Combined and interaction effect of Chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in southeast China

Abstract Objective: This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Chlamydia pneumoniae infection and smoking or other environmental factors.Methods: The study was comprised of 449 lung cancer patients and 512 age- and gender-matched healthy controls. All participants provided a 5-ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer.Results: Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34 - 3.00) of developing lung cancer. Smokers with Cpn IgG+ or IgA+ were associated with a significantly increased risk of lung cancer, the adjusted OR was 1.79 (95% CI: 1.10-2.91) or 2.27(95% CI:1.38-3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also increased the risk of lung cancer, the adjusted OR was 1.82 (95% CI: 1.20-2.77) or 1.87(95% CI:1.22-2.87), respectively. The similar results were also observed among alcohol drinking people. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ and smoking, passive smoking, family history of cancer were found on lung cancer.Conclusion: The Cpn infection was potentially associated with primary lung cancer in the Chinese Han population and had combined effects with smoking, passive smoking, and the family history of cancer.

Download Full-text

Combined and interaction effect of Chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in southeast China

10.21203/rs.2.23930/v1 ◽

2020 ◽

Author(s):

Xin Xu ◽

Zhiqiang Liu ◽

Weimin Xiong ◽

Minglian Qiu ◽

Shuling Kang ◽

...

Keyword(s):

Lung Cancer ◽

Environmental Factors ◽

Passive Smoking ◽

Chlamydia Pneumoniae ◽

Case Control Study ◽

Case Control ◽

Combined Effects ◽

History Of ◽

Control Study ◽

History Of Cancer

Abstract Background: This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Chlamydia pneumoniae infection and smoking or other environmental factors. Methods: The study was comprised of 449 lung cancer patients and 512 age- and gender-matched healthy controls. All participants provided a 5-ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer. Results: Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34 - 3.00) of developing lung cancer. Smokers with Cpn IgG+ or IgA+ were associated with a significantly increased risk of lung cancer, the adjusted OR was 1.79 (95% CI: 1.10-2.91) or 2.27(95% CI:1.38-3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also increased the risk of lung cancer, the adjusted OR was 1.82 (95% CI: 1.20-2.77) or 1.87(95% CI:1.22-2.87), respectively. The similar results were also observed among alcohol drinking people. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ and smoking, passive smoking, family history of cancer were found on lung cancer. Conclusion: The Cpn infection was potentially associated with primary lung cancer in the Chinese Han population and had combined effects with smoking, passive smoking, and the family history of cancer. Keywords: Chlamydia pneumoniae infection, case-control study, environmental factors, lung cancer

Download Full-text

Combined and interaction effect of Chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in southeast China

10.21203/rs.2.23930/v2 ◽

2020 ◽

Author(s):

Xin Xu ◽

Zhiqiang Liu ◽

Weimin Xiong ◽

Minglian Qiu ◽

Shuling Kang ◽

...

Keyword(s):

Lung Cancer ◽

Passive Smoking ◽

Chlamydia Pneumoniae ◽

Case Control Study ◽

Case Control ◽

Combined Effects ◽

Increased Risk ◽

History Of ◽

Control Study ◽

History Of Cancer

Abstract Background: This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmental factors.Methods: The study comprised 449 lung cancer patients and 512 age- and gender-matched healthy controls. All participants provided a 5 ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer.Results: Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34–3.00) of developing lung cancer. Cpn IgG+ or IgA+ was associated with a significantly increased risk of lung cancer among smokers; the adjusted odds ratio (OR) was 1.79 (95% CI: 1.10–2.91) and 2.27 (95% CI: 1.38–3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also showed an increased risk of lung cancer; the adjusted OR was 1.82 (95% CI: 1.20–2.77) or 1.87 (95% CI: 1.22–2.87), respectively. Similar results were also observed among alcohol drinkers. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ with smoking, passive smoking, and family history of cancer on lung cancer were determined.Conclusion: Cpn infection is potentially associated with primary lung cancer in the Chinese Han population and has combined effects with smoking, passive smoking, and family history of cancer.

Download Full-text

Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

BMC Cancer ◽

10.1186/s12885-020-07418-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Xin Xu ◽

Zhiqiang Liu ◽

Weimin Xiong ◽

Minglian Qiu ◽

Shuling Kang ◽

...

Keyword(s):

Lung Cancer ◽

Environmental Factors ◽

Passive Smoking ◽

Chlamydia Pneumoniae ◽

Case Control Study ◽

Case Control ◽

Increased Risk ◽

History Of ◽

Control Study ◽

History Of Cancer

Abstract Background This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmental factors. Methods The study comprised 449 lung cancer patients and 512 age- and sex-matched healthy controls. All participants provided a 5 ml fasting peripheral venous blood sample for testing Cpn-specific IgG and IgA by using micro-immunofluorescence. Besides analyzing the associations between Cpn and lung cancer, combined effect analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of Cpn and environmental factors on lung cancer. Results Compared to those with no evidence of serum Cpn IgA or Cpn IgG, those with both Cpn IgG+ and IgA+ had 2.00 times the risk (95% CI: 1.34–3.00) of developing lung cancer. Cpn IgG+ or IgA+ was associated with a significantly increased risk of lung cancer among smokers; the adjusted odds ratio (OR) was 1.79 (95% CI: 1.10–2.91) and 2.27 (95% CI: 1.38–3.72), respectively. Those exposed to passive smoking with Cpn IgG+ or IgA+ also showed an increased risk of lung cancer; the adjusted OR was 1.82 (95% CI: 1.20–2.77) or 1.87 (95% CI: 1.22–2.87), respectively. Similar results were also observed among alcohol drinkers. Multiplicative and additive interactions were not observed between Cpn infection and environmental factors. The combined effects of Cpn IgG+ or IgA+ with smoking, passive smoking, and family history of cancer on lung cancer were determined. Conclusion Cpn infection is potentially associated with primary lung cancer in the Chinese Han population and has combined effects with smoking, passive smoking, and family history of cancer.

Download Full-text

Relation of Family History of Cancer and Environmental Factors to the Risk of Colorectal Cancer: A Case-control Study

Japanese Journal of Clinical Oncology ◽

10.1093/oxfordjournals.jjco.a039777 ◽

1995 ◽

Cited By ~ 1

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Environmental Factors ◽

Case Control Study ◽

Case Control ◽

Family History Of Cancer ◽

History Of ◽

Control Study ◽

History Of Cancer

Download Full-text

Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

Disease Markers ◽

10.1155/2019/4150263 ◽

2019 ◽

Vol 2019 ◽

pp. 1-23

Author(s):

Qi Shen ◽

Wen-xiang Wang ◽

Qiu-ping Xu ◽

Wen-min Xiong ◽

Zhi-qiang Liu ◽

...

Keyword(s):

Lung Cancer ◽

Case Control Study ◽

Cancer Susceptibility ◽

Primary Lung Cancer ◽

Case Control ◽

Single Nucleotide ◽

History Of ◽

Control Study ◽

History Of Cancer ◽

Lung Cancer Susceptibility

The purpose of the current study is to explore the contribution of single-nucleotide polymorphisms (SNPs) of REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 to the risk of lung cancer. A questionnaire survey was used to obtain basic information of the included subjects. A case control study was performed in 1121 patients and 1121 controls. All subjects were subjected to blood sampling for genomic DNA extraction and genotyping of the cancer stem cell-associated gene SNPs, including REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 by real-time PCR. The association with the risk of primary lung cancer and interaction with environmental factors were assessed using unconditional logistic regression for the odds ratios and corresponding 95% confidence intervals. The genotype frequency distribution of OCT4 rs13409 loci was statistically significant, but there was no significant difference in the rest of the loci between lung cancer patients and healthy controls. The OCT4 gene was also related with lung cancer susceptibility in the genetic model after adjusting for lung cancer-related factors. Despite the presence of the dominant or recessive model, the four loci polymorphisms were associated with pollution near the place of residence, house type, worse ventilation situation, smoking, passive smoking, cooking oil fumes (COF), and family history of cancer, which increased the risk of lung cancer. Nonmarried status, 18.5≤BMI, COF, smoking, passive smoking, family history of cancer, and history of lung disease were independent risk factors of lung cancer susceptibility. Additionally, college degree or above, no pollution near the place of residence, protective genotype 1 or 2, and well ventilation can reduce the occurrence of lung cancer. There is an interaction between the four loci and environmental factors, and OCT4 rs13409 is a risk factor of primary lung cancer.

Download Full-text

Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case–control study

Journal of Human Genetics ◽

10.1038/jhg.2013.78 ◽

2013 ◽

Vol 58 (10) ◽

pp. 679-685 ◽

Cited By ~ 6

Author(s):

Fei He ◽

Shen-Chih Chang ◽

Gina Maria Wallar ◽

Zuo-Feng Zhang ◽

Lin Cai

Keyword(s):

Lung Cancer ◽

Gene Polymorphisms ◽

Chinese Population ◽

Case Control Study ◽

Case Control ◽

Small Cell ◽

Small Cell Lung ◽

History Of ◽

Control Study ◽

History Of Cancer

Download Full-text

A family history of cancer and lung cancer risk in never-smokers: A clinic-based case–control study

Lung Cancer ◽

10.1016/j.lungcan.2015.05.017 ◽

2015 ◽

Vol 89 (2) ◽

pp. 94-98 ◽

Cited By ~ 13

Author(s):

Huan Lin ◽

Yi-Sheng Huang ◽

Hong-hong Yan ◽

Xue-Ning Yang ◽

Wen-Zhao Zhong ◽

...

Keyword(s):

Lung Cancer ◽

Family History ◽

Cancer Risk ◽

Case Control Study ◽

Lung Cancer Risk ◽

Case Control ◽

History Of ◽

Never Smokers ◽

Control Study ◽

History Of Cancer

Download Full-text

Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

European Journal of Medical Research ◽

10.1186/s40001-021-00561-3 ◽

2021 ◽

Vol 26 (1) ◽

Author(s):

Arisara Poosari ◽

Thitima Nutravong ◽

Prakasit Sa-ngiamwibool ◽

Wises Namwat ◽

Supaporn Chatrchaiwiwatana ◽

...

Keyword(s):

Risk Factors ◽

Esophageal Cancer ◽

Oral Hygiene ◽

Case Control Study ◽

Significant Risk ◽

Case Control ◽

Poor Oral Hygiene ◽

History Of ◽

Control Study ◽

History Of Cancer

Abstract Background Previous studies have shown the association between Campylobacter species infection and that environmental factors, poor oral hygiene in particular, are linked to an increased risk of esophageal cancer (EC). However, no study has reported on these factors in Thailand. Thus, this study’s objective was to evaluate the impact of the relationship between Campylobacter infection and environmental factors on EC incidence in the population of Thailand. Methods Data from a case–control study were collected from 105 newly diagnosed EC cases and 105 controls recruited from 2007 to 2017. Infection with Campylobacter spp. was detected in the formalin-fixed paraffin-embedded (FFPE) tissue of EC taken from gastroesophageal biopsy specimens obtained from the participants, and evaluated using TaqMan® real-time PCR. Multivariable logistic regression was performed to calculate the odds ratios (ORs) and perform data analysis. Results Smoking, alcohol use, a family history of cancer, history of gastroesophageal reflux disease, poor oral hygiene and Campylobacter spp. infection were shown to be significant risk factors for EC (p < 0.05). The combination of poor oral hygiene and infection with Campylobacter spp. constituted significant risk for EC (p < 0.001). In addition, the risk of EC in subjects co-infected with C. rectus and C. concisus that practiced poor oral hygiene was even higher and was significant (ORadj = 4.7; 95% CI 2.41–9.98; p = 0.003). Conclusions In Thailand, the major risk factors for EC are smoking status, alcohol drinking, family history of cancer, GERD, poor oral hygiene and Campylobacter spp. infection. This study found Campylobacter spp. prevalence to be associated with EC and appears to be enhanced by poor oral hygiene, suggesting that a combination of poor oral hygiene and Campylobacter species infection may together act as an important etiological risk factor for EC.

Download Full-text