Investigation of the Functional Properties of Additively-Fabricated Triply Periodic Minimal Surface-Based Bone Scaffolds for the Treatment of Osseous Fractures

Author(s):  
Abigail Chaffins ◽  
Mohan Yu ◽  
Pier Paolo Claudio ◽  
James B. Day ◽  
Roozbeh (Ross) Salary

Abstract Fused deposition modeling (FDM), is a direct-write material extrusion additive manufacturing process, which has emerged as a method of choice for the fabrication of a wide range of biological tissues and structures. FDM allows for non-contact, multi-material deposition of a broad spectrum of functional materials for tissue engineering applications. However, the FDM process is intrinsically complex, consisting of a multitude of parameters as well as material-machine interactions, which may adversely influence the mechanical properties, the surface morphology, and ultimately the functional integrity of fabricated bone scaffolds. Hence, process optimization in addition to physics-based characterization of the FDM process would be inevitably a need. The overarching goal of this research work is to fabricate biocompatible, porous bone scaffolds, incorporating autologous human bone marrow mesenchymal stem cells (hBMSCs), for the treatment of osseous fractures, defects, and eventually diseases. The objective of this work is to investigate the mechanical properties of several triply periodic minimal surface (TPMS) bone scaffolds, fabricated using fused deposition modeling (FDM) additive manufacturing process. In this study, biocompatible TPMS bone scaffolds were FDM-deposited, based on a medical-grade polymer composite, composed of polyamide, polyolefin, and cellulose fibers (named PAPC-II). In addition, the experimental characterization of the TPMS bone scaffolds was on the basis of a single factor experiment. The compression properties of the fabricated bone scaffolds were measured using a compression testing machine. Furthermore, a digital image processing program was developed in the MATLAB environment to characterize the morphological properties of the fabricated bone scaffolds.

2020 ◽  
Vol 13 (1) ◽  
pp. 181-186
Author(s):  
N. Nandakumar ◽  
T.Allwin Raja

This project is related to the design, fabrication and characterization of scaffold structures of different structure Using Polylactic Acid (PLA) filament, the micro bone structures are manufactured by Fused Deposition Modeling (FDM). Such morphology is chosen for its good strength, high porosity leading to good nutrient and waste diffusion, and favorable mechanical properties. Load vs Displacement values are obtained by taking compression tests for each as an overall outcome of the research, microstructure with better mechanical properties to replace the damaged bone tissues is identified.


Author(s):  
Arash Alex Mazhari ◽  
Randall Ticknor ◽  
Sean Swei ◽  
Stanley Krzesniak ◽  
Mircea Teodorescu

AbstractThe sensitivity of additive manufacturing (AM) to the variability of feedstock quality, machine calibration, and accuracy drives the need for frequent characterization of fabricated objects for a robust material process. The constant testing is fiscally and logistically intensive, often requiring coupons that are manufactured and tested in independent facilities. As a step toward integrating testing and characterization into the AM process while reducing cost, we propose the automated testing and characterization of AM (ATCAM). ATCAM is configured for fused deposition modeling (FDM) and introduces the concept of dynamic coupons to generate large quantities of basic AM samples. An in situ actuator is printed on the build surface to deploy coupons through impact, which is sensed by a load cell system utilizing machine learning (ML) to correlate AM data. We test ATCAM’s ability to distinguish the quality of three PLA feedstock at differing price points by generating and comparing 3000 dynamic coupons in 10 repetitions of 100 coupon cycles per material. ATCAM correlated the quality of each feedstock and visualized fatigue of in situ actuators over each testing cycle. Three ML algorithms were then compared, with Gradient Boost regression demonstrating a 71% correlation of dynamic coupons to their parent feedstock and provided confidence for the quality of AM data ATCAM generates.


2021 ◽  
Vol 6 (2) ◽  
pp. 119
Author(s):  
Nanang Ali Sutisna ◽  
Rakha Amrillah Fattah

The method of producing items through synchronously depositing material level by level, based on 3D digital models, is named Additive Manufacturing (AM) or 3D-printing. Amongs many AM methods, the Fused Deposition Modeling (FDM) technique along with PLA (Polylactic acid) material is commonly used in additive manufacturing. Until now, the mechanical properties of the AM components could not be calculated or estimated until they've been assembled and checked. In this work, a novel approach is suggested as to how the extrusion process affects the mechanical properties of the printed component to obtain how the parts can be manufactured or printed to achieve improved mechanical properties. This methodology is based on an experimental procedure in which the combination of parameters to achieve an optimal from a manufacturing experiment and its value can be determined, the results obtained show the effect of the extrusion process affects the mechanical properties.


Author(s):  
Pravin R. Kubade ◽  
Hrushikesh B. Kulkarni ◽  
Vinayak C. Gavali

Additive Manufacturing or three-dimensional printing refers to a process of building lighter, stronger three-dimensional parts, manufactured layer by layer. Additive manufacturing uses a computer and CAD software which passes the program to the printer to build the desired shape. Metals, thermoplastic polymers, and ceramics are the preferred materials used for additive manufacturing. Fused deposition modeling is one additive manufacturing technique involving the use of thermoplastic polymer for creating desired shape. Carbon fibers can be added into polymer to strengthen the composite without adding additional weight. Present work deals with the manufacturing of Carbon fiber-reinforced Polylactic Acid composites prepared using fused deposition modeling. Mechanical and thermo-mechanical properties of composites are studied as per ASTM standards and using sophisticated instruments. It is observed that there is enhancement in thermo-mechanical properties of composites due to addition reinforcement which is discussed in detail.


2016 ◽  
Vol 22 (2) ◽  
pp. 387-404 ◽  
Author(s):  
Jonathan Torres ◽  
Matthew Cole ◽  
Allen Owji ◽  
Zachary DeMastry ◽  
Ali P. Gordon

Purpose This paper aims to present the influences of several production variables on the mechanical properties of specimens manufactured using fused deposition modeling (FDM) with polylactic acid (PLA) as a media and relate the practical and experimental implications of these as related to stiffness, strength, ductility and generalized loading. Design/methodology/approach A two-factor-level Taguchi test matrix was defined to allow streamlined mechanical testing of several different fabrication settings using a reduced array of experiments. Specimens were manufactured and tested according to ASTM E8/D638 and E399/D5045 standards for tensile and fracture testing. After initial analysis of mechanical properties derived from mechanical tests, analysis of variance was used to infer optimized production variables for general use and for application/load-specific instances. Findings Production variables are determined to yield optimized mechanical properties under tensile and fracture-type loading as related to orientation of loading and fabrication. Practical implications The relation of production variables and their interactions and the manner in which they influence mechanical properties provide insight to the feasibility of using FDM for rapid manufacturing of components for experimental, commercial or consumer-level use. Originality/value This paper is the first report of research on the characterization of the mechanical properties of PLA coupons manufactured using FDM by the Taguchi method. The investigation is relevant both in commercial and consumer-level aspects, given both the currently increasing utilization of 3D printers for component production and the viability of PLA as a renewable, biocompatible material for use in structural applications.


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