scholarly journals Nicotine Pharmacokinetics in Rats Is Altered as a Function of Age, Impacting the Interpretation of Animal Model Data

2014 ◽  
Vol 42 (9) ◽  
pp. 1447-1455 ◽  
Author(s):  
Evelyn L. Craig ◽  
Bin Zhao ◽  
Jason Z. Cui ◽  
Maria Novalen ◽  
Sharon Miksys ◽  
...  
Keyword(s):  
Animal Model ◽  
Model Data ◽  
Nicotine Pharmacokinetics ◽  
Pharmacokinetics In Rats

Estimates of heritabilities of Canadian Holstein conformation traits by threshold model

1991 ◽  
Vol 71 (3) ◽  
pp. 629-632 ◽  
Author(s):  
J. Jamrozik ◽  
L. R. Schaeffer ◽  
E. B. Burnside ◽  
B. P. Sullivan
Keyword(s):  
Animal Model ◽  
Em Algorithm ◽  
Variance Components ◽  
Fixed Effects ◽  
Threshold Model ◽  
Model Data ◽  
Stage Of Lactation ◽  
Continuous Scale ◽  
Type Traits ◽  
Holstein Population

Sire variances for 30 conformation traits on Canadian Holsteins were estimated on the underlying continuous scale using a single trait threshold linear model. Data were linearized first classifications on 66 617 cows by 3305 sires, classified since February 1988. The model included a random sire effect and fixed effects of herd-round of classification-classifier, age at classification and stage of lactation at classification. Sires were assumed unrelated in this study. Variance components for sires were estimated by REML EM algorithm. Estimates of heritabilities were generally larger than those currently used in genetic evaluation for type traits in Canadian Holstein population. The new heritabilities are recommended for use in a traditional linear animal model procedure. Key words: Variance components, threshold model, type traits

Pathology of human intracranial aneurysms after GDC-embolization in correlation with animal model data

1997 ◽  
Vol 99 ◽  
pp. S97
Author(s):  
C. Gaebel ◽  
J. Reul ◽  
E. Reusche ◽  
U. Missler ◽  
T. Mayer ◽  
...  
Keyword(s):  
Animal Model ◽  
Intracranial Aneurysms ◽  
Model Data

Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats

2007 ◽  
Vol 194 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Mark G. LeSage ◽  
Daniel E. Keyler ◽  
Danielle Burroughs ◽  
Paul R. Pentel
Keyword(s):  
Self Administration ◽  
Nicotine Pharmacokinetics ◽  
Pharmacokinetics In Rats

scholarly journals Evaluation of Once-Weekly Therapy for Tuberculosis Using Isoniazid plus Rifamycins in the Mouse Aerosol Infection Model

1998 ◽  
Vol 42 (11) ◽  
pp. 3047-3048 ◽  
Author(s):  
Jason V. Brooks ◽  
Ian M. Orme
Keyword(s):  
Animal Model ◽  
Mycobacterium Tuberculosis ◽  
Low Dose ◽  
Infection Model ◽  
Model Data ◽  
Highly Effective ◽  
Clinical Conditions ◽  
Aerosol Infection ◽  
Weekly Therapy

ABSTRACT Once-weekly therapy with combinations of isoniazid plus a rifamycin was tested in the mouse low-dose aerosol infection model against two strains of Mycobacterium tuberculosis. Combinations of isoniazid and rifalizil and isoniazid and rifapentine were both highly effective. These animal model data thus support the evaluation of these regimens under clinical conditions.

Response: Optimizing the niche conditions for maximal stem cell engraftment: human and animal model data

Blood ◽  
2009 ◽  
Vol 114 (26) ◽  
pp. 5406-5407
Author(s):  
Massimo Dominici ◽  
Edwin M. Horwitz
Keyword(s):  
Animal Model ◽  
Stem Cell ◽  
Model Data ◽  
Cell Engraftment

scholarly journals Comparison of Virulence ofLegionella longbeachae Strains in Guinea Pigs and U937 Macrophage-Like Cells

2001 ◽  
Vol 69 (9) ◽  
pp. 5335-5344 ◽  
Author(s):  
Robyn M. Doyle ◽  
Nicholas P. Cianciotto ◽  
Shaila Banvi ◽  
Paul A. Manning ◽  
Michael W. Heuzenroeder
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
U937 Cells ◽  
Model Data ◽  
Phagocytic Cells ◽  
Model Studies ◽  
Severity Of Disease ◽  
Cellular Debris ◽  
Guinea Pig Model ◽  
U937 Macrophage

ABSTRACT A guinea pig model of experimental legionellosis was established for assessment of virulence of isolates of Legionella longbeachae. The results showed that there were distinct virulence groupings of L. longbeachae serogroup 1 strains based on the severity of disease produced in this model. Statistical analysis of the animal model data suggests that Australian isolates of L. longbeachae may be inherently more virulent than non-Australian strains. Infection studies performed with U937 cells were consistent with the animal model studies and showed that isolates of this species were capable of multiplying within these phagocytic cells. Electron microscopy studies of infected lung tissue were also undertaken to determine the intracellular nature of L. longbeachae serogroup 1 infection. The data showed that phagosomes containing virulent L. longbeachae serogroup 1 appeared bloated, contained cellular debris and had an apparent rim of ribosomes while those containing avirulent L. longbeachae serogroup 1 were compact, clear and smooth.

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