Enhancement in Treatment Planning for Magnetic Nanoparticle Hyperthermia: Optimization of the Heat Absorption Pattern

2009 ◽  
Author(s):  
Maher Salloum ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Relaxation Mechanism ◽  
Field Frequency ◽  
Nanoparticle Distribution ◽  
Injection Parameters ◽  
Absorption Pattern ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Heating Pattern ◽  
Low Magnetic Field

Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude [1]. The heat generated by the particles under the application of an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles [2]. In clinical applications, it is very important to ensure a maximum damage to the tumor while protecting the normal tissue. The resulted heating pattern by the nanoparticle distribution in tumor is closely related to the injection parameters [3, 4].

An In-Vivo Experimental Study of Temperature Elevations in Animal Tissue During Magnetic Nanoparticle Hyperthermia

2008 ◽  
Author(s):  
Maher Salloum ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Relaxation Mechanism ◽  
Field Frequency ◽  
Small Magnetic Field ◽  
Magnetite Fe3o4 ◽  
Therapeutic Results ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Low Magnetic Field

Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude [1]. Iron oxides magnetite Fe3O4 and maghemite γ-Fe2O3 nanoparticles are the most studied to date [2] due to their biocompatibilty [3] for hyperthermia application. The heat generated by the particles when exposed to an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles [4]. The superparamagnetic particles (10–40 nm) are recommended in clinical application as they are able to generate substantial heat within a small magnetic field strength and frequency [5].

Temperature Elevations in Implanted Prostatic Tumors in Mice During Magnetic Nanoparticle Hyperthermia: In Vivo Experimental Study

2011 ◽  
Author(s):  
Anilchandra Attaluri ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Field ◽  
Infusion Rate ◽  
Magnetic Nanoparticle ◽  
Animal Experiments ◽  
Intratumoral Injection ◽  
Temperature Elevation ◽  
Nanoparticle Distribution ◽  
Slow Infusion ◽  
Magnetic Nanoparticle Hyperthermia

In this study, we perform in vivo animal experiments on implanted prostatic tumors in mice to measure temperature elevation distribution in the tumor during magnetic nanoparticle hyperthermia. Temperature rises are induced by a commercially available ferrofluid injected to the center of the tumor, which is subject to an alternating magnetic field. Temperature mapping in the implanted prostatic tumors during the heating has illustrated the feasibility of elevating the tumor temperature higher than 50°C using only 0.1 cc ferrofluid injected in the tumor and under a relatively low magnetic field (3 kA/m). Ferrofluid infusion rates during intratumoral injection may affect nanoparticle spreading in tumors. Using a very slow infusion rate of 5 μ1/min results in an average temperature elevation in tumors 27°C above the baseline temperatures of 37°C. However, the temperature elevations are barely 14°C when the infusion rate is 20 μl/min. Our results suggest a more confined nanoparticle distribution to the injection site using smaller infusion rates.

scholarly journals Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Nanoparticles: AnIn VitroStudy

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Asahi Tomitaka ◽  
Tsutomu Yamada ◽  
Yasushi Takemura
Keyword(s):  
Magnetic Field ◽  
Temperature Rise ◽  
Hela Cells ◽  
Cytotoxic Effect ◽  
Magnetic Nanoparticle ◽  
Hyperthermia Treatment ◽  
Coated Nanoparticles ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Induced Apoptosis

Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, andin vitrohyperthermia effect of nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.

scholarly journals Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

2015 ◽  
Vol 08 (02) ◽  
pp. 1550008 ◽  
Author(s):  
Yangyang Liu ◽  
Zhiyu Qian ◽  
Jianhua Yin ◽  
Xiao Wang
Keyword(s):  
Magnetic Field ◽  
Tumor Cells ◽  
Magnetic Nanoparticle ◽  
Tumor Therapy ◽  
Low Frequency ◽  
Alternating Magnetic Field ◽  
Nanoparticle Concentration ◽  
Field Frequency ◽  
A New Technique ◽  
The Magnetic Field

Magnetic nanoparticle plays an important role in biomedical engineering, especially in tumor therapy. In this paper, a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-frequency alternating magnetic field (LFAMF) to kill tumor cells. The LFAMF system which was used to drive magnetic nanoparticles (MNPs) was setup with the magnetic field frequency and power range at ∼ 10–100 Hz and ∼ 10–200 mT, respectively. During the experiment, the LFAMF was adjusted at different frequencies and power levels. The experimental results show that the liver tumor cells (HepG2) mixed with MNPs (10 μg/mL) became partial fragments when exposed in the LFAMF with different frequencies (∼ 10–100 Hz) and power (∼ 10–200 mT), and the higher the frequency or the power, the more the tumor cells were killed at the same magnetic nanoparticle concentration. Conclusion: Tumor cells were effectively damaged by MNPs under LFAMF, which suggests that they had great potential to be applied in tumor therapy.

Numerical Study of Nanofluid Transport in Tumors During Nanofluid Infusion for Magnetic Nanoparticle Hyperthermia Treatment

2012 ◽  
Author(s):  
Di Su ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Nanoparticle ◽  
Numerical Study ◽  
Critical Role ◽  
Oxide Nanoparticles ◽  
Temperature Elevation ◽  
Hyperthermia Treatment ◽  
Nanoparticle Distribution ◽  
Lack Of Control ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Transport In Tumors

The application of nanostructures in hyperthermia treatment of cancer has attracted growing research interest due to the fact that magnetic nanoparticles are able to generate impressive levels of heat when excited by an external magnetic field [1–3]. Various types of nanoparticles such as magnetite and superparamagentic iron oxide nanoparticles have demonstrated great potentials in hyperthermia treatment; however many challenges need to be addressed for future applications of this method in clinical studies. One leading issue is the limited knowledge of nanoparticle distribution in tumors. Since the temperature elevation is induced as the result of the heat generation by the nanoparticles, the concentration distributions of the particles in a tumor play a critical role in determining the efficacy of the treatment. The lack of control of the nanoparticle distribution may lead to inadequacy in killing tumor cells and/or damage to the healthy tissue.

scholarly journals MAGNETIC NANOPARTICLE HYPERTHERMIA IN CANCER TREATMENT

Nano LIFE ◽  
2010 ◽  
Vol 01 (01n02) ◽  
pp. 17-32 ◽  
Author(s):  
ANDREW J. GIUSTINI ◽  
ALICIA A. PETRYK ◽  
SHIRAZ M. CASSIM ◽  
JENNIFER A. TATE ◽  
IAN BAKER ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Radiation Therapy ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Magnetic Nanoparticle ◽  
Materials Science ◽  
Tumor Site ◽  
Conventional Chemotherapy ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Ferromagnetic Particles

The activation of magnetic nanoparticles (mNPs) by an alternating magnetic field (AMF) is currently being explored as technique for targeted therapeutic heating of tumors. Various types of superparamagnetic and ferromagnetic particles, with different coatings and targeting agents, allow for tumor site and type specificity. Magnetic nanoparticle hyperthermia is also being studied as an adjuvant to conventional chemotherapy and radiation therapy. This review provides an introduction to some of the relevant biology and materials science involved in the technical development and current and future use of mNP hyperthermia as clinical cancer therapy.

Magnetic Nanoparticle Hyperthermia Cancer Therapy Temperature Distribution Modeling and Validation

2013 ◽  
Author(s):  
Robert V. Stigliano ◽  
Fridon Shubitidze ◽  
P. Jack Hoopes
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Strong Influence ◽  
Magnetic Interaction ◽  
Tumor Site ◽  
The Past ◽  
Distribution Modeling ◽  
Hyperthermia Therapy ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Tumor Types

The use of magnetic nanoparticles (mNP’s) in hyperthermia therapy for the treatment of cancer has been receiving increasing interest in the past few decades. It is known that heating cancerous tissues to temperatures above physiologically normal levels will cause cytotoxicity. In mNP hyperthermia, mNP’s are either injected intravenously or directly into the tumor site. In many tumor types the nanoparticles are invaginated into the cancer cells and aggregated into endosomes. Local temperature increases are achievable by exposing tumors containing mNP’s to an alternating magnetic field (AMF). The proximity of the mNP’s has a strong influence on their ability to generate heat due to inter-particle magnetic interaction effects [1, 2]. Taking this effect into account is important when modeling the heating characteristics of mNP’s.

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