Physical Activity and Lung Cancer: A Case-Control Study in Brazil

2016 ◽  
Vol 13 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Maria Laura Resem Brizio ◽  
Pedro C. Hallal ◽  
I-Min Lee ◽  
Marlos Rodrigues Domingues
Keyword(s):  
Physical Activity ◽  
Lung Cancer ◽  
Case Control Study ◽  
Leisure Time Physical Activity ◽  
Cancer Control ◽  
Case Control ◽  
Control Subjects ◽  
History Of ◽  
And Control ◽  
Control Study

Background:The aim of this study was to investigate the association between lifetime physical activity and risk of lung cancer.Methods:A case-control study was conducted in southern Brazil. Case subjects were recruited from oncology services of 4 hospitals. Control subjects were selected from the same hospitals, but from different services (traumatology and emergency). Both case subjects (n = 81) and control subjects (n = 168) were interviewed using a questionnaire about sociodemographic characteristics, anthropometric information and family history of cancer. Control subjects were matched to case subjects according to sex and age (± 5 years). Detailed information on smoking was collected. Physical activity was measured using the Lifetime Physical Activity Questionnaire.Results:Of the case subjects, 89% were either current or former smokers; among control subjects, this value was 57%. Participants in the second, third, and fourth quartiles of all-domains physical activity had odds ratios of 0.54 (95% CI, 0.21–1.40), 0.25 (95% CI, 0.08–0.72), and 0.24 (95% CI, 0.07–0.83) for lung cancer, compared with the lowest quartile, after adjusting for confounding. In the fully adjusted models, leisure-time physical activity was not associated with lung cancer risk.Conclusion:Lifetime all-domains physical activity may reduce the risk of lung cancer.

Carotid ultrasound findings in rheumatoid arthritis and control subjects: A case-control study

2018 ◽  
Vol 22 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Martin I. Wah-Suarez ◽  
Dionicio A. Galarza-Delgado ◽  
Jose R. Azpiri-Lopez ◽  
Iris J. Colunga-Pedraza ◽  
Estefania E. Abundis-Marquez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Case Control ◽  
Carotid Ultrasound ◽  
Control Subjects ◽  
Ultrasound Findings ◽  
And Control ◽  
Control Study

scholarly journals Functional Status and Body Mass Index in Postmenopausal Women with Fibromyalgia: A Case–control Study

2019 ◽  
Vol 16 (22) ◽  
pp. 4540
Author(s):  
Laura Cerón Lorente ◽  
María Carmen García Ríos ◽  
Santiago Navarro Ledesma ◽  
Rosa María Tapia Haro ◽  
Antonio Casas Barragán ◽  
...  
Keyword(s):  
Physical Activity ◽  
Functional Status ◽  
Functional Capacity ◽  
Physical Disability ◽  
Leisure Time ◽  
Case Control Study ◽  
Leisure Time Physical Activity ◽  
Case Control ◽  
Functional Mobility ◽  
Control Study

Reduced functional capacity is a common characteristic of fibromyalgia (FMS). We aimed to investigate the relationship between functional status and body mass index (BMI) in a population with and without FMS. A pilot case–control study was performed in 34 women with FMS and 22 healthy controls which were classified according to their BMI. The main outcome measures were: Balance (MiniBestest, One Leg Stance Test), functional mobility (Timed up and Go), physical disability (Health Assessment Questionnaire Disability Index), spinal range of motion (Spinal Mouse), level of physical activity at work (Leisure Time Physical Activity Instrument), and home and leisure time (Physical Activity at Home and Work). Statistical differences were observed between overweight/obese healthy controls and women with FMS for several indicators of functional capacity. FMS patients reported worse dynamic (p = 0.001) and static balance (right: p = 0.002, left: p = 0.001), poorer functional mobility (p = 0.008), and higher levels of physical disability (p = 0.001). Functional status is altered in FMS women compared to the healthy control group, independently of nutritional status; therefore, BMI is unlikely to play a main role in functional capacity indicators in postmenopausal FMS women. Only dynamic balance seems to reduce the obesity status in this population.

Leisure time physical activity and mortality in hong kong: case-control study of all adult deaths in 1998

2004 ◽  
Vol 14 (6) ◽  
pp. 391-398 ◽  
Author(s):  
Tai-Hing Lam ◽  
Sai-Yin Ho ◽  
Anthony J Hedley ◽  
Kwok-Hang Mak ◽  
Gabriel M Leung
Keyword(s):  
Physical Activity ◽  
Hong Kong ◽  
Leisure Time ◽  
Case Control Study ◽  
Leisure Time Physical Activity ◽  
Case Control ◽  
Control Study

scholarly journals Combined and interaction effect of Chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in southeast China

2020 ◽  
Author(s):  
Xin Xu ◽  
Zhiqiang Liu ◽  
Weimin Xiong ◽  
Minglian Qiu ◽  
Shuling Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Environmental Factors ◽  
Passive Smoking ◽  
Chlamydia Pneumoniae ◽  
Case Control Study ◽  
Case Control ◽  
Combined Effects ◽  
History Of ◽  
Control Study ◽  
History Of Cancer

Abstract Objective: This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Chlamydia pneumoniae infection and smoking or other environmental factors.Methods: The study was comprised of 449 lung cancer patients and 512 age- and gender-matched healthy controls. All participants provided a 5-ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer.Results: Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34 - 3.00) of developing lung cancer. Smokers with Cpn IgG+ or IgA+ were associated with a significantly increased risk of lung cancer, the adjusted OR was 1.79 (95% CI: 1.10-2.91) or 2.27(95% CI:1.38-3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also increased the risk of lung cancer, the adjusted OR was 1.82 (95% CI: 1.20-2.77) or 1.87(95% CI:1.22-2.87), respectively. The similar results were also observed among alcohol drinking people. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ and smoking, passive smoking, family history of cancer were found on lung cancer.Conclusion: The Cpn infection was potentially associated with primary lung cancer in the Chinese Han population and had combined effects with smoking, passive smoking, and the family history of cancer.

scholarly journals Combined and interaction effect of Chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in southeast China

2020 ◽  
Author(s):  
Xin Xu ◽  
Zhiqiang Liu ◽  
Weimin Xiong ◽  
Minglian Qiu ◽  
Shuling Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Passive Smoking ◽  
Chlamydia Pneumoniae ◽  
Case Control Study ◽  
Case Control ◽  
Combined Effects ◽  
Increased Risk ◽  
History Of ◽  
Control Study ◽  
History Of Cancer

Abstract Background: This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmental factors.Methods: The study comprised 449 lung cancer patients and 512 age- and gender-matched healthy controls. All participants provided a 5 ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer.Results: Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34–3.00) of developing lung cancer. Cpn IgG+ or IgA+ was associated with a significantly increased risk of lung cancer among smokers; the adjusted odds ratio (OR) was 1.79 (95% CI: 1.10–2.91) and 2.27 (95% CI: 1.38–3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also showed an increased risk of lung cancer; the adjusted OR was 1.82 (95% CI: 1.20–2.77) or 1.87 (95% CI: 1.22–2.87), respectively. Similar results were also observed among alcohol drinkers. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ with smoking, passive smoking, and family history of cancer on lung cancer were determined.Conclusion: Cpn infection is potentially associated with primary lung cancer in the Chinese Han population and has combined effects with smoking, passive smoking, and family history of cancer.

scholarly journals Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xin Xu ◽  
Zhiqiang Liu ◽  
Weimin Xiong ◽  
Minglian Qiu ◽  
Shuling Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Environmental Factors ◽  
Passive Smoking ◽  
Chlamydia Pneumoniae ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
History Of ◽  
Control Study ◽  
History Of Cancer

Abstract Background This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmental factors. Methods The study comprised 449 lung cancer patients and 512 age- and sex-matched healthy controls. All participants provided a 5 ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer. Results Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34–3.00) of developing lung cancer. Cpn IgG+ or IgA+ was associated with a significantly increased risk of lung cancer among smokers; the adjusted odds ratio (OR) was 1.79 (95% CI: 1.10–2.91) and 2.27 (95% CI: 1.38–3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also showed an increased risk of lung cancer; the adjusted OR was 1.82 (95% CI: 1.20–2.77) or 1.87 (95% CI: 1.22–2.87), respectively. Similar results were also observed among alcohol drinkers. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ with smoking, passive smoking, and family history of cancer on lung cancer were determined. Conclusion Cpn infection is potentially associated with primary lung cancer in the Chinese Han population and has combined effects with smoking, passive smoking, and family history of cancer.

scholarly journals Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

2019 ◽  
Vol 2019 ◽  
pp. 1-23
Author(s):  
Qi Shen ◽  
Wen-xiang Wang ◽  
Qiu-ping Xu ◽  
Wen-min Xiong ◽  
Zhi-qiang Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Primary Lung Cancer ◽  
Case Control ◽  
Single Nucleotide ◽  
History Of ◽  
Control Study ◽  
History Of Cancer ◽  
Lung Cancer Susceptibility

The purpose of the current study is to explore the contribution of single-nucleotide polymorphisms (SNPs) of REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 to the risk of lung cancer. A questionnaire survey was used to obtain basic information of the included subjects. A case control study was performed in 1121 patients and 1121 controls. All subjects were subjected to blood sampling for genomic DNA extraction and genotyping of the cancer stem cell-associated gene SNPs, including REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 by real-time PCR. The association with the risk of primary lung cancer and interaction with environmental factors were assessed using unconditional logistic regression for the odds ratios and corresponding 95% confidence intervals. The genotype frequency distribution of OCT4 rs13409 loci was statistically significant, but there was no significant difference in the rest of the loci between lung cancer patients and healthy controls. The OCT4 gene was also related with lung cancer susceptibility in the genetic model after adjusting for lung cancer-related factors. Despite the presence of the dominant or recessive model, the four loci polymorphisms were associated with pollution near the place of residence, house type, worse ventilation situation, smoking, passive smoking, cooking oil fumes (COF), and family history of cancer, which increased the risk of lung cancer. Nonmarried status, 18.5≤BMI, COF, smoking, passive smoking, family history of cancer, and history of lung disease were independent risk factors of lung cancer susceptibility. Additionally, college degree or above, no pollution near the place of residence, protective genotype 1 or 2, and well ventilation can reduce the occurrence of lung cancer. There is an interaction between the four loci and environmental factors, and OCT4 rs13409 is a risk factor of primary lung cancer.

Sign in / Sign up

Export Citation Format

Share Document