scholarly journals MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells

2009 ◽  
Vol 75 (6) ◽  
pp. 1374-1379 ◽  
Author(s):  
Yu-Zhuo Pan ◽  
Marilyn E. Morris ◽  
Ai-Ming Yu
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Resistance Protein ◽  
Human Cancer ◽  
Cancer Resistance ◽  
Human Cancer Cells ◽  
Resistance Protein

Transcriptional Upregulation of Breast Cancer Resistance Protein by 17β-Estradiol in ERα-Positive MCF-7 Breast Cancer Cells

Oncology ◽  
2006 ◽  
Vol 71 (5-6) ◽  
pp. 446-455 ◽  
Author(s):  
Yuhua Zhang ◽  
Gengyin Zhou ◽  
Huaiping Wang ◽  
Xiaofang Zhang ◽  
Fulan Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
17Β Estradiol ◽  
Resistance Protein ◽  
Mcf 7

scholarly journals Evaluation Of The Quercetin Semisynthetic Derivatives Interaction With Breast Cancer Resistance Protein

2020 ◽  
Author(s):  
A.E. Manukyan ◽  
A.A. Hovhannisyan
Keyword(s):  
Breast Cancer ◽  
Virtual Screening ◽  
Breast Cancer Resistance Protein ◽  
Human Cancer ◽  
Treatment Strategies ◽  
Multi Drug Resistance ◽  
List Type ◽  
Cancer Resistance ◽  
Quercetin Derivatives ◽  
Resistance Protein

AbstractBreast cancer resistance protein (BCRP, ABCG2) is one of the ATP binding cassette (ABC) transporter proteins which involved in multi-drug resistance of cancer therapy. BCRP is expressed in various types of human cancer and inhibiting can be a solution to overcome multidrug resistance. Significant effort has been devoted to develop treatment strategies to overcome BCRP-mediated resistance. In addition, BCRP is expressed also in many normal tissues and plays an important role in drug absorption, distribution, and elimination. In order to design an effective cancer treatment strategy, a lot of flavones and their derivatives are used as anticancer drug compounds. One of the most promising flavonols is quercetin and quercetin semisynthetic derivatives which can inhibit the expression of BCRP.HighlightsVirtual screening using multiple docking program for consensus predictions.Virtual screening of the quercetin derivatives as potential inhibitors of BCRP.Selected derivatives bind to the main amino acids of proteins.Selected derivatives meet the criteria necessary for their consideration as drugs.

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