug Delivery ◽  
Ph Measurement ◽  
Core Shell ◽  
Ph Responsive ◽  
Cellular Resolution ◽  
New Type

A new type of CHC–PY core–shell nanoparticle provides multiple functionality, where a synergistic performance of nanotherapeutics, imaging and even diagnosis at a cellular resolution can be achieved simultaneously.

New core-shell hydroxyapatite/Gum-Acacia nanocomposites for drug delivery and tissue engineering applications

2018 ◽  
Vol 92 ◽  
pp. 685-693 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T.S. Nellaiappan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Engineering Applications ◽  
Gum Acacia

In Situ Generation of Polyaniline inside Zeolite Pores for Retention of Ions and for Controlled Drug Delivery

2013 ◽  
Vol 583 ◽  
pp. 91-94 ◽  
Author(s):  
Aurelia Cristina Nechifor ◽  
Alexandrina Ivan ◽  
Stefan Ioan Voicu ◽  
Valeriu Danciulescu ◽  
Roxana Trusca
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Sodium Vanadate ◽  
Biological Interest

In order to improve the capabilities of zeolites for biomedical applications, new composite materials based on polyaniline in-situ generated inside zeolite pores were developed. As precursors for polyaniline several monomers (like aniline and p-phnylenediamine) were used and different oxidant systems (like ammonium peroxodisulphate/HCl, sodium vanadate/ethylic alcohol) were studied and were used for the separation of different biological interest ions and release of antibiotics.

PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (8) ◽  
pp. 1627-1634 ◽  
Author(s):  
Juliana M. Chan ◽  
Liangfang Zhang ◽  
Kai P. Yuet ◽  
Grace Liao ◽  
June-Wha Rhee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3404 ◽  
Author(s):  
Bartłomiej Kost ◽  
Marek Brzeziński ◽  
Marta Socka ◽  
Małgorzata Baśko ◽  
Tadeusz Biela
Keyword(s):  
Drug Delivery ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Natural Polymers ◽  
Supramolecular Systems ◽  
Aliphatic Polyesters ◽  
Different Types ◽  
Functional Biomaterials ◽  
Synthetic And Natural Polymers

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

Biogenic Synthesis of Gold Nanoparticles and Their Antimicrobial Activities

2020 ◽  
pp. 216-233
Author(s):  
Snežana Radisavljević ◽  
Biljana Petrović
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Food Packaging ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Bactericidal Effect ◽  
Antimicrobial Activities ◽  
Physiochemical Properties

Gold nanoparticles (AuNPs) are widely used in biomedical applications, especially diagnostic and drug delivery. The antibacterial activity of nanoparticles depends on the dimensions of the particles. AuNPs may associate with the surface of the cell membrane and cause disorder such as respiration and permeability. The method of binding of particles for bacteria depends on their surface available for interaction. Smaller particles which have the larger surface area available for interaction will show better bactericidal effect than the larger particles. Useful antibacterial agents should also be toxic to various pathogenic bacteria with the ability to coat different surfaces like biomaterials, devices, textiles, food packaging, and so on. The biological and physiochemical properties of synthesized AuNPs have impact on the use of gold nanoparticles like antimicrobial agents, especially for water purification, as well as other biomedical applications.

scholarly journals Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3383 ◽  
Author(s):  
Jie Zhu ◽  
Hua Han ◽  
Ting-Ting Ye ◽  
Fa-Xue Li ◽  
Xue-Li Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Hybrid Hydrogel ◽  
Antibacterial Studies ◽  
Hybrid Hydrogels ◽  
Stimuli Sensitive

The stimuli-sensitive and biodegradable hydrogels are promising biomaterials as controlled drug delivery systems for diverse biomedical applications. In this study, we construct hybrid hydrogels combined with peptide-based bis-acrylate and acrylic acid (AAc). The peptide-based bis-acrylate/AAc hybrid hydrogel displays an interconnected and porous structure by scanning electron microscopy (SEM) observation and exhibits pH-dependent swelling property. The biodegradation of hybrid hydrogels was characterized by SEM and weight loss, and the results showed the hydrogels have a good enzymatic biodegradation property. The mechanical and cytotoxicity properties of the hydrogels were also tested. Besides, triclosan was preloaded during the hydrogel formation for drug release and antibacterial studies. In summary, the peptide-based bis-acrylate/AAc hydrogel with stimuli sensitivity and biodegradable property may be excellent candidates as drug delivery systems for antibacterial wound dressing application.

Sign in / Sign up

Export Citation Format

Share Document