Injection of a Novel Biomimetic Aggrecan for the Restoration of Intervertebral Disc Tissue Mechanics

2013 ◽  
Author(s):  
Katsiaryna Prudnikova ◽  
David Jamison ◽  
Michele Marcolongo
Keyword(s):  
Extracellular Matrix ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Lower Back Pain ◽  
Mechanical Stability ◽  
Early Stage ◽  
Tissue Mechanics ◽  
Lower Back ◽  
Bottle Brush

Intervertebral disc degeneration and associated lower back pain is one of the leading musculoskeletal disorders confronting our health system with 15%–20% of the population experiencing lower back pain annually [1–4]. It has been shown that early in disc degeneration, the extracellular matrix of the nucleus pulposus is depleted of the proteoglycan aggrecan, resulting in loss of disc hydration, osmotic pressure and mechanical stability which leads to lower back pain [2, 5]. Early-stage restoration of the proteoglycan content within normal levels with natural aggrecan may help to restore disc functionality but it is cost prohibitive. We propose a new strategy to restore the extracellular matrix of the degenerated disc and mitigate lower back pain by molecularly engineering the disc matrix with an injection of a biomimetic aggrecan (BA) novel class of molecules that mimics the 3D bottle brush structure and physical properties of natural aggrecan.

scholarly journals Evaluation of injectable nucleus augmentation materials for the treatment of intervertebral disc degeneration

2022 ◽  
Author(s):  
Matthew Philip Culbert ◽  
James P Warren ◽  
Andrew R Dixon ◽  
Hazel Louise Fermor ◽  
Paul A. Beales ◽  
...  
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Lower Back Pain ◽  
Intervertebral Disc Degeneration ◽  
Economic Cost ◽  
Lower Back

Lower back pain affects a person’s health and mobility as well as creating a large economic cost. This is often caused by degeneration of the intervertebral disc. Current operative and...

Anti-degenerative effect of melatonin on intervertebral disc: protective contribution against inflammation, oxidative stress, apoptosis, and autophagy

2022 ◽  
Vol 23 ◽  
Author(s):  
Karim Hemati ◽  
Mohammad Hossein Pourhanifeh ◽  
Iman Fatemi ◽  
Azam Hosseinzadeh ◽  
Saeed Mehrzadi
Keyword(s):  
Oxidative Stress ◽  
Extracellular Matrix ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Lower Back Pain ◽  
Cartilage Tissue ◽  
Protective Effects ◽  
Lower Back ◽  
Collagen Ii ◽  
Ivd Degeneration

Abstract: Intervertebral disc (IVD) degeneration is a leading cause of lower back pain. Although the etiology of IVD degeneration (IVDD) is unclear, excessive oxidative stress, inflammation and apoptosis and disruption of autophagy play important role in the pathogenesis of IVDD. Therefore, finding a solution to mitigate these processes could stop or reduce the development of IVDD. Melatonin, a powerful antioxidant, plays an important role in regulating cartilage tissue hemostasis. Melatonin inhibits destruction of extracellular matrix (ECM) of disc. Melatonin preserves ECM contents including sox-9, aggrecan, and collagen II through inhibiting matrix degeneration enzymes such as MMP-13. These protective effects may be mediated by the inhibition of oxidative stress, inflammation and apoptosis, and regulation of autophagy in IVD cells.

Nucleus Implant Parameters Significantly Change the Compressive Stiffness of the Human Lumbar Intervertebral Disc

2005 ◽  
Vol 127 (3) ◽  
pp. 536-540 ◽  
Author(s):  
Abhijeet Joshi ◽  
Samir Mehta ◽  
Edward Vresilovic ◽  
Andrew Karduna ◽  
Michele Marcolongo
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Lower Back Pain ◽  
Recent Trend ◽  
Intervertebral Discs ◽  
Geometric Parameters ◽  
Synthetic Material ◽  
Lumbar Intervertebral Disc ◽  
Compressive Stiffness ◽  
Lower Back

Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

scholarly journals Intervertebral Disc Degeneration and Low Back Pain: Molecular Mechanisms and Stem Cell Therapy

2018 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Anna Meiliana ◽  
Nurrani Mustika Dewi ◽  
Andi Wijaya
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Low Back

BACKGROUND: Low back pain (LBP) mostly caused by disc degeneration, reflects to a tremendous of health care system and economy. More knowledge about these underlying pathologies will improve the opportunities that may represent critical therapeutic targets.CONTENT: Basic research is advancing the understanding of the pathogenesis and management of LBP at the molecular and genetic levels. Cytokines such as matrix metalloproteinases, phospholipase A2, nitric oxide, and tumor necrosis factor-α are thought to contribute to the development of LBP. Mesenchymal stem cells (MSCs) transplant to cartilage-like cells and secrete extracellular matrix and encourage nucleus pulposus (NP) cell activity inhibiting NP cell apoptosis, together with some chemical mediators such as cytokines and growth factors become a safe and effective new strategy for intervertebral disc degeneration (IDD) treatment and regeneration.SUMMARY: IDD occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile. A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians to help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies.KEYWORDS: low back pain (LBP), intervertebral disc (IVD), degeneration, nucleus pulposus (NP), annulus fibrosus (AF), extracellular matrix (ECM), genetic, stem cells

scholarly journals Detecting Lower Back Pain Using Stacked Ensemble Approach

2020 ◽  
Author(s):  
Samir Bandyopadhyay ◽  
Shawni Dutta
Keyword(s):  
Back Pain ◽  
Lower Back Pain ◽  
Early Stage ◽  
Ensemble Classifier ◽  
Experimental Result ◽  
Counter Measures ◽  
Lower Back ◽  
Ensemble Machine Learning ◽  
Absence From Work ◽  
Previous Occupation

Lower Back Pain (LBP) is a disease that needs immediate attention. Person with back pain shall go immediately to doctor for treatment. Injury, excessive works and some medical conditions are result of back pain. Back pain is common to any age of human for different reasons. Due to factors such as previous occupation and degenerative disk disease the chance of developing lower back pain increases for older people. It hampers the working condition of people common reason for seeking medical treatment. The result is absence from work and is unable to normal due to pain. It creates uncomfortable and debilitating situations. Hence, detecting this disease at an early stage will assist the medical field experts to suggest counter measures to the patients. Detection of lower back pain is implemented in this paper by applying ensemble machine learning technique. This paper proposes Stacking ensemble classifier as an automated tool that will predict lower back pain tendency of a patient. Experimental result implies that the proposed method reaches an accuracy of 76.34%, f1-score of 0.76 and MSE of 0.34.

Pathological Effects of Cortisol on Intervertebral Disc Cells and Mesenchymal Stem Cells from Lower Back Pain Patients

2019 ◽  
Vol 207 (1) ◽  
pp. 34-45 ◽  
Author(s):  
Daphne Hingert ◽  
Johanna Nilsson ◽  
Helena Barreto Henriksson ◽  
Adad Baranto ◽  
Helena Brisby
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Back Pain ◽  
Disc Degeneration ◽  
Lower Back Pain ◽  
Cell Types ◽  
The Body ◽  
Lower Back ◽  
Induced Stress ◽  
Disc Cells

In western countries, lower back pain (LBP) is one of the most common disorders, experienced by more than 80% of the population. Chronic LBP due to disc degeneration has been linked to ongoing inflammatory processes in the disc and endplates. Pain effects the body in different ways, inducing a general stress response in which the body responds by releasing the stress hormone cortisol. Little is known about the impact of pain-induced stress on the progression of disc degeneration. Thus, the effects of cortisol on disc cells (DCs) and human mesenchymal stem cells (hMSCs) were explored in vitro with the objective of investigating the repercussions of cortisol on these cell types involved in de- and regenerative mechanisms of the disc. DC and hMSC pellet cultures were exposed to cortisol at two concentrations (150 and 300 ng/mL) for 28 days to simulate pain-induced stress. Cell viability, histological staining, and GAG DNA, along with apo­ptotic assays were conducted. Detection of OCT4, SOX9, IL-1R, and CXCR2 expressions was performed by immunohistochemistry. With cortisol treatment, restricted cell proliferation and less GAG production in both DCs and hMSCs were observed. Suppression of the differentiation and immunomodulatory efficacy of hMSCs was also detected. Moreover, elevated expressions of IL-1R and CXCR2 were detected in both cell types. To conclude, constant exposure to cortisol even at a physiological level enhanced pathological cellular processes in both DCs and hMSCs, which further jeopardized chondrogenesis. This suggests that cortisol resulting from pain-induced stress is a contributing component of intervertebral disc degeneration and may negatively affect regenerative attempts of the disc.

scholarly journals Osteoporotic vertebral fracture misdiagnosed as “normal postoperative phenomenon” in post decompression surgery: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Li-sheng Hou ◽  
Dong Zhang ◽  
Feng Ge ◽  
Hai-feng Li ◽  
Tian-jun Gao
Keyword(s):  
Back Pain ◽  
Vertebral Fracture ◽  
Lower Back Pain ◽  
Early Stage ◽  
Decompression Surgery ◽  
Spinal Diseases ◽  
Osteoporotic Vertebral Fracture ◽  
Early Recovery ◽  
Lower Back ◽  
First Case

Abstract Background Previous research and published literature indicate that some patients with spinal diseases who underwent percutaneous transforaminal endoscopic decompression (PTED) still suffer some discomfort in the early recovery stage in the form of pain, stiffness, and swelling. These are usually considered minor residual symptoms or normal postoperative phenomenon (NPF) in the clinic, occur frequently, and are acknowledged by surgeons worldwide. To the best of our knowledge, we report the first case of a patient who had an osteoporotic vertebral fracture (OVF) misdiagnosed as NPF after she underwent PTED as a result of lumbar disc herniation (LDH). Case presentation A 71-year-old female with Parkinson’s disease who presented with lower back pain radiating to the legs was diagnosed as LDH in L4–5, after which a PTED of L4–5 was performed, with temporary alleviation of symptoms. However, severe lower back pain recurred. Unfortunately, the recurred pain initially misdiagnosed as NPF, in fact, was finally confirmed to be OVF by CT-scan. OVF in the early stage of post-PTED seldom occurs and is rarely reported in the literature. With a percutaneous vertebroplasty, the pain was significantly relieved, and she resumed walking. After 36-weeks of follow-up, the pain improved satisfactorily. Conclusion Doctors should not immediately diagnose a relapse of back pain following PTED as NPF, and hands-on careful physical and imaging examinations are necessary to manage recurring pain rightly and timely.

A novel radiofrequency thermocoagulation method for treatment of lower back pain: thermal conduction after instillation of saline solution into the nucleus pulposus—preliminary results

2008 ◽  
Vol 49 (8) ◽  
pp. 934-939
Author(s):  
N. Azulay ◽  
M. Forgerit ◽  
E. G. Alava ◽  
A. Deplas ◽  
R. Vialle ◽  
...  
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Lower Back Pain ◽  
Clinical Benefit ◽  
New Method ◽  
Disability Score ◽  
Lumbar Intervertebral Disc ◽  
Lower Back ◽  
Radiofrequency Heating

Background: Radiofrequency heating of the intervertebral disc has been proposed for the treatment of chronic low back pain using two methods: a flexible needle inserted into the annulus fibrosus achieving a full 360° penetration, or a rigid needle inserted into the nucleus pulposus. The first technique is effective on pain, but the clinical benefit of the second is uncertain. Purpose: To evaluate a technique for radiofrequency heating of the lumbar intervertebral disc by a needle placed into the nucleus pulposus. Material and Methods: The method was tested in 17 patients according to the criteria used in previous intradiscal radiofrequency studies. Before and after treatment, disability was assessed by the Oswestry disability score. A pain reduction of at least 50% was considered a success. Results: Fifteen patients were responders at 1 month (88%), nine at 3 months (53%), and 12 at 6 months (70.6%). No complications were observed. Conclusion: A new method of providing discal radiofrequency treatment for lower back pain had a substantial clinical benefit in 71% of the observed patients. A prospective study comparing this new method with placebo should be conducted to confirm these initial results.

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