Physical Chemistry of Nonfouling Oligo (Ethylene Oxide)-Terminated Self-Assembled Monolayers

2013 ◽  
pp. 59-98
Author(s):  
Michael Grunze
Keyword(s):  
Physical Chemistry ◽  
Ethylene Oxide ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Self Assembled

Synthesis and Characterization of Self-Assembled Monolayers of Alkylated 1-Thiahexa(ethylene oxide) Compounds on Gold

Langmuir ◽  
1998 ◽  
Vol 14 (24) ◽  
pp. 6916-6923 ◽  
Author(s):  
David J. Vanderah ◽  
Curtis W. Meuse ◽  
Vitalii Silin ◽  
Anne L. Plant
Keyword(s):  
Ethylene Oxide ◽  
Self Assembled Monolayers ◽  
Synthesis And Characterization ◽  
Assembled Monolayers ◽  
Self Assembled

Self-Assembled Monolayers as Models for Studying Protein Adsorption to Polymer Surfaces

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Organic Materials ◽  
Polymer Surfaces ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Protein Resistant ◽  
Poly Ethylene

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.

Membrane protein resistance of oligo(ethylene oxide) self-assembled monolayers

2014 ◽  
Vol 122 ◽  
pp. 552-558 ◽  
Author(s):  
Amit Vaish ◽  
David J. Vanderah ◽  
Ryan Vierling ◽  
Fay Crawshaw ◽  
D. Travis Gallagher ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Ethylene Oxide ◽  
Self Assembled Monolayers ◽  
Protein Resistance ◽  
Assembled Monolayers ◽  
Self Assembled

Helical, Disordered, and What that Means: Structural Characterization of a New Series of Methyl 1-Thiaoligo(ethylene Oxide) Self-Assembled Monolayers

2002 ◽  
Vol 724 ◽  
Author(s):  
David J. Vanderah ◽  
Jennifer Arsenault ◽  
Hongly La ◽  
Vitalii Silin ◽  
Curtis W. Meuse ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Helical Structure ◽  
Helical Conformation ◽  
Self Assembled Monolayers ◽  
Reflection Absorption Infrared Spectroscopy ◽  
Assembled Monolayers ◽  
Polycrystalline Gold ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Poly Ethylene

AbstractSelf-assembled monolayers (SAMs) of a series of linear thiols containing a 1-thiaoligo(ethylene oxide) [TOEO] moiety, i.e., HS(CH2CH2O)xCH3, where x = 3 - 6, were prepared on polycrystalline gold (Au) and characterized by reflection absorption infrared spectroscopy (RAIRS) and spectroscopic ellipsometry (SE). For x = 5 and 6, the RAIRS data show that the TOEO segment, oriented normal to the substrate, adopts the highly ordered 7/2 helical structure of the folded-chain crystal polymorph of poly(ethylene oxide). For x = 3 and 4, the RAIRS and SE data indicate disordered, “amorphous” SAMs with essentially no evidence of the helical conformation in the TOEO segment. These data suggest that, for SAMs with TOEO segments, a minimum of five ethylene oxide units is required to adopt a helical conformation.

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