Generative synthetic adversarial network for internal bias correction and handling class imbalance problem in medical image diagnosis

Author(s):  
Mina Rezaei ◽  
Tomoki Uemura ◽  
Janne Nappi ◽  
Hiroyuki Yoshida ◽  
Christoph Lippert ◽  
...  
2019 ◽  
Vol 490 (4) ◽  
pp. 5424-5439 ◽  
Author(s):  
Ping Guo ◽  
Fuqing Duan ◽  
Pei Wang ◽  
Yao Yao ◽  
Qian Yin ◽  
...  

ABSTRACT Discovering pulsars is a significant and meaningful research topic in the field of radio astronomy. With the advent of astronomical instruments, the volume and rate of data acquisition have grown exponentially. This development necessitates a focus on artificial intelligence (AI) technologies that can mine large astronomical data sets. Automatic pulsar candidate identification (APCI) can be considered as a task determining potential candidates for further investigation and eliminating the noise of radio-frequency interference and other non-pulsar signals. As reported in the existing literature, AI techniques, especially convolutional neural network (CNN)-based techniques, have been adopted for APCI. However, it is challenging to enhance the performance of CNN-based pulsar identification because only an extremely limited number of real pulsar samples exist, which results in a crucial class imbalance problem. To address these problems, we propose a framework that combines a deep convolution generative adversarial network (DCGAN) with a support vector machine (SVM). The DCGAN is used as a sample generation and feature learning model, and the SVM is adopted as the classifier for predicting the label of a candidate at the inference stage. The proposed framework is a novel technique, which not only can solve the class imbalance problem but also can learn the discriminative feature representations of pulsar candidates instead of computing hand-crafted features in the pre-processing steps. The proposed method can enhance the accuracy of the APCI, and the computer experiments performed on two pulsar data sets verified the effectiveness and efficiency of the proposed method.


2020 ◽  
Vol 15 (11) ◽  
pp. 1847-1858
Author(s):  
Mina Rezaei ◽  
Janne J. Näppi ◽  
Christoph Lippert ◽  
Christoph Meinel ◽  
Hiroyuki Yoshida

Abstract Purpose The identification of abnormalities that are relatively rare within otherwise normal anatomy is a major challenge for deep learning in the semantic segmentation of medical images. The small number of samples of the minority classes in the training data makes the learning of optimal classification challenging, while the more frequently occurring samples of the majority class hamper the generalization of the classification boundary between infrequently occurring target objects and classes. In this paper, we developed a novel generative multi-adversarial network, called Ensemble-GAN, for mitigating this class imbalance problem in the semantic segmentation of abdominal images. Method The Ensemble-GAN framework is composed of a single-generator and a multi-discriminator variant for handling the class imbalance problem to provide a better generalization than existing approaches. The ensemble model aggregates the estimates of multiple models by training from different initializations and losses from various subsets of the training data. The single generator network analyzes the input image as a condition to predict a corresponding semantic segmentation image by use of feedback from the ensemble of discriminator networks. To evaluate the framework, we trained our framework on two public datasets, with different imbalance ratios and imaging modalities: the Chaos 2019 and the LiTS 2017. Result In terms of the F1 score, the accuracies of the semantic segmentation of healthy spleen, liver, and left and right kidneys were 0.93, 0.96, 0.90 and 0.94, respectively. The overall F1 scores for simultaneous segmentation of the lesions and liver were 0.83 and 0.94, respectively. Conclusion The proposed Ensemble-GAN framework demonstrated outstanding performance in the semantic segmentation of medical images in comparison with other approaches on popular abdominal imaging benchmarks. The Ensemble-GAN has the potential to segment abdominal images more accurately than human experts.


Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1906
Author(s):  
Jia-Zheng Jian ◽  
Tzong-Rong Ger ◽  
Han-Hua Lai ◽  
Chi-Ming Ku ◽  
Chiung-An Chen ◽  
...  

Diverse computer-aided diagnosis systems based on convolutional neural networks were applied to automate the detection of myocardial infarction (MI) found in electrocardiogram (ECG) for early diagnosis and prevention. However, issues, particularly overfitting and underfitting, were not being taken into account. In other words, it is unclear whether the network structure is too simple or complex. Toward this end, the proposed models were developed by starting with the simplest structure: a multi-lead features-concatenate narrow network (N-Net) in which only two convolutional layers were included in each lead branch. Additionally, multi-scale features-concatenate networks (MSN-Net) were also implemented where larger features were being extracted through pooling the signals. The best structure was obtained via tuning both the number of filters in the convolutional layers and the number of inputting signal scales. As a result, the N-Net reached a 95.76% accuracy in the MI detection task, whereas the MSN-Net reached an accuracy of 61.82% in the MI locating task. Both networks give a higher average accuracy and a significant difference of p < 0.001 evaluated by the U test compared with the state-of-the-art. The models are also smaller in size thus are suitable to fit in wearable devices for offline monitoring. In conclusion, testing throughout the simple and complex network structure is indispensable. However, the way of dealing with the class imbalance problem and the quality of the extracted features are yet to be discussed.


Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2803
Author(s):  
Rabeea Jaffari ◽  
Manzoor Ahmed Hashmani ◽  
Constantino Carlos Reyes-Aldasoro

The segmentation of power lines (PLs) from aerial images is a crucial task for the safe navigation of unmanned aerial vehicles (UAVs) operating at low altitudes. Despite the advances in deep learning-based approaches for PL segmentation, these models are still vulnerable to the class imbalance present in the data. The PLs occupy only a minimal portion (1–5%) of the aerial images as compared to the background region (95–99%). Generally, this class imbalance problem is addressed via the use of PL-specific detectors in conjunction with the popular class balanced cross entropy (BBCE) loss function. However, these PL-specific detectors do not work outside their application areas and a BBCE loss requires hyperparameter tuning for class-wise weights, which is not trivial. Moreover, the BBCE loss results in low dice scores and precision values and thus, fails to achieve an optimal trade-off between dice scores, model accuracy, and precision–recall values. In this work, we propose a generalized focal loss function based on the Matthews correlation coefficient (MCC) or the Phi coefficient to address the class imbalance problem in PL segmentation while utilizing a generic deep segmentation architecture. We evaluate our loss function by improving the vanilla U-Net model with an additional convolutional auxiliary classifier head (ACU-Net) for better learning and faster model convergence. The evaluation of two PL datasets, namely the Mendeley Power Line Dataset and the Power Line Dataset of Urban Scenes (PLDU), where PLs occupy around 1% and 2% of the aerial images area, respectively, reveal that our proposed loss function outperforms the popular BBCE loss by 16% in PL dice scores on both the datasets, 19% in precision and false detection rate (FDR) values for the Mendeley PL dataset and 15% in precision and FDR values for the PLDU with a minor degradation in the accuracy and recall values. Moreover, our proposed ACU-Net outperforms the baseline vanilla U-Net for the characteristic evaluation parameters in the range of 1–10% for both the PL datasets. Thus, our proposed loss function with ACU-Net achieves an optimal trade-off for the characteristic evaluation parameters without any bells and whistles. Our code is available at Github.


Author(s):  
Sayan Surya Shaw ◽  
Shameem Ahmed ◽  
Samir Malakar ◽  
Laura Garcia-Hernandez ◽  
Ajith Abraham ◽  
...  

AbstractMany real-life datasets are imbalanced in nature, which implies that the number of samples present in one class (minority class) is exceptionally less compared to the number of samples found in the other class (majority class). Hence, if we directly fit these datasets to a standard classifier for training, then it often overlooks the minority class samples while estimating class separating hyperplane(s) and as a result of that it missclassifies the minority class samples. To solve this problem, over the years, many researchers have followed different approaches. However the selection of the true representative samples from the majority class is still considered as an open research problem. A better solution for this problem would be helpful in many applications like fraud detection, disease prediction and text classification. Also, the recent studies show that it needs not only analyzing disproportion between classes, but also other difficulties rooted in the nature of different data and thereby it needs more flexible, self-adaptable, computationally efficient and real-time method for selection of majority class samples without loosing much of important data from it. Keeping this fact in mind, we have proposed a hybrid model constituting Particle Swarm Optimization (PSO), a popular swarm intelligence-based meta-heuristic algorithm, and Ring Theory (RT)-based Evolutionary Algorithm (RTEA), a recently proposed physics-based meta-heuristic algorithm. We have named the algorithm as RT-based PSO or in short RTPSO. RTPSO can select the most representative samples from the majority class as it takes advantage of the efficient exploration and the exploitation phases of its parent algorithms for strengthening the search process. We have used AdaBoost classifier to observe the final classification results of our model. The effectiveness of our proposed method has been evaluated on 15 standard real-life datasets having low to extreme imbalance ratio. The performance of the RTPSO has been compared with PSO, RTEA and other standard undersampling methods. The obtained results demonstrate the superiority of RTPSO over state-of-the-art class imbalance problem-solvers considered here for comparison. The source code of this work is available in https://github.com/Sayansurya/RTPSO_Class_imbalance.


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