Dominance of Amyloid Precursor Protein Sequence over Host Cell Secretases in Determining β-Amyloid Profiles Studies of Interspecies Variation and Drug Action by Internally Standardized Immunoprecipitation/Mass Spectrometry

2007 ◽  
Vol 320 (3) ◽  
pp. 1144-1152 ◽  
Author(s):  
Ping Du ◽  
Kathleen M. Wood ◽  
Michele H. Rosner ◽  
David Cunningham ◽  
Barbara Tate ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amyloid Precursor Protein ◽  
Host Cell ◽  
Protein Sequence ◽  
Drug Action ◽  
Precursor Protein ◽  
Interspecies Variation ◽  
Β Amyloid

An on-flow assay for screening of β-secretase ligands by immobilised capillary reactor-mass spectrometry

2017 ◽  
Vol 9 (14) ◽  
pp. 2189-2196 ◽  
Author(s):  
Adriana Ferreira Lopes Vilela ◽  
Carmen Lúcia Cardoso
Keyword(s):  
Mass Spectrometry ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Mass Spectrometer ◽  
Precursor Protein ◽  
Enzyme Reactor ◽  
Β Amyloid

The enzyme β-secretase1 (BACE1) initiates the cleavage of the Ab amyloid precursor protein (APP), to generate and aggregate β-amyloid (Ab) peptides, which are implicated in the pathogenesis of Alzheimer's disease (AD). Herein, a BACE1 immobilised capillary enzyme reactor (ICER) attached to a mass spectrometer for the on-flow screening of ligands was prepared.

scholarly journals Expression of β-Amyloid Precursor Protein-CD3γ Chimeras to Demonstrate the Selective Generation of Amyloid β1–40and Amyloid β1–42Peptides within Secretory and Endocytic Compartments

1999 ◽  
Vol 274 (45) ◽  
pp. 32295-32300 ◽  
Author(s):  
Salvador Soriano ◽  
Abraham S. C. Chyung ◽  
Xiaohua Chen ◽  
Gorazd B. Stokin ◽  
Virginia M.-Y. Lee ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Selective Generation ◽  
Β Amyloid ◽  
Endocytic Compartments

scholarly journals β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

Cell ◽  
1995 ◽  
Vol 81 (4) ◽  
pp. 525-531 ◽  
Author(s):  
Hui Zheng ◽  
Minghao Jiang ◽  
Myrna E. Trumbauer ◽  
Dalip J.S. Sirinathsinghji ◽  
Ruth Hopkins ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Reactive Gliosis ◽  
Β Amyloid ◽  
Deficient Mice
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