Novel Platform for Predicting Drug Effects in Patients with Acromegaly: Translational Exposure-Response Evaluation of Growth Hormone-Inhibitory Effect of Octreotide Following Growth Hormone-Releasing Hormone Stimulation

2021 ◽  
pp. JPET-AR-2021-000769
Author(s):  
Hiroyuki Iida ◽  
Tatsuya Komagata ◽  
Hirotaka Tanaka ◽  
Ryusuke Nagasawa ◽  
Takuya Nishio ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Drug Effects ◽  
Inhibitory Effect ◽  
Growth Hormone Releasing Hormone ◽  
Response Evaluation ◽  
Releasing Hormone ◽  
Hormone Stimulation ◽  
Exposure Response

Differential Secretion of Chicken Growth Hormone Variants After Growth Hormone-Releasing Hormone Stimulation In Vitro

Endocrine ◽  
2002 ◽  
Vol 17 (2) ◽  
pp. 91-102 ◽  
Author(s):  
Hilda Martínez-Coria ◽  
L Javier López-Rosales ◽  
Martha Carranza ◽  
Laura Berumen ◽  
Maricela Luna ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Stimulation

Inhibitory Effect of Amylin on Growth Hormone Responsiveness to Growth-Hormone-Releasing Hormone in the Rat

1995 ◽  
Vol 62 (3) ◽  
pp. 313-318 ◽  
Author(s):  
Carmela Netti ◽  
Valeria Sibilia ◽  
Francesca Pagani ◽  
Norma Lattuada ◽  
Mariella Coluzzi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Inhibitory Effect ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Responsiveness

GALANIN ABOLISHES THE INHIBITORY EFFECT OF CHOLINERGIC BLOCKADE ON GROWTH HORMONE-RELEASING HORMONE-INDUCED SECRETION OF GROWTH HORMONE IN MAN

1988 ◽  
Vol 116 (3) ◽  
pp. R1-R2 ◽  
Author(s):  
V.K.K. Chatterjee ◽  
J.A. Ball ◽  
C. Proby ◽  
J.M. Burrin ◽  
S.R. Bloom
Keyword(s):  
Growth Hormone ◽  
Inhibitory Effect ◽  
Normal Male ◽  
Growth Hormone Releasing Hormone ◽  
Maximal Dose ◽  
Muscarinic Antagonist ◽  
Releasing Hormone ◽  
Cholinergic Pathways ◽  
Cholinergic Blockade ◽  
Male Volunteers

ABSTRACT In five healthy normal male volunteers, pretreatment with the cholinergic muscarinic antagonist pirenzepine (30 mg i.v.) almost abolished the growth hormone (GH) response to a maximal dose (120 μg i.v.) of growth hormone-releasing hormone (GHRH) (GH response at 40 min 5.6 ± 1.3 mU/l with GHRH and pirenzepine vs 40.8 ± 5.3 mU/l with GHRH alone, P <0.02). Concomitant i.v. infusion of galanin (40 pmol/kg/min) with pirenzepine not only restored but significantly potentiated the GH response to GHRH (GH at 40 min 72.2 ± 10.5 mU/l, P <0.001 vs GHRH and pirenzepine, P <0.02 vs GHRH alone). Previous studies have proposed that cholinergic pathways control GH release via samatostatin and this study suggests that galanin may act by modulating hypothalamic somatostatinergic tone either directly or, possibly, by facilitating cholinergic neurotransmission.

The growth hormone response to growth hormone-releasing hormone stimulation in infantile protein-calorie malnutrition

1990 ◽  
Vol 10 (10) ◽  
pp. 1073-1080
Author(s):  
Santiago Muzzo ◽  
Raquel Burrows ◽  
Jorge Winterer ◽  
Isabel Young ◽  
Saul Malozowski ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Response ◽  
Growth Hormone Releasing Hormone ◽  
Hormone Response ◽  
Releasing Hormone ◽  
Hormone Stimulation ◽  
Protein Calorie Malnutrition
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