Fat-Free Mass Changes During Ketogenic Diets and the Potential Role of Resistance Training

2016 ◽  
Vol 26 (1) ◽  
pp. 78-92 ◽  
Author(s):  
Grant M. Tinsley ◽  
Darryn S. Willoughby
Keyword(s):  
Weight Loss ◽  
Resistance Training ◽  
Ketogenic Diet ◽  
Potential Role ◽  
Mass Measurement ◽  
Fat Free Mass ◽  
Exercise Interventions ◽  
Ketogenic Diets ◽  
Low Carbohydrate

Low-carbohydrate and very-low-carbohydrate diets are often used as weight-loss strategies by exercising individuals and athletes. Very-low-carbohydrate diets can lead to a state of ketosis, in which the concentration of blood ketones (acetoacetate, 3-β-hydroxybutyrate, and acetone) increases as a result of increased fatty acid breakdown and activity of ketogenic enzymes. A potential concern of these ketogenic diets, as with other weight-loss diets, is the potential loss of fat-free mass (e.g., skeletal muscle). On examination of the literature, the majority of studies report decreases in fat-free mass in individuals following a ketogenic diet. However, some confounding factors exist, such as the use of aggressive weight-loss diets and potential concerns with fat-free mass measurement. A limited number of studies have examined combining resistance training with ketogenic diets, and further research is needed to determine whether resistance training can effectively slow or stop the loss of fat-free mass typically seen in individuals following a ketogenic diet. Mechanisms underlying the effects of a ketogenic diet on fat-free mass and the results of implementing exercise interventions in combination with this diet should also be examined.

Successful Weight Loss with Low Carbohydrate Ketogenic Diet (LCKD) Significantly Reduced Visceral Fat and Increased Fat Free Mass in Obese

2017 ◽  
Vol 152 (5) ◽  
pp. S831
Author(s):  
Susan Wolver ◽  
Venkata Rajesh Konjeti ◽  
Salvatore Carbone ◽  
Antonio Abbate ◽  
Puneet Puri
Keyword(s):  
Weight Loss ◽  
Ketogenic Diet ◽  
Visceral Fat ◽  
Fat Free Mass ◽  
Low Carbohydrate ◽  
Successful Weight Loss

A high-fat, ketogenic diet induces a unique metabolic state in mice

2007 ◽  
Vol 292 (6) ◽  
pp. E1724-E1739 ◽  
Author(s):  
Adam R. Kennedy ◽  
Pavlos Pissios ◽  
Hasan Otu ◽  
Bingzhong Xue ◽  
Kenji Asakura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Energy Expenditure ◽  
Ketogenic Diet ◽  
Metabolic Effects ◽  
Acid Oxidation ◽  
High Fat ◽  
Metabolic State ◽  
Ketogenic Diets ◽  
Low Carbohydrate

Ketogenic diets have been used as an approach to weight loss on the basis of the theoretical advantage of a low-carbohydrate, high-fat diet. To evaluate the physiological and metabolic effects of such diets on weight we studied mice consuming a very-low-carbohydrate, ketogenic diet (KD). This diet had profound effects on energy balance and gene expression. C57BL/6 mice animals were fed one of four diets: KD; a commonly used obesogenic high-fat, high-sucrose diet (HF); 66% caloric restriction (CR); and control chow (C). Mice on KD ate the same calories as mice on C and HF, but weight dropped and stabilized at 85% initial weight, similar to CR. This was consistent with increased energy expenditure seen in animals fed KD vs. those on C and CR. Microarray analysis of liver showed a unique pattern of gene expression in KD, with increased expression of genes in fatty acid oxidation pathways and reduction in lipid synthesis pathways. Animals made obese on HF and transitioned to KD lost all excess body weight, improved glucose tolerance, and increased energy expenditure. Analysis of key genes showed similar changes as those seen in lean animals placed directly on KD. Additionally, AMP kinase activity was increased, with a corresponding decrease in ACC activity. These data indicate that KD induces a unique metabolic state congruous with weight loss.

Are We Exploring the Potential Role of Specialized Techniques in Muscle Hypertrophy?

2021 ◽  
Author(s):  
Witalo Kassiano ◽  
Bruna Daniella de Vasconcelos Costa ◽  
João Pedro Nunes ◽  
Andreo Fernando Aguiar ◽  
Belmiro F. de Salles ◽  
...  
Keyword(s):  
Resistance Training ◽  
Muscle Hypertrophy ◽  
Potential Role ◽  
Ecological Validity ◽  
Trained Subjects ◽  
Training Techniques ◽  
Methodological Rigor ◽  
Traditional Resistance Training ◽  
Intervening Variables

AbstractSpecialized resistance training techniques (e.g., drop-set, rest-pause) are commonly used by well-trained subjects for maximizing muscle hypertrophy. Most of these techniques were designed to allow a greater training volume (i.e., total repetitions×load), due to the supposition that it elicits greater muscle mass gains. However, many studies that compared the traditional resistance training configuration with specialized techniques seek to equalize the volume between groups, making it difficult to determine the inherent hypertrophic potential of these advanced strategies, as well as, this equalization restricts part of the practical extrapolation on these findings. In this scenario, the objectives of this manuscript were 1) to present the nuance of the evidence that deals with the effectiveness of these specialized resistance training techniques and — primarily — to 2) propose possible ways to explore the hypertrophic potential of such strategies with greater ecological validity without losing the methodological rigor of controlling possible intervening variables; and thus, contributing to increasing the applicability of the findings and improving the effectiveness of hypertrophy-oriented resistance training programs.

scholarly journals Erratum: Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

2014 ◽  
Vol 68 (5) ◽  
pp. 641-641
Author(s):  
A Paoli ◽  
A Rubini ◽  
J S Volek ◽  
K A Grimaldi
Keyword(s):  
Weight Loss ◽  
Ketogenic Diets ◽  
Therapeutic Uses ◽  
Low Carbohydrate

VERY LOW-CARBOHYDRATE KETOGENIC DIET FOR THE TREATMENT OF SEVERE OBESITY AND ASSOCIATED NON-ALCOHOLIC FATTY LIVER DISEASE: THE ROLE OF SEX DIFFERENCES

Nutrition ◽  
2021 ◽  
Vol 87-88 ◽  
pp. 111327
Author(s):  
M. D'Abbondanza ◽  
S. Ministrini ◽  
G. Pucci ◽  
E. Nulli Migliola ◽  
E.E. Martorelli ◽  
...  
Keyword(s):  
Sex Differences ◽  
Liver Disease ◽  
Fatty Liver ◽  
Ketogenic Diet ◽  
Fatty Liver Disease ◽  
Severe Obesity ◽  
Alcoholic Fatty Liver ◽  
Low Carbohydrate ◽  
Alcoholic Fatty Liver Disease

scholarly journals Comparing the Keyto App and Device with Weight Watchers’ WW App for Weight Loss: Protocol for a Randomized Trial

10.2196/19053 ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. e19053
Author(s):  
Sean R Locke ◽  
Kaja Falkenhain ◽  
Dylan A Lowe ◽  
Terry Lee ◽  
Joel Singer ◽  
...  
Keyword(s):  
Weight Loss ◽  
Cardiovascular Risk ◽  
Randomized Trial ◽  
Ketogenic Diet ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Ketogenic Diets ◽  
Phone Calls ◽  
Weight Watchers ◽  
The Impact

Background Obesity and being overweight are major contributing factors for many diseases. Calorie restricted diets often fail to result in sustained long-term weight loss. Very low–carbohydrate, high-fat ketogenic diets have been suggested to have superior metabolic and weight loss effects. Keyto is a low-cost, highly scalable mobile health (mHealth) app paired with a noninvasive biofeedback tool aimed at facilitating weight loss through a personalized healthy and predominantly plant- and fish-based ketogenic diet. Objective This protocol describes a randomized trial comparing the efficacy of the Keyto mHealth app and device intervention to that of Weight Watchers’ WW app in individuals who are overweight or obese. The primary outcome is weight loss after 12 weeks. Secondary and exploratory outcomes, including metabolic and cardiovascular risk factors, will be assessed at 12, 24, and 48 weeks. Methods A total of 144 participants will be recruited and randomized to either the Keyto program or Weight Watchers program. Study participants will be guided through the study via video conference or phone calls and will undergo a fasting blood analysis performed by a third-party diagnostic lab at weeks 0 and 12 to assess metabolic and cardiovascular risk markers. All participants will be asked to weigh themselves daily on a study-provided Bluetooth-enabled scale. Participants randomized to the Keyto arm will also be asked to measure their breath acetone levels, a measure of ketosis, with the Keyto device 3 times per day. Results Recruitment started in December 2019. Rolling recruitment is expected to be completed by July 2020. Data collection and analysis of the primary intervention phase is expected to be completed in October 2020. The 24- and 48-week follow-ups are expected to be completed in January 2021 and July 2021, respectively. Conclusions This trial will provide high-quality evidence regarding the efficacy of the Keyto weight loss program in individuals who are overweight and obese in a free-living condition. This study also fills a gap by examining the impact of a ketogenic diet emphasizing plant- and fish-based fats on blood lipid profile and cardiovascular disease risk. Trial Registration ClinicalTrials.gov NCT04165707; https://clinicaltrials.gov/ct2/show/NCT04165707. International Registered Report Identifier (IRRID) DERR1-10.2196/19053

scholarly journals Severe Metabolic Acidosis: A Case of Triple Hit with Ketogenic Diet, Vinegar, and Metformin in an Obese Patient

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Abdul Mughees Rana ◽  
Kannan Mansoor ◽  
Salman Assad ◽  
Mahmoud Abouzid ◽  
Iheanyichukwu Ogu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Acetic Acid ◽  
Adverse Effects ◽  
Ketogenic Diet ◽  
Herbal Supplements ◽  
Dietary Practices ◽  
Over The Counter ◽  
Mainstream Media ◽  
Ketogenic Diets ◽  
Increased Risk

Obesity is an epidemic with high burden of disease. It is directly proportional to increased risk of morbidity and mortality. Ketogenic diet and herbal supplements have recently gained popularity amongst patients struggling with weight loss. There are limited data available for most of these supplements contrary to the claims laid by the mainstream media. Due to lack of awareness, this patient population is at high risk of adverse effects. We present a case of severe acidosis secondary to ketogenic diet and acetic acid (vinegar) ingestion. The use of dietary acetic acid is usually well tolerated; however, in this case, the large quantities and presence of acute renal injury and metformin use may have worsened the acidosis. Severe ketosis in setting of ketogenic diets is a serious complication, which is infrequently reported in literature. Many of these diets and supplements may seem harmless, but as our case illustrates, when combined with other risk factors, patients can face serious adverse effects and even require hospitalization. It is imperative that such dietary practices are physician supervised to avoid complications. With the recent surge of over-the-counter weight loss supplements and ketogenic diets, physicians also need to engage in dietary discussion with patients when attempting to lose weight.

scholarly journals Ketogenic Diet Therapies for Seizures and Status Epilepticus

2020 ◽  
Vol 40 (06) ◽  
pp. 719-729
Author(s):  
Tanya J. W. McDonald ◽  
Mackenzie C. Cervenka
Keyword(s):  
Status Epilepticus ◽  
Ketogenic Diet ◽  
Care Setting ◽  
Drug Resistant ◽  
Anesthetic Agents ◽  
Ketogenic Diets ◽  
Potential Efficacy ◽  
Low Carbohydrate ◽  
History Of ◽  
Drug Resistant Epilepsy

AbstractKetogenic diet therapies are high-fat, low-carbohydrate diets designed to mimic a fasting state. Although initially developed nearly one century ago for seizure management, most clinical trials for the management of drug-resistant epilepsy in children as well as adults have been conducted over the last 3 decades. Moreover, ketogenic diets offer promising new adjunctive strategies in the critical care setting for the resolution of acute status epilepticus when traditional antiseizure drugs and anesthetic agents fail. Here, we review the history of ketogenic diet development, the clinical evidence supporting its use for the treatment of drug-resistant epilepsy in children and adults, and the early evidence supporting ketogenic diet feasibility, safety, and potential efficacy in the management of status epilepticus.

scholarly journals Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic

2021 ◽  
Author(s):  
Marie Mclaughlin ◽  
Geraint Florida-James ◽  
Mark Ross
Keyword(s):  
Breast Cancer ◽  
Cancer Chemotherapy ◽  
Potential Role ◽  
Vascular Toxicity ◽  
Exercise Interventions ◽  
Breast Cancer Chemotherapy ◽  
Mediating Mechanisms ◽  
The Impact ◽  
Health Function

Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its central importance within the cardiovascular system and resultant detrimental effects of damage and dysfunction. This review highlights the impact of chemotherapy for breast cancer on the vascular endothelium. We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. There are sharp consequences of these detrimental effects as they can lead to cardiovascular disease. However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. The potential role of exercise in protecting against vascular toxicity is explained, highlighting the recent in-human and animal model exercise interventions. Lastly, the mediating mechanisms of exercise protection of endothelial health is discussed, focusing on the importance of exercise for endothelial health, function, repair, inflammation and hyperlipidaemia, angiogenesis, and vascular remodelling. These are all important counteracting measures against chemotherapy-induced toxicity and are discussed in detail.

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