scholarly journals MAGNETIC NANOPARTICLE HYPERTHERMIA IN CANCER TREATMENT

Nano LIFE ◽  
2010 ◽  
Vol 01 (01n02) ◽  
pp. 17-32 ◽  
Author(s):  
ANDREW J. GIUSTINI ◽  
ALICIA A. PETRYK ◽  
SHIRAZ M. CASSIM ◽  
JENNIFER A. TATE ◽  
IAN BAKER ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Radiation Therapy ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Magnetic Nanoparticle ◽  
Materials Science ◽  
Tumor Site ◽  
Conventional Chemotherapy ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Ferromagnetic Particles

The activation of magnetic nanoparticles (mNPs) by an alternating magnetic field (AMF) is currently being explored as technique for targeted therapeutic heating of tumors. Various types of superparamagnetic and ferromagnetic particles, with different coatings and targeting agents, allow for tumor site and type specificity. Magnetic nanoparticle hyperthermia is also being studied as an adjuvant to conventional chemotherapy and radiation therapy. This review provides an introduction to some of the relevant biology and materials science involved in the technical development and current and future use of mNP hyperthermia as clinical cancer therapy.

Magnetic Nanoparticle Hyperthermia Cancer Therapy Temperature Distribution Modeling and Validation

2013 ◽  
Author(s):  
Robert V. Stigliano ◽  
Fridon Shubitidze ◽  
P. Jack Hoopes
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Strong Influence ◽  
Magnetic Interaction ◽  
Tumor Site ◽  
The Past ◽  
Distribution Modeling ◽  
Hyperthermia Therapy ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Tumor Types

The use of magnetic nanoparticles (mNP’s) in hyperthermia therapy for the treatment of cancer has been receiving increasing interest in the past few decades. It is known that heating cancerous tissues to temperatures above physiologically normal levels will cause cytotoxicity. In mNP hyperthermia, mNP’s are either injected intravenously or directly into the tumor site. In many tumor types the nanoparticles are invaginated into the cancer cells and aggregated into endosomes. Local temperature increases are achievable by exposing tumors containing mNP’s to an alternating magnetic field (AMF). The proximity of the mNP’s has a strong influence on their ability to generate heat due to inter-particle magnetic interaction effects [1, 2]. Taking this effect into account is important when modeling the heating characteristics of mNP’s.

scholarly journals Inductive Magnetic Nanoparticle Sensor Based on Microfluidic Chip Oil Detection Technology

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 183 ◽  
Author(s):  
Chenzhao Bai ◽  
Hongpeng Zhang ◽  
Lin Zeng ◽  
Xupeng Zhao ◽  
Laihao Ma
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Fault Diagnosis ◽  
Wear Debris ◽  
Magnetic Nanoparticle ◽  
Signal To Noise Ratio ◽  
Solenoid Coil ◽  
Signal To Noise ◽  
Detection Technology ◽  
Ferromagnetic Particles

The wear debris in hydraulic oil or lubricating oil has a wealth of equipment operating information, which is an important basis for large mechanical equipment detection and fault diagnosis. Based on traditional inductive oil detection technology, magnetic nanoparticles are exploited in this paper. A new inductive oil detection sensor is designed based on the characteristics of magnetic nanoparticles. The sensor improves detection sensitivity based on distinguishing between ferromagnetic and non-ferromagnetic wear debris. Magnetic nanoparticles increase the internal magnetic field strength of the solenoid coil and the stability of the internal magnetic field of the solenoid coil. During the experiment, the optimal position of the sensor microchannel was first determined, then the effect of the magnetic nanoparticles on the sensor’s detection was confirmed, and finally the concentration ratio of the mixture was determined. The experimental results show that the inductive oil detection sensor made of magnetic nanoparticle material had a higher detection effect, and the signal-to-noise ratio (SNR) of 20–70 μm ferromagnetic particles was increased by 20%–25%. The detection signal-to-noise ratio (SNR) of 80–130 μm non-ferromagnetic particles was increased by 16%–20%. The application of magnetic nanoparticles is a new method in the field of oil detection, which is of great significance for fault diagnosis and the life prediction of hydraulic systems.

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 9004-9012 ◽  
Author(s):  
Jinghua Li ◽  
Yan Hu ◽  
Yanhua Hou ◽  
Xinkun Shen ◽  
Gaoqiang Xu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Phase Change ◽  
Phase Change Material ◽  
Alternating Magnetic Field ◽  
Change Material

An alternating magnetic field triggered nanocarrier for drug delivery is fabricated for dual modal imaging-guided thermo-chemo cancer therapy.

scholarly journals Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5545 ◽  
Author(s):  
Izaz Raouf ◽  
Piotr Gas ◽  
Heung Soo Kim
Keyword(s):  
Numerical Model ◽  
Cancer Therapy ◽  
Magnetic Nanoparticle ◽  
Research Work ◽  
Thermal Response ◽  
Linear Response Theory ◽  
Novel Approach ◽  
Magnetic Nanoparticle Hyperthermia

Recently, in-vitro studies of magnetic nanoparticle (MNP) hyperthermia have attracted significant attention because of the severity of this cancer therapy for in-vivo culture. Accurate temperature evaluation is one of the key challenges of MNP hyperthermia. Hence, numerical studies play a crucial role in evaluating the thermal behavior of ferrofluids. As a result, the optimum therapeutic conditions can be achieved. The presented research work aims to develop a comprehensive numerical model that directly correlates the MNP hyperthermia parameters to the thermal response of the in-vitro model using optimization through linear response theory (LRT). For that purpose, the ferrofluid solution is evaluated based on various parameters, and the temperature distribution of the system is estimated in space and time. Consequently, the optimum conditions for the ferrofluid preparation are estimated based on experimental and mathematical findings. The reliability of the presented model is evaluated via the correlation analysis between magnetic and calorimetric methods for the specific loss power (SLP) and intrinsic loss power (ILP) calculations. Besides, the presented numerical model is verified with our experimental setup. In summary, the proposed model offers a novel approach to investigate the thermal diffusion of a non-adiabatic ferrofluid sample intended for MNP hyperthermia in cancer treatment.

scholarly journals Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16470-16480 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Eunjoo Kim ◽  
Sang Won Jeong ◽  
Tae-Lin Ha ◽  
Sang-Im Park ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Nanoparticle ◽  
Polymeric Micelles ◽  
Alternating Magnetic Field ◽  
Rapid Release

The cytotoxicity of magnetic nanoparticles-conjugated polymeric micelles encapsulated with an anticancer drug on cancer cells was enhanced by the synergistic effect of heat and the rapid release of the drug under an alternating magnetic field.

BIREFRINGENCE AND MAGNETO-OPTICAL PROPERTIES IN OLEIC ACID COATED Fe3O4 NANOPARTICLES: APPLICATION FOR OPTICAL SWITCH

2011 ◽  
Vol 10 (03) ◽  
pp. 515-520 ◽  
Author(s):  
SI-HUA XIA ◽  
JUN WANG ◽  
ZHANG-XIAN LU ◽  
FEIYAN ZHANG
Keyword(s):  
Magnetic Field ◽  
Optical Properties ◽  
Oleic Acid ◽  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Optical Switch ◽  
Colloidal Suspension ◽  
Experimental Parameters ◽  
Nanoparticle Chains ◽  
The Magnetic Field

We report magneto-optical properties in a kerosene colloidal suspension of oleic acid coated Fe3O4 nanoparticles (~14 nm). The magnetic colloids (fluids) show birefringence under a magnetic field. Systematical studies of the on–off switch times upon application of the on–off magnetic field with varied experimental parameters indicate that the switch response time depends strongly on the strength of the magnetic field and the concentration of the magnetic nanoparticles in the fluid. The data can be explained in terms of the formation of magnetic nanoparticle chains under a magnetic field. The important magneto-optical properties of the magnetic fluids allow us to design a tunable optical switch.

Enhancement in Treatment Planning for Magnetic Nanoparticle Hyperthermia: Optimization of the Heat Absorption Pattern

2009 ◽  
Author(s):  
Maher Salloum ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Relaxation Mechanism ◽  
Field Frequency ◽  
Nanoparticle Distribution ◽  
Injection Parameters ◽  
Absorption Pattern ◽  
Magnetic Nanoparticle Hyperthermia ◽  
Heating Pattern ◽  
Low Magnetic Field

Magnetic nanoparticle hyperthermia has potential to achieve optimal therapeutic results due to its ability to deliver adequate heating power to irregular and/or deep-seated tumor at low magnetic field frequency and amplitude [1]. The heat generated by the particles under the application of an external alternating magnetic field is mainly due to the Néel relaxation mechanism and/or Brownian motion of the particles [2]. In clinical applications, it is very important to ensure a maximum damage to the tumor while protecting the normal tissue. The resulted heating pattern by the nanoparticle distribution in tumor is closely related to the injection parameters [3, 4].

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