Real-time,in vivomeasurement of tissular pO2 through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

2012 ◽  
Vol 17 (11) ◽  
pp. 115007 ◽  
Author(s):  
Filippo Piffaretti ◽  
Anna Maria Novello ◽  
Rajendran Senthil Kumar ◽  
Eddy Forte ◽  
Cédric Paulou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Protoporphyrin Ix ◽  
Delayed Fluorescence

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix

scholarly journals Understanding delayed fluorescence and triplet decays of Protoporphyrin IX under hypoxic conditions

2021 ◽  
Author(s):  
Marek Scholz ◽  
Gauthier Croizat ◽  
Jakub Pšenčík ◽  
Roman Dědic ◽  
Santi Nonell ◽  
...  
Keyword(s):  
Protoporphyrin Ix ◽  
Delayed Fluorescence ◽  
Hypoxic Conditions

scholarly journals Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy

2021 ◽  
Vol 14 (3) ◽  
pp. 229
Author(s):  
Yo Shinoda ◽  
Daitetsu Kato ◽  
Ryosuke Ando ◽  
Hikaru Endo ◽  
Tsutomu Takahashi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Human Cancer ◽  
Meta Analysis ◽  
Protoporphyrin Ix ◽  
Cell Types ◽  
Amino Acid Derivative ◽  
Photodynamic Diagnosis

5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These clinical applications are potentially based on in vitro cell culture experiments. Thus, conducting a systematic review and meta-analysis of in vitro 5-ALA PDT experiments is meaningful and may provide opportunities to consider future perspectives in this field. We conducted a systematic literature search in PubMed to summarize the in vitro 5-ALA PDT experiments and calculated the effectiveness of 5-ALA PDT for several cancer cell types. In total, 412 articles were identified, and 77 were extracted based on our inclusion criteria. The calculated effectiveness of 5-ALA PDT was statistically analyzed, which revealed a tendency of cancer-classification-dependent sensitivity to 5-ALA PDT, and stomach cancer was significantly more sensitive to 5-ALA PDT compared with cancers of different origins. Based on our analysis, we suggest a standardized in vitro experimental protocol for 5-ALA PDT.

Singlet oxygen feedback delayed fluorescence of protoporphyrin IX in organic solutions

2017 ◽  
Vol 16 (4) ◽  
pp. 507-518 ◽  
Author(s):  
Ivo S. Vinklárek ◽  
Marek Scholz ◽  
Roman Dědic ◽  
Jan Hála
Keyword(s):  
Partial Pressure ◽  
Singlet Oxygen ◽  
Protoporphyrin Ix ◽  
Clinical Applications ◽  
Delayed Fluorescence ◽  
Diagnostic Tools ◽  
Partial Pressure Of Oxygen ◽  
High Concentrations ◽  
Organic Solutions

The PpIX DF show the significant role of SOFDF mechanism at high concentrations and at atmospheric partial pressure of oxygen and should be considered when developing diagnostic tools for clinical applications.

scholarly journals Real-Time Monitoring of Photocytotoxicity in Nanoparticles-Based Photodynamic Therapy: A Model-Based Approach

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48617 ◽  
Author(s):  
Hamanou Benachour ◽  
Thierry Bastogne ◽  
Magali Toussaint ◽  
Yosra Chemli ◽  
Aymeric Sève ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Real Time Monitoring ◽  
Model Based
Sign in / Sign up

Export Citation Format

Share Document