scholarly journals A semi-empirical model for the therapeutic range shift estimation caused by inhomogeneities in proton beam therapy

2012 ◽  
Vol 13 (2) ◽  
pp. 3-12 ◽  
Author(s):  
Vadim Moskvin ◽  
Chee-Wai Cheng ◽  
Leia Fanelli ◽  
Li Zhao ◽  
Indra J. Das
2019 ◽  
Author(s):  
Gustavo Rangel ◽  
Mostafa Shahein ◽  
Thiago Felicio ◽  
Guilhermo Malave ◽  
Nyall London ◽  
...  

Skull Base ◽  
2008 ◽  
Vol 18 (S 01) ◽  
Author(s):  
Annie Chan ◽  
Paul Busse ◽  
Urmila Kamat ◽  
Derrick Lin ◽  
Norbert Liebsch

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 412
Author(s):  
Shao-Ming Li ◽  
Kai-Shing Yang ◽  
Chi-Chuan Wang

In this study, a quantitative method for classifying the frost geometry is first proposed to substantiate a numerical model in predicting frost properties like density, thickness, and thermal conductivity. This method can recognize the crystal shape via linear programming of the existing map for frost morphology. By using this method, the frost conditions can be taken into account in a model to obtain the corresponding frost properties like thermal conductivity, frost thickness, and density for specific frost crystal. It is found that the developed model can predict the frost properties more accurately than the existing correlations. Specifically, the proposed model can identify the corresponding frost shape by a dimensionless temperature and the surface temperature. Moreover, by adopting the frost identification into the numerical model, the frost thickness can also be predicted satisfactorily. The proposed calculation method not only shows better predictive ability with thermal conductivities, but also gives good predictions for density and is especially accurate when the frost density is lower than 125 kg/m3. Yet, the predictive ability for frost density is improved by 24% when compared to the most accurate correlation available.


Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1862
Author(s):  
Eva Biewald ◽  
Tobias Kiefer ◽  
Dirk Geismar ◽  
Sabrina Schlüter ◽  
Anke Manthey ◽  
...  

Despite the increased risk of subsequent primary tumors (SPTs) external beam radiation (EBRT) may be the only therapeutic option to preserve a retinoblastoma eye. Due to their physical properties, proton beam therapy (PBT) offers the possibility to use the effectiveness of EBRT in tumor treatment and to decisively reduce the treatment-related morbidity. We report our experiences of PBT as rescue therapy in a retrospectively studied cohort of 15 advanced retinoblastoma eyes as final option for eye-preserving therapy. The average age at the initiation of PBT was 35 (14–97) months, mean follow-up was 22 (2–46) months. Prior to PBT, all eyes were treated with systemic chemotherapy and a mean number of 7.1 additional treatments. Indication for PBT was non-feasibility of intra-arterial chemotherapy (IAC) in 10 eyes, tumor recurrence after IAC in another 3 eyes and diffuse infiltrating retinoblastoma in 2 eyes. Six eyes (40%) were enucleated after a mean time interval of 4.8 (1–8) months. Cataract formation was the most common complication affecting 44.4% of the preserved eyes, yet 77.8% achieved a visual acuity of >20/200. Two of the 15 children treated developed metastatic disease during follow-up, resulting in a 13.3% metastasis rate. PBT is a useful treatment modality as a rescue therapy in retinoblastoma eyes with an eye-preserving rate of 60%. As patients are at lifetime risk of SPTs consistent monitoring is mandatory.


2021 ◽  
Vol 212 ◽  
pp. 104606
Author(s):  
Firouzeh Souri ◽  
Hua Ge ◽  
Ted Stathopoulos

Author(s):  
A.L. Polishchuk ◽  
D.H. Char ◽  
V. Weinberg ◽  
I.K. Daftari ◽  
T.B. Cole ◽  
...  

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