Control of protein absorption for MEMs and microfluidic applications on silicon surfaces using silane-based self-assembled monolayers of an oligo(ethylene oxide) derivative

Author(s):  
Thomas W. Schneider ◽  
Laura E. Aloi ◽  
Robert C. White
Langmuir ◽  
2012 ◽  
Vol 28 (7) ◽  
pp. 3403-3411 ◽  
Author(s):  
Koen van der Maaden ◽  
Karen Sliedregt ◽  
Alexander Kros ◽  
Wim Jiskoot ◽  
Joke Bouwstra

2014 ◽  
Vol 5 (1) ◽  
pp. 149 ◽  
Author(s):  
Hadas Alon ◽  
Idan Bakish ◽  
Josh Nehrer ◽  
Assaf Y. Anderson ◽  
Chaim N. Sukenik ◽  
...  

Langmuir ◽  
1998 ◽  
Vol 14 (24) ◽  
pp. 6916-6923 ◽  
Author(s):  
David J. Vanderah ◽  
Curtis W. Meuse ◽  
Vitalii Silin ◽  
Anne L. Plant

2010 ◽  
Vol 604 (17-18) ◽  
pp. 1388-1394 ◽  
Author(s):  
Cheuk Chi Albert Ng ◽  
Simone Ciampi ◽  
Jason B. Harper ◽  
J. Justin Gooding

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.


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